6G18,6EML


Conserved Protein Domain Family
KH-I_PNO1_rpt2
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cd22392: KH-I_PNO1_rpt2 
second type I K homology (KH) RNA-binding domain found in partner of NOB1 (PNO1) and similar proteins
PNO1 is an RNA-binding protein that acts as a ribosome assembly factor and plays an important role in ribosome biogenesis. It positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. PNO1 contains two K-homology (KH) RNA-binding domains. The model corresponds to the second one.
Links
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Statistics
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PSSM-Id: 411820
Aligned: 56 rows
Threshold Bit Score: 152.354
Created: 18-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                              # ## ### ##### ###           #              #           ##
6G18_XX      154 RLDDLFLESFEITDVKP-LKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVKVHILGSFQNIKMARTAICNLILGN 232
NP_586381     85 KFSDVFLDRFEISEVKT-LRGLHIERAVGRIIGREGKTRDAIEEFSRSKIIVQGQTIHLLGTVENTRIARDAICRLIMGS 163 Encephalitozoon...
Q54K66       141 RLDDLYIDSFDVEDVKI-LKGDNLSRAIGRVAGKDGKTKFTIENVTKTRIVLADKRIHILGSYSNIRVAKDAICDLIIGS 219 Dictyostelium d...
EET00331     106 KMDNLYIDSFDITNVKLvLKGDNMSRAIGRIAGSGGKVKFTIENASKTRIVLADKTVHILGTVAGTRVARDAICDLILGL 185 Giardia intesti...
KYQ89131     146 RLDDLFIDSFDVEDVKI-LKGDNLSRAIGRVAGKDGKTKFTIENVTKTRIVLADKRVHILGSYSNIRVAKDAICDLVIGS 224 Tieghemostelium...
GAT94466      99 RMDDIFVDSFEIEDVKK-LHGDHLNRAIGRIAGKDGKTKFSIENTTHTRIVMQYKKIHIMGSYANIKIARDAIQDLILGA 177 Entamoeba histo...
XP_018648282  51 RIDGIYVNSFHIMDVKQtLKGDHMARAVGRICGAKGRIRMCIENATRTRIVVADETIHILGSNDRIAVARRAICDLILGA 130 Schistosoma man...
OUW47501     146 RVEDLYVDSFQVTDVKI-LKGDHLSRAIGRIAGKDGKVKFAIENATRTRIVLAEQNVHILGSHAHTRAAKDAVCSLILGS 224 Synechococcus s...
GAX24756      37 RLDDLYVESFQVTDVKL-LRGDHLSRAIGRIAGQDGKTRFAIENATRTRIVVADQRIHLLGSYANLRVARNAICDLILGA 115 Fistulifera sol...
PAA55132     137 RLDDLYIDTFTVADVKPsLKGDHVSRAIGRVAGKNGRTKFMIENATKTRIVVADHTIHILGAYDNVQAAKRTVCDLILGS 216 Macrostomum lig...

Feature 1        ## # #   #       
6G18_XX      233 PPSKVYGNIRAVASRSA 249
NP_586381    164 QPGSIFNRLRIINSRLK 180 Encephalitozoon cuniculi GB-M1
Q54K66       220 PPGKVYAKLRTVSSRIA 236 Dictyostelium discoideum
EET00331     186 SPNKVYQKLKMAASRFS 202 Giardia intestinalis ATCC 50581
KYQ89131     225 PPGKVYAKLKTIASRIQ 241 Tieghemostelium lacteum
GAT94466     178 PPGKVYNNLRTIASRMD 194 Entamoeba histolytica
XP_018648282 131 PPNKIFGKIRTHAARLD 147 Schistosoma mansoni
OUW47501     225 PPSKVYANLRAVSTRLG 241 Synechococcus sp. TMED187
GAX24756     116 PPGKVYNNMRNVAKRMS 132 Fistulifera solaris
PAA55132     217 PPSKVYGNMHARASKAA 233 Macrostomum lignano

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