6G18,6EML


Conserved Protein Domain Family
KH-I_PNO1_rpt1

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cd22391: KH-I_PNO1_rpt1 
first type I K homology (KH) RNA-binding domain found in partner of NOB1 (PNO1) and similar proteins
PNO1 is an RNA-binding protein that acts as a ribosome assembly factor and plays an important role in ribosome biogenesis. It positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. PNO1 contains two K-homology (KH) RNA-binding domains. The model corresponds to the first one. The KH1 domain is a divergent KH domain that lacks the RNA-binding GXXG motif.
Statistics
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PSSM-Id: 411819
Aligned: 60 rows
Threshold Bit Score: 118.786
Created: 12-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA bindingoligomer
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 ######                       #    #                                    
6G18_XX       73 EETRKIPVPANRYTPLKENWMKIFTPIVEHLGLQIRFNLKs--RNVEIRTCKEt-------kDVSALTKAADFVKAFILG 143
EET00331      25 FELRKVMVPYNRVSPIKREWNNICTPVVTELLLDIRYNISg--RCIEIRRNAKt-------iAPNALDRGQDFLRAITLG 95  Giardia intesti...
CUE65731      35 REARSVKIPTHRFPPLKRIWMEIYTPVVEQCKLEIRMNLKc--RCVELRTCEAt-------tDRALLQKAEDFVKAVVAG 105 Bodo saltans
PAA55132      54 VEKRSIVIPPNRRTPLRQQWPELCRILVEQLNLQCRCITRrpvWAVELRNSPLt-------kDDGHLQKGADLVDAFVKG 126 Macrostomum lig...
NP_586381      4 IQTRSVPIHPRKMKSMKDEWMKIYTPIVEMCKVQIRMNIKg--KSVDMRTCEHt-------eDPSYLERSAQYIEAINIG 74  Encephalitozoon...
CEO95264      51 IQTRAVVIPPHRFSPLKTHWMELYTPIVEHLRLQIRLNLKr--KVVQVRTSEHt-------eDSGAIQKAADFLRAFMLG 121 Plasmodiophora ...
GAT94466      19 EELREIHVPGQRFNYVKENWIGIYQPIVSQLKLNIRMNPSk--KLIQLKTNDKs--------QLDSLQKASDFINAIGKG 88  Entamoeba histo...
OHS95811      45 DDYRRVPIPPQRRAALRNNFPQIVQPIVQHLKLNIRYNTSl--NCVELKTSPEt-------tNPNAMTKATDFVQAFVNG 115 Tritrichomonas ...
XP_011776902  30 REMRTVKVPHHRFPALKKVWMDVYTPIVEQCKLEIRMNLRg--RSVELRTCPAtveaagnegSKALLQKAEDFVKAVVAG 107 Trypanosoma bru...
XP_001312076  17 PDYRRVAIPPNRRTYLKNNFPQITEPIIKYLKLDLRYNSRk--GCVELRTNALt-------sNPNAMTKAIDFLTAINAG 87  Trichomonas vag...
Feature 1                 
6G18_XX      144 FQVEDALAL 152
EET00331      96 FEVQDALAF 104 Giardia intestinalis ATCC 50581
CUE65731     106 FEVKDAMAL 114 Bodo saltans
PAA55132     127 FQIGDALAL 135 Macrostomum lignano
NP_586381     75 FPIEDAIAL 83  Encephalitozoon cuniculi GB-M1
CEO95264     122 FEIRDAIAL 130 Plasmodiophora brassicae
GAT94466      89 FEVKDAIAL 97  Entamoeba histolytica
OHS95811     116 FDVNDALAL 124 Tritrichomonas foetus
XP_011776902 108 FDVKDAVAL 116 Trypanosoma brucei gambiense DAL972
XP_001312076  88 FEIADALAL 96  Trichomonas vaginalis G3

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