Conserved Protein Domain Family
KH-I_DDX46_like

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cd22387: KH-I_DDX46_like 
type I K homology (KH) RNA-binding domain found in the family of DEAD box protein 46 (DDX46)
The DDX46 family includes DEAD box protein 46 (DDX46), fungal pre-mRNA-processing ATP-dependent RNA helicase PRP5, Arabidopsis thaliana DEAD-box ATP-dependent RNA helicase RH42 and similar proteins. DDX46, also called PRP5 homolog, is an ATP-dependent RNA helicase that plays an essential role in splicing, either prior to, or during splicing A complex formation. It inhibits antiviral innate responses by entrapping selected antiviral transcripts in the nucleus. It is also involved in the development of several tumors. PRP5 is an ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. It catalyzes an ATP-dependent conformational change of U2 snRNP. PRP5 interacts with the U2 snRNP and HSH155. RH42, also called DEAD-box RNA helicase RCF1, or REGULATOR OF CBF GENE EXPRESSION 1, is a helicase required for pre-mRNA splicing, cold-responsive gene regulation and cold tolerance. Members in this family contain a divergent KH domain that lacks the RNA-binding GXXG motif.
Statistics
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PSSM-Id: 411815
Aligned: 13 rows
Threshold Bit Score: 108.904
Created: 20-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7L014        928 SFKRYEEE-LEINDFPQTARWKVTSKEALQRISEysEAAITIRGTYFPPGKEpk----eGERKIYLAIESaneLAVQKAK 1002 human
A6ZLH6        749 GSIIFYAK-VYINDLPQIVRWEATKNTTLLFIKHetGCSITNKGKFYPEGKEpkn--enDEPKLYLLIEGqdeKDIQLSI 825  Saccharomyces...
XP_001582184  543 NDNLYIGE-ANINDYTKKARASVSSADNLNSVMDetGTMIIQKGVFCPPGVKpl----aGERRLYLRIEGttkFAVQAAL 617  Trichomonas v...
OHT02472      574 KDGTFITE-FVINDYSAHVRLILTKKETIDTVTDisGTTIIQRGIYCPPGAKpp----tGEKKLYFFIEGnsvLAVESAI 648  Tritrichomona...
OMJ88772      778 SSGKSFLE-LDINDYPLSARTRVMSRDYLNTINDltGSVVTVRGTYVDPSKKtg----iGQRRLHLFIEGptkQHCNSAR 852  Stentor coeru...
Q8H0U8       1063 MPEHYEAE-LEINDFPQNARWKVTHKETLGPISEwtGAAITTRGQFYPTGRIpg----pGERKLYLFIEGpseKSVKHAK 1137 thale cress
XP_001423312 1053 NNHDFVSYdFEINDYPTQARLKILSKEFLNMIHEltNCQISQRGSLVEPGKKpl----pGQKKLFLRIEGeneYFVMSAY 1128 Paramecium te...
XP_011773649  845 RNVRFEAE-YPINDLPNVVRLRLQNSAVLRSVAEesNSTIVRKGVFYDKSLKhshrlrdGVRPLYLLIIGktaESVRDTV 923  Trypanosoma b...
XP_002668937  798 INGLFRTE-VEINDWPRGPRSEVLKKDSLHSIQHftNTKIQIKGTYIPPETKpq----kGERKQYLIVEGadeGSVHQAR 872  Naegleria gru...
XP_650493     620 TNNGVQCK-IEINDFSIQARQVLTSKEKLISVMEncNVNITTRGSYIGEGKTpl----pGQSKLYLLIEGkneEDITKAK 694  Entamoeba his...
XP_002767294 1116 AADEVVEE-FEINDYPQLARAKVSNRELRGGIEErtGCRLQIKGQFYQKNAYvp----pGCRKLYIEIIGnsrVSCQRAK 1190 Perkinsus mar...
XP_018638281 1738 NTGNFVDE-FEINDYPQIARYKFTQRDVLSRLMEetGAVLYVKGQHVDPKEKhkvklapGAKYLHVEIIGatpIIVQRAR 1816 Toxoplasma go...
XP_001351645 1384 EDNNILEE-FYINNYPQHVRLKISHKDVLAKIADmsGATCQIKGQYSNPSQPnkqnfllDTKQLHIEILAptyNQIQIAR 1462 Plasmodium fa...
Q7L014       1003 AEITRLI 1009 human
A6ZLH6        826 ELLEQKV 832  Saccharomyces cerevisiae YJM789
XP_001582184  618 NRIEEMA 624  Trichomonas vaginalis G3
OHT02472      649 SQLQRMA 655  Tritrichomonas foetus
OMJ88772      853 NEIKRFL 859  Stentor coeruleus
Q8H0U8       1138 AELKRVL 1144 thale cress
XP_001423312 1129 KEIKRMA 1135 Paramecium tetraurelia strain d4-2
XP_011773649  924 KKLNSVK 930  Trypanosoma brucei gambiense DAL972
XP_002668937  873 TQILSVL 879  Naegleria gruberi strain NEG-M
XP_650493     695 KEIKNIL 701  Entamoeba histolytica HM-1:IMSS
XP_002767294 1191 AECRDVC 1197 Perkinsus marinus ATCC 50983
XP_018638281 1817 NECRQLL 1823 Toxoplasma gondii ME49
XP_001351645 1463 NELNSLL 1469 Plasmodium falciparum 3D7
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