Conserved Protein Domain Family
KH-I_KHDC4_rpt1

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cd22385: KH-I_KHDC4_rpt1 
first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein 4 (KHDC4) and similar proteins
KHDC4, also called Brings lots of money 7 (Blom7), or pre-mRNA splicing factor protein KHDC4, is an RNA-binding protein involved in pre-mRNA splicing. It interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. KHDC4 binds preferentially RNA with A/C rich sequences and poly-C stretches. KHDC4 contains two type I K homology (KH) RNA-binding domains. The model corresponds to the first one. The KH1 domain is a divergent KH domain that lacks the RNA-binding GXXG motif.
Statistics
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PSSM-Id: 411813
Aligned: 33 rows
Threshold Bit Score: 99.9742
Created: 19-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7Z7F0        99 KDDLVVAEVEINDVPltcRNLLTRGQTQDEISRlsGAAVSTRGRFMTTEEKakv--gpGDRPLYLHVQGqt--------- 167 human
Q09911       162 GDGVFMQDVEINNVRn--RYILVRASTLSEIENksGVQLFSKGRYYPNKALat----dKDPPLYLHIVShn--------- 226 Schizosaccharom...
ODQ72117     133 EDGDFIRDIEINHLMn--RYTLTKGQTQAMIKTetGADVTTRGRYYPDKSQat----eKEPPLYLHITSlt--------- 197 Lipomyces stark...
XP_018225226 127 QEGDYVKDIEVNDLRn--RYTLTKGSTQKMIKEetGADVTTRGKYYPDKGLat----eRDPPLYLHVTAtt--------- 191 Pneumocystis ca...
XP_023925473 121 QDGDYIKDIEVNDLRn--RYTLTKGSTQKMIKEetGADVTTRGSYYPDKSMat----pANPPLYLHVTStt--------- 185 Quercus suber
KLO12941      58 HDGEFTFDIDINECRn--RYLLTKGDTQKQIHDetGATVVNKGTWVPDRTKas----dRDPPLYLHISAht--------- 122 Schizopora para...
EPZ35763      45 GEYPYSTKIDINDSKh--RYNLARVQFHEMIFNdtGAIVICRGRFYPDRRMat----eREPTMYLHIASpn--------- 109 Rozella allomyc...
Q9LIA4        84 DEVIIAREIVINDAEaslRHRLTKRSTQEDIQRstGAVVITRGKYRPPNAPp-----dGEKPLYLHISAaaqlqlkette 158 thale cress
XP_011393475 118 SDGDFIKDIEVNDLRn--RYLLTKGSTQKMIKDetGADVTTRGSYYPDKSMat----pANPPLYLHVTStt--------- 182 Neurospora cras...
XP_004341137 124 KEEGVIAEVEINNCPpavRYLLTKGVTHQEIQQqtGATVISRGRFRPPHEAdlpvtspADRPLYLHVSAat--------- 194 Acanthamoeba ca...
Q7Z7F0       168 -rELVDRAVNRIKEII 182 human
Q09911       227 -rKDLTVALQEIESWI 241 Schizosaccharomyces pombe 972h-
ODQ72117     198 -kEGLEKAVGIVENLM 212 Lipomyces starkeyi NRRL Y-11557
XP_018225226 192 -kAGLEAAVKKIEELM 206 Pneumocystis carinii B80
XP_023925473 186 -kDGLEHAVRKIEELM 200 Quercus suber
KLO12941     123 -kEQLDNAIAKVNELI 137 Schizopora paradoxa
EPZ35763     110 -kEAMERAVEMINAVM 124 Rozella allomycis CSF55
Q9LIA4       159 riLAVDRAAAMIEEMM 174 thale cress
XP_011393475 183 -kEGLEKAVAKIEEMM 197 Neurospora crassa OR74A
XP_004341137 195 -qQEVDNAVSKINTLM 209 Acanthamoeba castellanii str. Neff
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