1J22,2BGW,4P0P,4M6W,2ZIU


Conserved Protein Domain Family
XPF_ERCC4_MUS81-like
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cd22367: XPF_ERCC4_MUS81-like 
XPF family DNA repair endonuclease
(Xeroderma Pigmentosum group F) DNA repair gene homologs are members of the XPF/Rad1/Mus81-dependent nuclease family which specifically cleave branched structures generated during DNA repair, replication, and recombination, and they are essential for maintaining genome stability. They belong to a wider superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411771
Aligned: 284 rows
Threshold Bit Score: 62.6626
Created: 15-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
active site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2BGW: Aeropyrum pernix XPF active site binds divalent cation; contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #                            #              # #                         
1J22_A      7 VVVDSRELRSEVVKRLkl------lgVKLEVKTldvGDYIIse-----dVAIERKSANDLIQSiidGGLFDQVKRLKEAY 75  Pyrococcus furiosu...
2BGW_A     11 VYVDVREERSPVPSILes------lgVQVIPKQlpmGDYLVsd-----sIIVERKTSSDFAKSlfdGRLFEQASRLAEHY 79  Aeropyrum pernix
RLG65912   16 IHADVRERRSRVIHFLke------mgAEVIEENllvGDYIVse-----rVCVERKTVGDLISSiytGRLFDECKRMRETY 84  archaeon
RLI18954    7 ICIDSNEASQRPEIVNylk----lsgCEVEVRRlpiCDYVVsd-----rCGIERKDAHDLANSlkdGRLFNQAREIAEAY 77  Candidatus Bathyar...
RLF19591    7 ITIDSREASIRVVRNKtikeyleelgLKVAVDVlpiGDYYLhakrkeecIIIERKTITDLANSirdGRLWNQLRALSEQK 86  Thermoprotei archaeon
OGV17678    4 IDVDFREKAETLINTLksl-----yeIEINTTAlkfGDYFIpp-----dTVIERKTTCDFLVSiidGRLFNQAYRLAEHC 73  Lentisphaerae bact...
PVU71646  543 IIVDYKEKESGVVQTLan------tdILIKLENldvGDYIIg------dLIIERKNILDFINSiidGRLYNQLEKLKDKK 610 Candidatus Nanobsi...
KKK45204   13 VVVDAREHKLKALLDKkk------etITYESKQidiADIVIss-----eTAIERKEGSDFVSSimdNRLFEQMLRLKETY 81  Lokiarchaeum sp. G...
PNV81348   27 VVVDSNEEYHSERVIKelk----rlgMRVAVSKleaGDYFIplgseprgFLIERKRVDDFINSildSRLWTQAESLSKIS 102 Fervidicoccus sp.
ADG90611   17 VIIDSKEDSKHPDAKKklm----aagLKVAIQNlpaGDFLLlspperqsILVERKTVDDFANSirdNRIWEQAKLLKNAS 92  Thermosphaera aggr...

Feature 1                                                               
1J22_A     76 s----rPIMIVEGslyg-irnvHPNAIRGAIAAVTVDFgVPIIFSStPEETAQYIFLI 128 Pyrococcus furiosus DSM 3638
2BGW_A     80 e----tVFIIVEGppvprryrgRERSLYAAMAALQLDYgIRLMNTMdPKGTALVIESL 133 Aeropyrum pernix
RLG65912   85 p----iPVLILEGylpl--ifkISKIPASSVWGALSSIiLNFNVRVlPSPNTMSTAGI 136 archaeon
RLI18954   78 e----rPILILEGrlta--vlrRSRMRPSSLYGALASLaLDYGFSIiPTADAYATSVL 129 Candidatus Bathyarchaeota archaeon
RLF19591   87 eng-isVILLVEGwikl--lekFTKWRPQAILRLLETIqVKYGIPIvYSPSWDWTALY 141 Thermoprotei archaeon
OGV17678   74 k----rPIMLIEGetff--gekYPDLSKEAIKGALITIaQTFYIPVlRTTSESDTAWY 125 Lentisphaerae bacterium GWF2_38_69
PVU71646  611 ------SVLILEGtdds--lgiDTNISINYIRTLILKIiLEYKIPIiRTSDFLETANY 660 Candidatus Nanobsidianus stetteri
KKK45204   82 p----nPILIIEGlndk--vfnKTGMKISSIYGALAYVsYKMGIPViPTRNLADTAIV 133 Lokiarchaeum sp. GC14_75
PNV81348  103 kesnmdVVFLIEGdlwd--ameNREIPQLAVIRAIDEIvLTFKIPIiYTKDPEMTASW 158 Fervidicoccus sp.
ADG90611   93 vkdghkPLIVLEGclee--lanYRGWRPQSLLRILDTLiLEFEIPVlNTPGLEETLQW 148 Thermosphaera aggregans DSM 11486

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