2INB,2OKF


Conserved Protein Domain Family
XisH-like
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cd22366: XisH-like 
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Endonuclease XisH and similar nucleases
XisH functions as an endonuclease in the control of expression of nitrogen fixation genes of certain Anabaena and Nostoc species of cyanobacteria. Together with XisI, it controls the cell-type specificity of the excision of the fdxN element by the recombinase XisF. XisH belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411770
Aligned: 85 rows
Threshold Bit Score: 156.48
Created: 13-Feb-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative active
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                            #                   # #                 #   
2INB_A         6 DVFHQVVKIALEKDGWQITNDPLTISVGg--VNLSIDLGAe-KLIAAEREGEKIAVEVKSFLerssaISEFHTALGQFIN 82  Nostoc punctifo...
WP_059001422   5 DKFHQAVRQALIQEGWNITDDPLLVRYGp--TNLKVDLGAe-RIIAAQRESEQIAVEIKSFLda-stVNDFHAAIGQYLH 80  Leptolyngbya sp...
ADB37594       4 DIFHEAVKVALQKEGWTITHDPLMLEAFg--TQIYVDLGAe-QVIAAQRNTELIAVEIKSFLgn-syVYDFYQALGQYVA 79  Spirosoma lingu...
OJW80857       4 DLFHELVREALEADGWIITHDPFVLKSGg--LRLEVDLAAe-QMLAAELGHEKIVVEIKSFIgk-skLNDFYEAKGQYDV 79  Spirosoma sp. 4...
OJW80494       4 DIFHPIVREVLLNDGWVITHDPYPIRVKg--RNYEVDLGAe-QLMAAEKDTRKIAVEVKSFLlp-sfSHEFHAVLGQYLN 79  Spirosoma sp. 4...
WP_109744941   4 DIYHQIVKEALEKDDWLITHDPYLLNRStksKPYEIDLGAe-KILIAERGVEHIAVEIKSFLgs-svTYDFHAAFGQYGI 81  Arcicella auran...
OCR02499       5 DNLHLSLRRTLEKDGWTITDDPLILVLEq--TLLKADLGAe-KFFAAEKEGRKIAVEIKDFDsp-svINELEKTMGQLQL 80  Oscillatoriales...
WP_016924837   5 NQWHDALCHALEQEGWGITRDPLPLVVNpevKRHPVQGGGd-SVVAADRGDEHIAIEVKSFGqd-saIVRFYEALRQYLS 82  Prochlorothrix ...
WP_020596546   5 DLYHQAVVKALEADGWMVRKDPLAITFLn--RTVFVDLGIegVSLIANRSGRKIAIEIKSFLst-spIKDFQEAIGQYLM 81  Spirosoma panac...
OJJ25138       5 DRYHDIVRNALIKEGRTITHDPLILGDLe--HRVYPDLGA--EKRASDRQSINLAVEIKVFGni-gqISELEKAIGQYVL 79  Roseofilum rept...

Feature 1                                                                  
2INB_A        83 YRGALRRrqpeRVLYLAVPltTYKTFf-qLDFPKEXIAENqVKXLIYDveQEVIFQWI 139 Nostoc punctiforme PCC 73102
WP_059001422  81 YQLGFKYngwsRKLYLAVPleVYRTEf-dKPLYQDSLQAFkVKILVYRteNPGIEQWI 137 Leptolyngbya sp. NIES-2104
ADB37594      80 YLRALKLsepeRTLILAVPlkAYKGFf-tKPDVQASLRDFnLNILVYDnkKEIIVHWF 136 Spirosoma linguale DSM 74
OJW80857      80 YRRGLKKegvqRKLYLAVDvdVYETFf-qKSLIAELLEDElISLLVYDipMKRIVQWI 136 Spirosoma sp. 48-14
OJW80494      80 DQTFMEIqepdRTLFLAVArnIYDKFf-lDEATQLIVDKFkLNLVIFDkqTKKVEEWI 136 Spirosoma sp. 48-14
WP_109744941  82 YRYFLENkdpeRKLFLAVTeeIYQSFfkdIDIENLCIHFN-INLIIFDseHKNITQWI 138 Arcicella aurantiaca
OCR02499      81 YQWALENqepeRQLFLAISqaVYIRHf-qKPIFQLAVQRNrINLLVYEpeREAIVQWS 137 Oscillatoriales cyanobacterium USR001
WP_016924837  83 DRTLLQHqypqYVLYLAVPleIYNSFf-sTPLARAIMNSEdLNLIVYNphLQQITHWI 139 Prochlorothrix hollandica
WP_020596546  82 YELILNEtdpeIELWLAVPvaVYDEFf-lEEFTLFVLSKIsISLVIFDqvASKIVKWI 138 Spirosoma panaciterrae
OJJ25138      80 YRSILQRsrstRQPYLAISstIYQQLf-qKTIIQNLIEDEkIRLIVFNpdLEEIEQWI 136 Roseofilum reptotaenium AO1-A

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