1XMX


Conserved Protein Domain Family
VC1899-like
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cd22364: VC1899-like 
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putative nuclease domain found in Vibrio cholerae VC1899 and similar proteins
A putative nuclease domain found in Vibrio cholerae VC1899 and similar proteins belongs to a superfamily of PDDEXK nucleases that includes diverse members such as very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411768
Aligned: 93 rows
Threshold Bit Score: 289.119
Created: 22-Jan-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative active
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: putative active site [active site], 4 residue positions
Conserved feature residue pattern:E D E KClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1XMX_A         4 AIHVGIIdQDPVRLVTPLLDhrtvsrHIIFIGdhtQTVIYQRLSDVLNKRNi------sTDFFEipa--gsnTSAIKSAI 75  Vibrio cholerae
PXF30854       6 DIHLCLMsDQATPNLTPLLEkgiapvAVTFVVtpqQKHRLDYFQEVLRPRNi------kVEMLElds--aydHDAMTALL 77  Pokkaliibacter ...
WP_044413438   5 HIHLCLVsKQPTPNLVPLIDpnlqvdEAILLHtdsFKQHALWLQQALAMYQi------kTRLDVlps--adnMHQLHDFL 76  Thiomicrospira ...
WP_127477116   6 TTHLYLVsDQPTPNLTPALDpalkpqRVILAVtkdLQRKAGWLRGVLERHGi------pCETLNv------dDAYDFAAL 73  Sulfurivermis f...
WP_012638362   5 QTHVYLVsDQATPNLTPALDp-----DIRPERa-vLAVTPQAEHQARWLTTvle--rhgVHCERlslddaydLDSLRQSF 76  Thioalkalivibri...
WP_137938126   5 HHMISLVtDSGTQAITPAFDqrfgiqHITLLSmpsLMDRAHRLAETCRQVGk------aSDVEQmvt--rwkPQALREQL 76  Chitinivorax sp. B
WP_136771706   1 MHLICLVgYVSTDLVSPLFDrgfgftRVTLLHdpaIGDAMRAVADVCRKAGl------aTTVLPl------rPRYDPATI 68  Chitiniphilus e...
WP_148717031   1 MHLICLVgHVSSDLVSPLFDrgfgvtHVTLLYdsaLSEAIQHVAAVCRQAGva-----tTALPLrp-----rYDPATIRE 70  Chitinolyticbac...
WP_017508279   1 MHLLAFVnRVESDIITPALD------RRFGVS---QVSLLCHRSELGLATDiagv-crsLHLPAnv-----vTLAPDTQP 65  beta proteobact...
WP_047966364   1 MHLLAFVdHVVSDIITPALDpr---fDIDRVT---LLCHRAHLDLAFDILGvcqklhltAAVETlp-----aDSQPLALR 69  Vogesella sp. EB

Feature 1                                                                                        
1XMX_A        76 RELAETLKar--geEVKFNASCGlRHRLLSAYEVFRsy-hWPIFVVEPn-sDCLCWLyp-----egNNDTQVQDriTIAD 146 Vibrio cholerae
PXF30854      78 DGWLAVQKka--gkSVWFNLTGGtKPMSIAAHLVAFna-dIPAFYISD---NRLLWMnakp-vsddMLPAELASklSFVT 150 Pokkaliibacter ...
WP_044413438  77 IQLYEKLKqetpdsKIYCNITSGtKTMSIALYELALmtadEGTQAYYQnldDTLSWYvp-----ltTERHEIIDrvKIKP 151 Thiomicrospira ...
WP_127477116  74 RRLFARVAdd---pSCAANITGGtKPMSLAAYEAFLka-dRPVFYVNPk-tDTALWLhp-----pgQPQHPLADkvLLED 143 Sulfurivermis f...
WP_012638362  77 RSYLQRCTe-----PVAVNVSGGsKPMSIAAFEVFAha-dQGVFYVNPr-tDTLDWLhp-----tgIPAQAIADrvGLED 144 Thioalkalivibri...
WP_137938126  77 QHILSGCNv----aHLIINLSGAtPVEAIELAQLARsm-tIPAFVIEPe-vDKAVWIerpassstrMPELDVADtlSLSQ 150 Chitinivorax sp. B
WP_136771706  69 RERLEATVaas-rqPCVLNLSGAtPVQAAIGFEVGSrh-aLPMFAVEPe-aDTLVWLsdaa-aaplANGYNIADrmRLEE 144 Chitiniphilus e...
WP_148717031  71 RLEAVIVGsr---qPCLLNLAGAtAVQAAIGMQVAEaq-rLPAFAIEPe-aDTLVWLsrpe-gaplANGYNIADtmRLED 144 Chitinolyticbac...
WP_017508279  66 LALRQQLAala-qgAVAFNISAAsPVQAALTYDLARer-qLPLMSIAPh-sDRLIWLlgge-htglRTGSDIADglTLAA 141 beta proteobact...
WP_047966364  70 QRLQELVQg-----GVCFNISAAsPVQAALAYDLAReh-rLPLMAVEHd-nDRLIWLlgge-ssrlHSGTEIAEglSLEA 141 Vogesella sp. EB

Feature 1                                                                                        
1XMX_A       147 YLTIFgaRGEfnehqlspqlDQQLYQLGERWASNa----lELGPGLATLNYLATTCRKEqkLDVELSDKQqgyRELNLLL 222 Vibrio cholerae
PXF30854     151 FLTAHgiKVEgtqs---idsPVPWRELIRELCRLh----sTYHKVIPFLNRLAAMAKPG--LTARIDAVLt--VDHEQLL 219 Pokkaliibacter ...
WP_044413438 152 FLLSHgvDTLnqsh---srvAPQWRPLIDELVMNl----sQYQSAISTLNFHAVSASYNp-NLVSENEIKsrfPSLNALL 223 Thiomicrospira ...
WP_127477116 144 FLAAH--GMPvtqlrrteaaQAKVDAAAQLLARTl-----RRPNLAGLLNVYASANAGN--DNVQLSEGQl--RALRPLL 212 Sulfurivermis f...
WP_012638362 145 FLEAHgaSVHhlsr---qaaPASRLALYEEIVRLrg--rwKKHGSIGLLNRYAQGARETlrSEEISPEHQrllNELPGLF 219 Thioalkalivibri...
WP_137938126 151 YFIVH--GYQlnha---matLKQRNYRAERIAKFm----aDLAVHSPRTLLRLNRAGAE--LDENLRSFIhfdASDWHAL 219 Chitinivorax sp. B
WP_136771706 145 YFRLY--GAEivtv---ecrLSQRDAALEGWAAGfaelaaYRPRAILALNALAADVDAGwiSRGALHHPQ---PELAELL 216 Chitiniphilus e...
WP_148717031 145 YFRLYgaAVVsse-----srLDKRNPALEAWAGEmarlavRQPRTILALNALASEVDAQrvTLGRLHQRQ---PQLEALL 216 Chitinolyticbac...
WP_017508279 142 YFALYgsRIEhihyr-lsqrPQRLEALAAGLVTLa----vQRPTALSLLNRLCNDLDTRqfSRHPLPRGE---TALRHWL 213 beta proteobact...
WP_047966364 142 YFALYgsRILaihyr-lerrSPHHEDLARDLAEHa----aLRPKSLSLLNRLCNDLDEQqfSQHPLSSGE---HVLYDWL 213 Vogesella sp. EB

Feature 1                                          #                                         #   
1XMX_A       223 SDLvea-kiaSYEn-GILTFinEEARRFANGEWLETLVHSTVKQIqddmptiqDRSLNVQVYRQlg--erEVRNELDVAT 298 Vibrio cholerae
PXF30854     220 KVFeqa-gllSWTr-ESVTFpdEDARFFCNGGWLEHHLMQTVRSSga----vqDMAMSMEVSYVrpkvrkTVKNEIDVAV 293 Pokkaliibacter ...
WP_044413438 224 KLLqdh-gliQWQg-PYIKFpsEQARFFCAGGWLEEHVYHTIRKMmaknkriqDLAQGLEVYSLlqgkanTIKNELDVAV 301 Thiomicrospira ...
WP_127477116 213 AILern-qiaTRQg-ENIVLpnQEAITFTSGGWLEELAFATVAKLrlllpqvqDIACNIKISAGtg--eeHMQNELDIAV 288 Sulfurivermis f...
WP_012638362 220 AEQgl----lSWEg-TRLVFpdEQARRLVNGVWLEEYLFSRLLALkdslpamqDLAANVVVRRNtd--ngYVQNELDVAL 292 Thioalkalivibri...
WP_137938126 220 GFLaesgylrWHHq-DRVQFasGEARNFLCGGWLETFVFATVAELahkl-piqDAATGVIVTTQd-----RVSNEFDVAL 292 Chitinivorax sp. B
WP_136771706 217 HESrl---arLLPd-GRIAFadRPSHRFLHGGWLERWIFSQAGALvgel-piqDLACGIRIRVDg-----KVDNEFDVAI 286 Chitiniphilus e...
WP_148717031 217 ADSgla--rvLPD--RRIAFadVSAHRFLHGAWLERWIFAQASALmgel-piqDLASGIRIRVDg-----LVDNEYDVAI 286 Chitinolyticbac...
WP_017508279 214 GSCgl----vDMDqaGHVRChdASARFFLGGGWLEVWLLSQVAALqptl-pisDAAVGVKVVHD------GVANEYDVAI 282 beta proteobact...
WP_047966364 214 LASgmv--efRDS--GHMRCldPRARFFLAGGWLEVWLLSQVAELaqil-pisDAAVGVKISHH------NVENEYDVAI 282 Vogesella sp. EB

Feature 1                 # #                                                                    
1XMX_A       299 VVNNKLHIIECKTKgmr----------ddGDDTLYKLESLRDLLggLQARAMLVSFr-PLRHNDITRAEDl--GLALIGP 365 Vibrio cholerae
PXF30854     294 LANNTLHLIECKTKrfggna---qdpdsdLSSALYKLATLRKELggLRCKAMLVSYg-PVEEFQKERARVl--DIELCQG 367 Pokkaliibacter ...
WP_044413438 302 LVNNRLVVIECKTYqtdk-------enspVPDSLYKLDTLASQTggAFGRGIFICLn-PLKPNDYERAKRy--NIEVIQG 371 Thiomicrospira ...
WP_127477116 289 LRDNTLYLIECKTEnyskqanpnamlyqnPNAVLYQLESLTRATggIKARGLLLSLh-DIKQGNRRRAEAs--GLQILAG 365 Sulfurivermis f...
WP_012638362 293 LLDNRLWVLECKASntfapq---nrvdqaTRQSLYKLEALLTPLggILARGMLVNVl-PIGVNDQRRIDNnprLCALTYR 368 Thioalkalivibri...
WP_137938126 293 IANNQLYLIECKARgprr-------asgvGMDTLFKLDSLAGQMg-LNSRAMLVSLa-KPTHAEQMRAEAq--GIEILAG 361 Chitinivorax sp. B
WP_136771706 287 LCNNQLYLVECKTIlae----------gvDRATLFKLDSVAHVGg-LAAQAMLASLs-LPTDHEERRAEVq--DIALLSG 352 Chitiniphilus e...
WP_148717031 287 LCNNQLYLIECKTVfgr----------gvDRDTLFKLDSVTHIAg-LSAEAMLASLslPTEHEIDRAGAH---DIALLSG 352 Chitinolyticbac...
WP_017508279 283 LCNNQLYLVECKTTaptal-----hqrgiGLDNLFKLDSAASLGg-LHARAMLATLy-PATESEAARAQAq--GIALLSG 353 beta proteobact...
WP_047966364 283 LCNNHLYLIECKTAaptsf-----qqrgvGLENLFKLNSVAGLGg-LHAKAMLASLy-VPTESEVGRAESq--RITLLAG 353 Vogesella sp. EB

Feature 1                      
1XMX_A       366 dELKDLKTHLTQWF 379 Vibrio cholerae
PXF30854     368 dDMMRLDEKLKSWI 381 Pokkaliibacter plantistimulans
WP_044413438 372 dRFAQLQTALERFI 385 Thiomicrospira microaerophila
WP_127477116 366 -PQLEALPGGLHKF 378 Sulfurivermis fontis
WP_012638362 369 -DFDDLDRHLHARL 381 Thioalkalivibrio sulfidiphilus
WP_137938126 362 gRLLRLSEELQQWL 375 Chitinivorax sp. B
WP_136771706 353 rALLGAAARLRQWL 366 Chitiniphilus eburneus
WP_148717031 353 sALLQATTVLRRWL 366 Chitinolyticbacter meiyuanensis
WP_017508279 354 pALAHAQPVLRQWL 367 beta proteobacterium L13
WP_047966364 354 -PQLRQAREYLREW 366 Vogesella sp. EB

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