1F1Z,1T0F


Conserved Protein Domain Family
TnsA_endonuclease-like

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cd22362: TnsA_endonuclease-like 
Click on image for an interactive view with Cn3D
Transposon Tn7 transposition protein TnsA
TnsA is part of the Tn7 transposon mobile genetic element working together with TnsB, TnsC, and TnsD to facilitate insertion of the transposon. TnsA catalyzes cleavage at the transposon 5' ends, and TnsC is the activator of the composite TnsAB transposase. TnsA belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Statistics
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PSSM-Id: 411766
Aligned: 62 rows
Threshold Bit Score: 143.236
Created: 28-Mar-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
active siteTnsC binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                   #                  #                 
1F1Z_A        28 DYIPWLTVQEVps----sGRSHRIYSh----kTGRVHHLLSDLELAVFLSLEWEssVLDIREQFPLl------------- 86  Escherichia coli
WP_108750442  25 DYRPWIQITRNrssplsnLRVTQIPY------MRRSLHCLSRGEAHMVHYLRWLg-ASDIREQYPMwnw----------- 86  Stenotrophomona...
WP_021005340  47 DYKPWLRVTKKd-----ySPSSFIGHlps-pgTGHKHHYRANGERSMLLLLKWLg-AIDTRDQYPAwpwahnhaic---g 116 Variovorax para...
OGB04842      67 TYQPWIRIRKNfs----sPTSYQVFDsv--glNARNHHFLSQLEFHTALLISYLg-AAELRECLPLwpfehphpetgldd 139 Burkholderiales...
PZP94774      24 LYQPWIRIRRKl-----tSKISKLYArhv-pmHHRLLHLLSGLEDDAAHVGAWLq-AIEAREQFPMwpdehlhpdesfss 96  Variovorax para...
OEZ62084      56 HYLPWLTLRKKnpsphsnQVISRMPP------LGRTAHYFSRGEYHTALFLLWLg-VEDLREQFPIwpiphphpldlygv 128 Duganella sp. H...
SEF22285     122 NYCAWIRIRRHls----sPVSTLHVEhtp-lySHRGLHLLSDDEDRMARIFVWLg-AIEVREQMPMwpdphrlplfgwhp 195 Variovorax sp. ...
PZR20243      46 RYKPWLRVTKRd------LSPNSVIGhlpaptLGRTHHYRSIAEKETIHIAKWLg-AVDVRDQFPAwpwmhqhpgv--gl 116 Citrobacter fre...
EKD97905      33 DYRAWIQLRRWna----sPVSVQTFGsl--ppFQRSASFLSRSEWLLALVLSWV--GCHVREQFPLwpwahmhplygrwi 104 uncultured bact...
KIN89083      27 FYQPILQIKRWntspvsvQVVETLPP------FRRRCHFFSYSEYHMALLFSWA--GALIREQFPAwpwphfhpehgrnf 98  Thauera sp. SWB20
Feature 1                                                             #                  # #     
1F1Z_A        87 --------PSDTRQIAIDSGIKHpvi------------------rgvDQVMSTDFLVDCKdg---pFEQFAIQVKPAAal 137 Escherichia coli
WP_108750442  87 ------phAHPLAQLREDLGCGEmhpgmaavaekaqfvlrtypgtdiRTVLTMDLMVTVPaei-nkARLVAISCKPLQrv 159 Stenotrophomona...
WP_021005340 117 lpgtelirVRGLMDIANDLGVEHglyv----------------gtdvPYVATIDILATWQhad-gnYYLTAHDCKPEElm 179 Variovorax para...
OGB04842     140 dldlwhdpAPGLLEIAKSAGIEHgnfv----------------gttvPYIASIDLMFRVRha--rkWRLFGISCKPKDit 201 Burkholderiales...
PZP94774      97 pyggltsrVEGLMSIAKRVGIDHgyyv----------------gtkiPFVATMDFMWGLPql--dtPKLVAWSCKPKDqi 158 Variovorax para...
OEZ62084     129 aqdkprpwSRGLLAIAAAAGVEHgvef----------------gtnvPYVASLDLLATTRlg--grSALTIFSSKPIDsp 190 Duganella sp. H...
SEF22285     196 drdrslgeAPGLLEIAKKAGIDHgryy----------------atkiPFIATTDLMVRFGip--pdDRLILCQCKPRKia 257 Variovorax sp. ...
PZR20243     117 pgfdgiskLRGLISISKEAGIEHgnyi----------------gtkiPYVATIDLLTTWIspd-kkYYLIALQNKPEKis 179 Citrobacter fre...
EKD97905     105 ardealrrSSGTRELCRRAGISHgtfl----------------gtsiPYIWTLDLCATLAwlppeqQTCALVSVKPLHge 168 uncultured bact...
KIN89083      99 eddallarSPGMIKICRDAGIGHgtfv----------------gtdiPYIWSIDLCLTLPwievpaQRTVLASIKPLDsd 162 Thauera sp. SWB20
Feature 1                                                                                        
1F1Z_A       138 -------qdERTLEKLELERRYWQqkqIPWFIFTDKEINpvVKENIEWLYsvkt------eevsAELLAQLSPLAHILQE 204 Escherichia coli
WP_108750442 160 le---gredDREIQRLELDRLYCEagkIPFVLAHPEQLPrtLIVQLEAYGpvgdpdryrvlassSEYADFVDRLDSLVYT 236 Stenotrophomona...
WP_021005340 180 rq---dgdfSRLKQRLALIHRYCEessIRYCLTHSERLSpeLLRSLDVLHplltq----damvaLRQSHLYQTVVNACMR 252 Variovorax para...
OGB04842     202 e------qsTRAQERIELDRLYCTavgAHHHHEDGSSFNteLILQLRSLRptvsfl--rahqrtNRLQDFVGKFNDYAND 273 Burkholderiales...
PZP94774     159 dd----enrVRMRERMQLEYLYCEqcsIPYRVIDGSHWTqlVADQLRWLQpvrsql--kqlrrgSRLGDFGARFMELCED 232 Variovorax para...
OEZ62084     191 gd----dvkWRTLERLELERRYAIdiaARYYVSSAALISvlTAGQLENWLdasn------lryfPHLENYAAPFAASFNE 260 Duganella sp. H...
SEF22285     258 ea----pknSRTRERLILETLYAKaigACAAVIHEDYLPsvFHENLIWLEplrsei--lsartsQQIFDYAHAFMRRCDS 331 Variovorax sp. ...
PZR20243     180 ks---ptpnTRPKQRLEIIRRYCVesnITHIIIHAENFPreLSVNLEFLEpnlrt----heiqsIANSHLYKRVLHELKI 252 Citrobacter fre...
EKD97905     169 lytgdidpiARGPEKLEVERLYALeldLPYFLADRHIYPgaLLGNLEWLSnaamvp--pdhpvtVTLPQFLQSHGHVLHR 246 uncultured bact...
KIN89083     163 ryq-hvdplDRGPEKLEGERRYARqlgVGYIVADRTQYAgpLFANLDLYRraatla--pnsrlaSARDNLLVGHAQDLQA 239 Thauera sp. SWB20
Feature 1                                                                         
1F1Z_A       205 Kgd-eNIINVCKQVDIay---dlELGKTLSEIRALTa--nGFIKFniyksfrankcaDLCISQVV 263 Escherichia coli
WP_108750442 237 R----PAMQAARRAAKgl---pwDHDTMVSALRTSIw--hQHIDVdl--------atQISLARPL 284 Stenotrophomonas sp. ZAC14D2_N...
WP_021005340 253 RayerPVHAVVTELATrl---vlDFEACKQALAAAIw--fQDLDHdv--------sqPLETWHPL 304 Variovorax paradoxus
OGB04842     274 R----FVSDAALAAGQev---glHRDDAFAFFRLGVw--lHLIDIdl--------tqRVQMRKPI 321 Burkholderiales bacterium RIFC...
PZP94774     233 R----SITEASNKVAVem---glELDEKNRMFQAAVw--tGHINAdl--------rfPIVMSHRL 280 Variovorax paradoxus
OEZ62084     261 S----KVLSILEAVNKaasqcslDLDQAWFLFRHCAw--tQAIDIdp--------tvRILHSYPA 311 Duganella sp. HH105
SEF22285     332 D----PIEACVEHAASst---gmDLITGHASFRMAAw--aGLIDAdl--------lqPIQMTRLL 379 Variovorax sp. NFACC28
PZR20243     253 NgysdPPQKIINHLAS-------RNKSQLSILYKLLhlalWRTDIdhd------ltlPYRPCDPL 304 Citrobacter freundii
EKD97905     247 C----PPSEWRQRFQAdf---glSIEEADLAVQHIIw--hQYVDVdl--------scDLNFDVIA 294 uncultured bacterium
KIN89083     240 Q----PIADSIRLAAEac---giSHADATTLLHHCLw--tQAIDCdl--------srDIHPAKPP 287 Thauera sp. SWB20

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