Conserved Protein Domain Family
SfsA-like
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cd22357: SfsA-like 
Sugar fermentation stimulation protein A and similar nucleases
Sugar fermentation stimulation protein A may bind to DNA in a non-specific manner and may act as a regulatory factor involved in the metabolism of sugars such as maltose. However, it contains a well-conserved PDDEXK nuclease active site and may have hydrolytic activity towards an unknown target. The putative catalytic domain belongs to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411761
Aligned: 48 rows
Threshold Bit Score: 263.633
Created: 28-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative active
Feature 1: putative active site [active site], 4 residue positions
Conserved feature residue pattern:D E K HClick to see conserved feature residue pattern help
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
RLB09142   19 VFVKRPNRFLGIVDinglektklveVHVHDPGRLPDILTSGNRVRLRya--asKKRKTRWDLIAak--nNGNWVLVHSGY 94  Deltaproteobacteri...
AEA46441   10 NFIRRDNRFLVTVEingr----pvkAHLKDPGRLKELLVEGNRVLLKer--dgKNRKTRYDVIAi---yAGVPVIVNSGL 80  Archaeoglobus vene...
TDA38942   29 VFISRLNRFTVLLEyegr----dlmCHLHDPGRLRELLVPGAPILFReaqtkgSRRKTRHDVLAvh--sSGNWVITDSRM 102 Candidatus Verstra...
RLG38190   11 RFRSRPNRFTVVLEtpkg----trrCHLRDPGRLTEILIPGARTIFLer--sgPGRKTDCEVLAvw--sGTWWTVVNSGL 82  Candidatus Korarch...
PMP75665   15 HFKNRLNRFAVETEeg-------kiCHLHDPGRLEELLIPGREIYAIr-----KYKGLECEIIYtk--vEDEFILINSKY 80  Aciduliprofundum sp.
ADX84033   34 HVVERINRFLVKVTfngk----eflAHLHDPGRLKDLIYPGNLVLIRe----tKGYKTKFSITAay--sNSRFVVLDSRL 103 Sulfolobus islandi...
KUO92466   17 VIIDRPNRFTVLTGsg--------aCHLHDPGRLLDLVYPGNKVLIRd----wRGEKTNCRIAAawssdSGEWVVIDSGI 84  Thermocladium sp. ...
KJR73699   19 EILERPNRFVVRVVdggr----erlCHLHDPGRLPELVRRGAKALVRp----tRGAKTDCSITAie-apNGVWVVADSRI 89  Thermoproteus sp. AZ2
OWP55997   27 RVIDRPNRFIVNVScgnl----qlvCHLHDPGRLKELIFKGNRVLVRp----tTGKMTKYSITAaw--eNSRWILTDTRV 96  Thermoplasmatales ...
EQB70220   29 RIIDRPNRFLVVAHngke----eirCHLHDPGRLKELIYPGNTVLIRq----qAGAKTGYSVTAar--aGSQWVITDTRF 98  Thermoplasmatales ...

Feature 1                                       #             # #                      #      
RLB09142   95 HRKICEELFRkpeispfkgiegfkaevKLGKSRIDFLLetndrgkIWVEVKGCTLANGKVASFPDAPTTRGARHLEELia 174 Deltaproteobacteri...
AEA46441   81 HSALAEKIIPqifrcg-----iakrefTFLGSRIDFLLdc----hALLEVKGCTLVKDSIAYFPDAPTERGLKHILTLik 151 Archaeoglobus vene...
TDA38942  103 PNYILKRAIElsifdyk----vvaeevKYGDSRIDFLLerd-gvqYITEVKGCTLCRDGVALFPDAPTSRGSRQIMRMle 177 Candidatus Verstra...
RLG38190   83 HTDLATELILsgavpelpadapirrevRFGDSRVDLLLgts--ppTLVEVKGCTLVVDGVALFPDAPTERGTRHVLNLir 160 Candidatus Korarch...
PMP75665   81 HNSIAKNIIEkgllgknf--klkkseiKLNDMRIDFLLdfn-ekdYYLEVKGCTLLDGEFAKFPDAPTRRGTHHLKKLae 157 Aciduliprofundum sp.
ADX84033  104 HNIIASKFLPeaye----------keiKVGNSRIDFKYd-----nTYLEVKGCTLVENEIAYFPDAPTERGRRHLKELre 168 Sulfolobus islandi...
KUO92466   85 HSIIASHFLPgklq----------revKIGHHRLDFLWg-----sTYVEVKGCTLTINGKALFPDAPTRRGTNHMKLLke 149 Thermocladium sp. ...
KJR73699   90 HSDIAALFLPgae-----------revKVGGRRLDFKLg-----dEYVEVKGCTLVENGRALFPDAPTRRGAEHMGLLka 153 Thermoproteus sp. AZ2
OWP55997   97 HSQIASLFLDsksr----------revAVGRKRIDFMLe-----nHFIEVKGCTLVAGGIAKFPDAPTKRGREHLDLLad 161 Thermoplasmatales ...
EQB70220   99 HHPIARHFLPpdvr----------sevRVGNHRIDFMYg-----dTYLEVKGGTLLENGIAVFPDAPTTRGRDHLRLLlq 163 Thermoplasmatales ...

Feature 1                                                                            
RLB09142  175 ikdQGDHAAILFLVFrpeslcFLPNVDIDPDFSAVFRkAIKCGVEVRFLVLEYADSgvy----yrREIPLC 241 Deltaproteobacteria bacterium
AEA46441  152 ameMSYSSKILFLVTrpdarvLKPNRETHPEFADALNeAMNKGVEVRAVLLELVLKgheaeivlkGEIPVK 222 Archaeoglobus veneficus SNP6
TDA38942  178 --yPGARPLLVFVIMrpdartLRPNVGTDPKFYEIVReGITRGLSTISFKVSLEDGrfi---wfrGAVPVV 243 Candidatus Verstraetearchae...
RLG38190  161 avrSGMRAAVLFLVMrpdaerLEPNEETDPKFAEALRsARREGVALLAHRFRLRGRvie----pvGGIPVV 227 Candidatus Korarchaeota arc...
PMP75665  158 lrrDGYGAGVLFLVFrka-ryFMPNYERDQDFYYALIdAVRWGVDIFPLRLYFDGRrff----alGLIEIK 223 Aciduliprofundum sp.
ADX84033  169 lmkKGFNAILLILVMrddakcFLPNEKTDPEFSIEFWnSINEGLNVNIKTFKLVGNkii----yvRDIPLC 235 Sulfolobus islandicus HVE10/4
KUO92466  150 lreGGVEGLVMFLVMrra-kcFAPNWGMDPAFSAALRdAINAGVSIWVKSFRLSGRsii----ytGDLELC 215 Thermocladium sp. ECH_B
KJR73699  154 lleAGYKARVVVLVMrpdaecFSPNWRTDPRFSRAFAeLVSAGASVDVLRFRFEEGrvv----fdKRIELC 220 Thermoproteus sp. AZ2
OWP55997  162 lvkTGHEATVLILVMrddaicFVPNENTDPDFTRSFFnALNAGVRLKILKFAFKQNsvv----fmGEINLC 228 Thermoplasmatales archaeon ...
EQB70220  164 lmlQGYGAELMVLMFrrdataFMPNSRTDPDFSREFYrCLDAGMPVRVLKFAFDGLhvt----ycGRIPVL 230 Thermoplasmatales archaeon ...

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