Conserved Protein Domain Family
Sau3AI_N-like
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cd22356: Sau3AI_N-like 
N-terminal catalytic domain of type II restriction enzyme Sau3AI and similar endonucleases
Sau3AI is a type II restriction enzyme that recognizes the 5'-|GATC-3' sequence in double-strand DNA (| denotes the cleavage site). The N-terminal domain modeled here conveys the catalytic activity, it belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411760
Aligned: 77 rows
Threshold Bit Score: 145.395
Created: 7-Jan-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative active
Feature 1:putative active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                #             #        # #              
P16667        18 VGKSVLELNGGesi--------------kqSKSSVG-DAFENWFgKKKDSDSKPDMa--eAGVELKATPFKKlk------ 74  Staphylococcus ...
OIP83251      21 KGKTISQIKIElnle-----------rvnmKKGASGlILETLLG-LPNNNTADADIs--eIGCEVKILPIQRnk------ 80  Porphyromonadac...
OFX49284      10 LSPLFEIIKNSkgktikqikqelnlerenmKKGASGlIVENLLG-IKNNNNADADLp--eIGCEIKVLPLQKnk------ 80  Bacteroidetes b...
CAC27338      19 VGKTLGQIDKNnvfdkt--------kekpkITGIAGdVIEQCVFgYQADNKQEADLlidgRPVELKTTGLKKsspks-ks 89  Streptococcus t...
PKU88837      31 IGKTLQEVDTQhvln------------gkrNKGYAGaIIEQSVLgYPADSDRRPDLlvdgTPVELKTTGLVTskkskang 98  Bifidobacterium...
CDB90893      38 LNKTLGEVDTNhvfdkt--------igkpkITGIAGdVIEQSVLgFPADNKQRPDLfvdgIDIELKTTGIRYtkk----g 105 Clostridium sp....
WP_118821621  19 VGKTLGEVDKNkvfgkt--------ignpkITGIAGdVVEQSVLgYPADSKSEPDLlvdgIPVELKTTGLKKvgkrd-ks 89  Neisseria menin...
PYS64110      27 LRVMADEYRIPvwkn------------gheNKGWAGlVIEHYLG-LPQNSRQEPDF----GDWELKVVPLRKea------ 83  Acidobacteria b...
CDH47031      18 LRPLADYYGLTvwkd------------gkkNKGWTGhVIERYLG-LPLNSSPAPNF----GSWELKVVPLKYdr------ 74  Candidatus Cont...
RUM60682      18 LRKLADELGITvfka------------gkkNKGWAGhVIERYLG-LPINSAQAPNF----GSWELKLISLKYlk------ 74  Persephonella sp.

Feature 1                                                                                        
P16667        75 ngKYSSKERLVLNIINYe--kVANENFETssFLSKNNTIELAFYEYIKGTpsd--------nwIIKEAVLYemhk----- 139 Staphylococcus ...
OIP83251      81 ngDIKVKEPTQIQMINYfe-vANESWETAk-IRKKITLTFWIVYLAKDNSkrln-----qddyRIIDYFLDhpn------ 147 Porphyromonadac...
OFX49284      81 dgQIKAKEPTQIQMINYfe-vANEKWETAk-VRKKINLTFWIVYLAKENSksl-------hqdDYKIVDYFidhp----- 146 Bacteroidetes b...
CAC27338      90 khALEAKEPMSITAVSVdkigSQDNFYESt-LWHKLEELLIVYYLYDSDK-------------IVKASEYSnfpiqgyqf 155 Streptococcus t...
PKU88837      99 dsGYKAKEPVSVTAVQLd--nICDEDFEHsgFWEKARHLLFVYYLYAHKTnspady-gdfpllGYQFVDFIg-------- 167 Bifidobacterium...
CDB90893     106 kkQYEAKEPMSITAVSPdk-iVYEEFENSn-FWHKLERMLLVYYHYSAEKtvnaa---dyanfYIKGYEFHefd------ 174 Clostridium sp....
WP_118821621  90 gyRLAAKEPMSITAVSLdkiaGQTDFYQSp-LWHKLREMLLVYYLYDSPTtvaaseyadfpiqGFHFYRFSp-------- 160 Neisseria menin...
PYS64110      84 ngTLRVKESMAITMLEPae-iLANKFEDSh-LYDKLRSMVVVSRVYESALeqhsi---lhaaaEFDLDNLK--------- 149 Acidobacteria b...
CDH47031      75 nrVLKVKETMAITMLDPve-vLAKDFEDSh-LFTKLRKQIVVSHIFEDVNets--------aiLHTAAEFDldn------ 138 Candidatus Cont...
RUM60682      75 sgELTVKETMAITMIDPyn-vLHTPFEESh-LLQKLKKMLIFARIWEGTNeprs------ilyGIYEFDLEnk------- 139 Persephonella sp.

Feature 1                                                                                        
P16667       140 ---npiDYEIIKQDWEIINQYi-----------nEGKAHELSEGLTSYLAPCTKGAnasslrn---qpysdiKAKQRAFS 202 Staphylococcus ...
OIP83251     148 ----etKISTFKDDWELIQKYi-----------iNGLADKLSCGMGTYIEPKTKGKnnqdktnapdgkggitRARRRAFY 212 Porphyromonadac...
OFX49284     147 ---sedKIVIFKKDWEEIQKFi-----------iNGLSDKLSCSMGTYLEPKTKGAnnldktdapdgnggkiRARRRAFY 212 Bacteroidetes b...
CAC27338     156 lifseeDKKVLENDWKIVRDFvrnvek--naldkSIEFPKISKLRTEMSYMDTAPK----------------YPHPPRFR 217 Streptococcus t...
PKU88837     168 -----eDKELLKHDWEIVRDFiiqinaehpedpeTQYPRISSELNRQRLSVIDTSPk---------------WPNKPRFR 227 Bifidobacterium...
CDB90893     175 ----ekDTMRLKNDWEIVRNFirelqd-nydepeKEYPRISSELRNKLVCIDTAPK----------------WPHPPRFR 233 Clostridium sp....
WP_118821621 161 -----eDRKIIENDWKIVRDFvanvin--nnldkETEYPKISKLRNQMAYLDTAPK----------------YPNNPRFR 217 Neisseria menin...
PYS64110     150 ------IHDQVVADYEAIRRQi-----------rARGIDSVTGDLGKLVQARTKGRg--------------hGSTSRAFY 198 Acidobacteria b...
CDH47031     139 ----phVYAQVKADYETVRAAl-----------qTSGFSSLTGKMGILVQPRTKGAg--------------hGSISRAFY 189 Candidatus Cont...
RUM60682     140 -----eLYEQIKEDYELVRNVi-----------kTKGFDALTGKMSVYIQPRTKGTg--------------hGSKTRAFY 189 Persephonella sp.

Feature 1          
P16667       203 LK 204 Staphylococcus aureus
OIP83251     213 YK 214 Porphyromonadaceae bacterium CG2_30_38_12
OFX49284     213 YK 214 Bacteroidetes bacterium GWA2_30_7
CAC27338     218 LT 219 Streptococcus thermophilus
PKU88837     228 LK 229 Bifidobacterium thermophilum
CDB90893     234 LK 235 Clostridium sp. CAG:253
WP_118821621 218 LK 219 Neisseria meningitidis
PYS64110     199 AR 200 Acidobacteria bacterium
CDH47031     190 AR 191 Candidatus Contendobacter odensis Run_B_J11
RUM60682     190 AR 191 Persephonella sp.

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