1W36


Conserved Protein Domain Family
RecB_C-like
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cd22352: RecB_C-like 
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C-terminal nuclease domain of exodeoxyribonuclease V subunit RecB and similar proteins
Exodeoxyribonuclease V subunit beta (RecB) is a helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair; it binds to DSBs and unwinds DNA via a rapid and highly processive ATP-dependent bidirectional helicase. The C-terminal PDDEXK nuclease domain belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411756
Aligned: 187 rows
Threshold Bit Score: 124.316
Created: 16-Jan-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative active
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1: putative active site [active site], 6 residue positions
Conserved feature residue pattern:H E D D [YW] KClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
1W36_B        901 WRVTSYSGLqqr---------------------ghgIAQDLMPRLDVDAAGvasvveep--------------------- 938  Escherichia coli
RTZ79756      821 FVLSSFSRMnrk---------------------keaLQDMEMESALVDATPveirteidlgmrrendetneiglps-tae 878  SAR324 cluste...
WP_115608357  942 WEVTSFSSLrgqvggegl----------ldeaaaevEKGDDARDDEVVFDPaf--------------------------- 984  Bradymonadales
ACY17368      940 FVVTSYSAMknaepalyaela---nadarrvlaqgdAVANDTADADADADTdsdsasaasdstaasaqapapmlfsdqss 1016 Haliangium oc...
WP_111332264  855 RQLTAFSSVkkhda------------------psadKTHEDEPDSPAAPAPdprfga----------------------- 893  Bradymonas se...
WP_084511779  948 LQLHSFTSLsrafg-----------------etpraASREEEARADEVPVPrqarp------------------------ 986  Geothrix ferm...
WP_111331094  921 PIVTSYSRIkntvgrlgphqgevpairveragkssfLEDDLVADGGEEAVAilap------------------------- 975  Bradymonas se...
AGA28702      896 YEVTSYSRMkr------------------------dWADDPAPIEADELQRevsrsgdag-------------------- 931  Singulisphaer...
PZM93386     1255 FVITSYSRM---------------------------RGFRGVEDEDEERIEgermvie---------------------- 1285 Proteobacteri...
WP_082342481  901 YRITSYTQLreg---------------------apkGGHEPERDEFAGESEraahpa----------------------- 936  Vulgatibacter...

Feature 1                                        #                                                
1W36_B        939 --------------tltphqfpRGASPGTFLHSLFEDLdftqpvdpnwvreklelggfesqwepv--------------- 989  Escherichia coli
RTZ79756      879 lhsvttervdgfqpetnkdplpGGVQTGNMLHELLELVdfntiqasnspqewlahpsvyrlldsfrerygrs----vetl 954  SAR324 cluste...
WP_115608357  985 ---------------------pGGMATGNFVHGVLETLeyarvrdyadeaawvadeelqaffeqhrssfgadpstlkpam 1043 Bradymonadales
ACY17368     1017 gigdagadesatgvraaedelpGGPQSGVFLHSVLEHLpfaslaeadgfddwcerpevasvfadlmlrhgrd-----pah 1091 Haliangium oc...
WP_111332264  894 ----------------dtpmpwGGTDYGSFLHNVLEDLsdy--------------------------------------- 918  Bradymonas se...
WP_084511779  987 -----------------agglpGGTATGTALHELLERIpvgrts------------------------------------ 1013 Geothrix ferm...
WP_111331094  976 ------------------delpGGKRAGVFLHELLEQAdlar-------------------------------------- 999  Bradymonas se...
AGA28702      932 --------------alaegdlpGGAVVGTFLHEIIESVsfdetaa----------------------------------- 962  Singulisphaer...
PZM93386     1286 ---------------pgqdelpGGTSTGIFLHDVLARVpfpevpadfd-------------------------------- 1318 Proteobacteri...
WP_082342481  937 -----------------ddelpGGAGSGIFLHELLEKVsprsvve----------------------------------- 964  Vulgatibacter...

Feature 1                                           #                                             
1W36_B        990 ----ltewitavlqaplnetgvslsqlsarNKQVEMEFYLPIse------------------------------------ 1029 Escherichia coli
RTZ79756      955 prvaeiiwstlrvpvklgksndaleladseRFIRETDFYFPIpfk----------------------------------- 999  SAR324 cluste...
WP_115608357 1044 ravyrtllsrvempvageealealhrlnpeRVRRELEFLFPIp------------------------------------- 1086 Bradymonadales
ACY17368     1092 lrysqrvvyqclstplrvgrkivpnlascsENLRELEFVYPIpqla---------------------------------- 1137 Haliangium oc...
WP_111332264  919 ---------------------------ssaLRCDDVDAWLALdevkyvfeqrsk-------------------------- 945  Bradymonas se...
WP_084511779 1014 ------------------------rlgpeaWRDALLPLAMEClkd----------------------------------- 1034 Geothrix ferm...
WP_111331094 1000 --------------------------arecAKLSEWMEDADVdatfrrtmrtygveeeylgfckklvwraiktplrldag 1053 Bradymonas se...
AGA28702      963 -----------------------agsldawRALATVASTIDLa------------------------------------- 982  Singulisphaer...
PZM93386     1319 ---------------------afcasetvgRIFAEAARAHGIadehlpha------------------------------ 1347 Proteobacteri...
WP_082342481  965 -----------------------agspeefLARTEVGEFFQReaaragvdrrhlrhagalvh-----------galagri 1010 Vulgatibacter...

Feature 1                                                                                         
1W36_B       1030 -----------plIASQLDTLIRQFDp-------------------------------------------------lSAG 1049 Escherichia coli
RTZ79756     1000 ----------vkgKMDKVQETQNYSWkvd----------------------------------------------pkVDG 1023 SAR324 cluste...
WP_115608357 1087 ------------eLCEEEADGLRRKF---------------------------------------------------GRG 1103 Bradymonadales
ACY17368     1138 ---------prssDSAAAAAAQASASat-----------------------------------------------tgRDP 1161 Haliangium oc...
WP_111332264  946 --adrigpeftpySARILFDTLRTPLalpgfdkpvaiaeipmtkia------------keidfhfpmpqenldfarwPDD 1011 Bradymonas se...
WP_084511779 1035 ----------qglNPALAGEALHLAWaaltteip------------------------------------lpegpamRLD 1068 Geothrix ferm...
WP_111331094 1054 qegaesaipcvaqSDKVLRELEFVYPip-----------------------------------------------erPSE 1086 Bradymonas se...
AGA28702      983 ------------mARHAIQPAYRANAeamvfraltvdvptgggptipgfcrcprsiremeflfpfpeeahprlsdpsPGK 1050 Singulisphaer...
PZM93386     1348 -----rrlvwaglTTPLVFEPLRLEGgvaradrw-----------------------------------rsemeflyPLP 1387 Proteobacteri...
WP_082342481 1011 rlrdgrilegiahAPRLLREAEFLYPipe---------------------------------------------rshPRL 1045 Vulgatibacter...

Feature 1                                   #                ###                                  
1W36_B       1050 CPPLEFmqv---------rgMLKGFIDLVFRhe----grYYLLDYKSNwlgedssaytqqaMAAAMqahrYDLQYQLYTL 1116 Escherichia coli
RTZ79756     1024 WKVEKG--------------FLRGSIDFLFEhk----glIYLLDWKSNllsdy----hvetLEQEVkq-hYELQLQIYTL 1080 SAR324 cluste...
WP_115608357 1104 ARVQGG--------------FVKGFVDLLFEhq----gkIYFADWKTNlvrsy----dsptLAGHVaa-nYAEQARLYTV 1160 Bradymonadales
ACY17368     1162 VRVERG--------------YIKGIIDLVFQfq----grAYLIDWKSDilasy----snraVARRVys-tYRLQAQLYAL 1218 Haliangium oc...
WP_111332264 1012 APTIERg-------------WIKGSIDLTFEhgvggdsrVFIADWKSNflkdy----rpeaVARSLdd-aYALQARIYTL 1073 Bradymonas se...
WP_084511779 1069 DVEQRLpevafqmpfpdhpdGLEGSLDLLFEwe----drIYILDWKTNsleggd--ygpeaLERTMaa-hYDLQVRIYTL 1141 Geothrix ferm...
WP_111331094 1087 QAVERG--------------FIKGFVDLIFEnd----skIYFADWKSDiltdy----gpqsLNQRVae-sYGIQATIYIL 1143 Bradymonas se...
AGA28702     1051 LVVERG--------------FIKGYVDLVVEha----glVYVVDWKSDvlpsy----daeaITAHVar-nYELQAKLYAM 1107 Singulisphaer...
PZM93386     1388 GERERG--------------FVKGFVDLVFEag----grVYFADWKSDclpsf----dtdyVRKYVqs-sYEIQLRLYAI 1444 Proteobacteri...
WP_082342481 1046 TQALTGqhle------irrgFVKGFVDVLFEhd----glAYFGDWKSDvlpsw----sraaIDERVek-sYRLQAQLYSL 1110 Vulgatibacter...

Feature 1                                                                                         
1W36_B       1117 ALHRYlrhriadydyehhFGGVIYLFLRgvdk------------------------------------------------ 1148 Escherichia coli
RTZ79756     1081 ATSYWfkldse-ekynekFGGVLYIFLRgmp------------------------------------------------- 1110 SAR324 cluste...
WP_115608357 1161 ALCRVldmtce-adyearFGGLFYFYVRgmhp------------------------------------------------ 1191 Bradymonadales
ACY17368     1219 ALVKMlgiese-sqhrrrFGGLLYCFVRgmstfa---------------------------------------------- 1251 Haliangium oc...
WP_111332264 1074 AMVRMlgitna-qdydarFGGCLYLMLRamspe----------------------------------------------- 1105 Bradymonas se...
WP_084511779 1142 AALAFagidhe-aafrerFGGAVYVFLRgl-------------------------------------------------- 1170 Geothrix ferm...
WP_111331094 1144 AMVKFleitdq-kayderFGGYFYLFVRgmgas----------------------------------------------- 1175 Bradymonas se...
AGA28702     1108 ALVKAlrirne-veyerrFGGMIYVFLRasrdaeclsrkvslhpemkdvgvprvpysdpvrprprhshmgseygtawhpe 1186 Singulisphaer...
PZM93386     1445 AIRKLfrlete-aefderFGGAFYFFLRgme------------------------------------------------- 1474 Proteobacteri...
WP_082342481 1111 ALVKMigvrde-asyearVGGFLYLFLRgmkpd----------------------------------------------- 1142 Vulgatibacter...

Feature 1                                               
1W36_B       1149 ---------------ehpqQGIYTTRPn--aGLIALMD 1169 Escherichia coli
RTZ79756     1111 -----------------qhKGVYFKRPs--wQDLKEYE 1129 SAR324 cluster bacterium
WP_115608357 1192 ---------------qrpgEGIYRARPs--wAQIVGFE 1212 Bradymonadales
ACY17368     1252 -------------ddegrlPGVYYARPr--lDDIAAFE 1274 Haliangium ochraceum DSM 14365
WP_111332264 1106 ---------------qpsgYGVAICRPt--wAQLCAWD 1126 Bradymonas sediminis
WP_084511779 1171 -----------------ptGGLWTHRPs--wAEVQAWR 1189 Geothrix fermentans
WP_111331094 1176 ---------------enpaAGVYYRRPt--wEDILQDE 1196 Bradymonas sediminis
AGA28702     1187 dpqklqcdspsgtdsepagQGLYFSRPawseVLLDEAD 1224 Singulisphaera acidiphila DSM 18658
PZM93386     1475 -----------------rgAGIYFERPs--fAELLRWE 1493 Proteobacteria bacterium
WP_082342481 1143 ---------------gdgtEGVHFERPs--wSHILEWE 1163 Vulgatibacter incomptus

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