Conserved Protein Domain Family
PDDEXK_nuclease
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cd22348: PDDEXK_nuclease 
uncharacterized PDDEXK nuclease may function as a restriction endonuclease
This family belongs to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411752
Aligned: 7 rows
Threshold Bit Score: 352.52
Created: 29-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative active
Feature 1: putative active site [active site], 3 residue positions
Conserved feature residue pattern:[DN] [EDQNH] [KH]Click to see conserved feature residue pattern help
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                       #    # #                                         
RLG30859      18 GYIKTHRAGNTGIGKTLEDLLEIEENNIPGPNATMIELKSARKNAKSMLTLFTKSPlppk---ansaLLERFGYESArgn 94  Methanosarcinal...
SIM79489      17 QWIHSNRTHDTGIGKTLEDLLGIQENNFPGPNGEKVELKSIRKDSSSMITLFTKSPkpge---siknLLDDYGYQSVndp 93  Cuniculiplasma ...
RNJ74361      12 GYYKTIRSGNTGVGATLEHLLQIPENNIAGPNGHQTELKSRRKTSSGMMTLFTKSPdppk---intkLLKYYGYPDDkqp 88  Thaumarchaeota ...
PSP66188      21 GYVETHRAGNTGIGKTLEDLLGIEENNIPGPDAAGVELKSARRNSGSMMTLFTKEPprgsrelwassLVEKYGYEDDd-- 98  Halobacteriales...
WP_059057846  20 GFIETHRAGNTGIGKTLEDLLGIEENNIPGPDAAGIELKSTRRQSNNLTTLFTKEPprdqrelwnqdLVRELGYVDSk-- 97  Halobacterium h...
OPY37068      18 GYVKTHRVKDTGIGKTLEDLIGIQENNFPSSNGHKIELKSGRKDKTSMVSLFTKSPlprg---sntkILQEYGYLSDn-- 92  Methanoregula s...
WP_148690059  17 QWIHSNRTHDTGIGKTLEDLLGIQENNFPGPNGEKVELKSIRKDSSSMITLFTKSPkpge---siknLLDDYGYQSVndp 93  Cuniculiplasma ...

Feature 1                                                                                        
RLG30859      95 KRKELHTTVNAMVFNTLkgkpGFKIDIQKDRINLIt---AEDEIVGYWDKETLRNSFERKLPKLLYVKAe-tRGKGSDEE 170 Methanosarcinal...
SIM79489      94 TKKNLHVDLYGNRTTEIkgipSLKLAVTPDRIDIVn---IHGKIYGGWDYETLKKSFELKMYRVLLVKAd-kRGSKMNEE 169 Cuniculiplasma ...
RNJ74361      89 NKTVLHTTVYTKKFNTIqgkeSFKINSLSDKIEIVhknpIASLPVPYWTKESLENAFLKKYPLWLLYVIadsRGRGEDEE 168 Thaumarchaeota ...
PSP66188      99 GRPALKITLHVDEFNNQ----GFRTVTDEDGVHIEh---EDDGIVATYLLDYLRDTYEEKFPEMVLVEAd-tQTIDGDEY 170 Halobacteriales...
WP_059057846  98 DRQALKVTIGTGESNNR----GFYLDYDDNSVSVVh---DDYGICATYPLSLLRDVFERKLPELILVIAd-vEKRDGREY 169 Halobacterium h...
OPY37068      93 GRNKLEVNLSSKTFNLIkgtpRIKTNVTETGIELVd---THGKVSGSWPNEILKRFIERKLPEVLYVKAn-sKGSGENEM 168 Methanoregula s...
WP_148690059  94 TKKNLHVDLYGNRTTEIkgipSLKLAVTPDRIDIVn---IHGKIYGGWDYETLKKSFELKMYRVLLVKAd-kRGSKMNEE 169 Cuniculiplasma ...

Feature 1                                                                             
RLG30859     171 FWFNEAWLLSGFNFDSFVRLLREGIILVDIRIGQYPDGRPHDHGTGFR-----VLPDKLDLCFSNRKRI 234 Methanosarcinales archaeon
SIM79489     170 FNYNEAWVLMGFSFERFITLISNGIVKVELRLGIYPKGSKNEGKPHDHgtafrVLEGNIQDCFAYRDRI 238 Cuniculiplasma divulgatum
RNJ74361     169 FWFNEAYQLSGFSFKNFLRLLETKTIYVDIRIGVYPDGRSHDHGTGFR-----IRHDNLDQCFSTRERV 232 Thaumarchaeota archaeon S15
PSP66188     171 FWYNEGYYLEGFDGEEFLSLIRESIIKIDLRMHLRDSGGARNHGTAFRi----KDTSKLDRAFETRSQL 235 Halobacteriales archaeon Q...
WP_059057846 170 FHYNEAYHLDGFDGDDFLGLMRDGVITLDLRMHIKDNGNIRNRGTAWRi----MDESRLDEAFEERTPL 234 Halobacterium hubeiense
OPY37068     169 FWYNEAWVLSGLDFDTFLRMVSEDNIIVNIRIGQYPNGKTHDHGTGFR-----VLPSKLELCFKNRRRV 232 Methanoregula sp. PtaU1.Bi...
WP_148690059 170 FNYNEAWVLMGFSFERFITLISNGIVKVELRLGIYPKGSKNEGKPHDHgtafrVLEGNIQDCFAYRDRI 238 Cuniculiplasma divulgatum

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