Conserved Protein Domain Family
PDDEXK_nuclease

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cd22347: PDDEXK_nuclease 
uncharacterized PDDEXK nuclease may function as a restriction endonuclease
This family belongs to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Statistics
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PSSM-Id: 411751
Aligned: 55 rows
Threshold Bit Score: 178.571
Created: 24-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
putative active
Feature 1: putative active site [active site], 3 residue positions
Conserved feature residue pattern:[D] [EDQNH] [KH]Click to see conserved feature residue pattern help
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                      #    # #                          
WP_101885168 158 EELLNKLHIIHNRGFIPSit--pGDPGVGDTLEHALGIERNNSKAPDYKGIELKTTrlirnggnrtTTRSTLFTRVPDEG 235 [Ruminococcus] ...
WP_028284024   5 TKIEKEFNRIKNLGFIPSrr--kNNTGIGKTFEDYLGVTENNDKLPDFDGFEVKSQra------ltSSFLTLFTKSPTGP 76  Olleya marilimosa
WP_065232890   6 ELFIRDFNKVRDLGFVPSrr--sNSTGIGKTFEDLIGVIENNAKEPDLHGFEIKSHrn------lsESYITLFTKSPTIP 77  Gallibacterium ...
WP_102550815   8 ESFSNDFLRVKKLGFRPShr--aNSTGIGKTYEDLLGVAENNLKEPDLHGFEVKSQra------ytGSYVTIFTKSPTMP 79  Vibrio splendidus
WP_048836969   6 SRFKEDFLKVKDLGFVRSsr--tNSTGVGKTFEDFVGVAENNLKEPDLHGFEVKAQrs------ysGSYVTLCTKSPTHP 77  Acetobacter orl...
RKW17556       5 EELKKEFLRIKAQGFVLNtrpnnKDGGIGNTFEDLLGIKENNLSEADFRGVEIKSQrl------fnSSFISLFTKAPSYP 78  Capnocytophaga sp.
WP_121698552   2 LLISGAPPEESSLPDNYDs---nEYILLCQRLEDYIGVVENNIDEPDLFGYEIKAHrn------svGSYITLFTKSPDFP 72  bacterium J10(2...
OGU14251       4 RKIKKEFKRVKSLGFIKSkr--rNNTGVVKTFEYYFGLNENNIKDPYYEGYVIKSQsf------lsSSKIILFTKSPTHP 75  Ignavibacteria ...
WP_057327993   5 DFIISKFKEVKSLEYVPSnr--aNNTGIGKTFEDYIGVVENNLDEPDLAGFEIKSHrg------tsCSYVTLFTKSPSFP 76  Parabacteroides...
WP_023983497   6 QQIIERFKQVKALGFIKSnr--kNNTGIGKTFEDYIGVLENNIDEPDLFGYEIKSHre------etASYITLFTKSPNFP 77  Prevotella
Feature 1                                                                                        
WP_101885168 236 Ms-YRQIVDAYGKVQVprgstearlqMYETLMCARVNAYDLILevdvnndkln-------imhqeervrkYVSAWYLENL 307 [Ruminococcus] ...
WP_028284024  77 NkaNTYLRDKYGEEYEeypg---lkkLHTSIFSNKFNTYKSRTgfiivndkadsvvrlevkdlvtgaitdDSVYWSYEDL 153 Olleya marilimosa
WP_065232890  78 KgaNTYLRENYGSCDKehpe---ikvLHTSIFHGKFNTHIAGAkfsleidwpdkkl--yivveknngeldKSVYYSFDSL 152 Gallibacterium ...
WP_102550815  80 KgaNAILRNNYGSFDEkypd---lkvLHTSIFADKFNTHKSGYrftlsidnyerki-ylivadkdektidNSTYWTFDAL 155 Vibrio splendidus
WP_048836969  78 IkaNQYIKDKYGYPDQshpn---ikvIHTSIFHNKFSINSYSGvkfrlqvdllekrvyvlvfnlneevidSSIYYSFESI 154 Acetobacter orl...
RKW17556      79 KkaNNYLRETYGEIRKeehs--dkkvLYCSIFGNREATVYEKYkiklqidktkkhi-tliikdlqdnllsNEVYWDFSTL 155 Capnocytophaga sp.
WP_121698552  73 KgaNSILKDRYGVPYDdipe---lkkLHTSMFADRGNTFNNRLsfrlindrenkvlkigifdlgtgrlidSSTGYTYNCL 149 bacterium J10(2...
OGU14251      76 EkaNQYLSEKYGLFDKkfkn---vktILTTLYCNKFNTYLDTFsfkldidktrkklyfivknlsdnkivkEDIYYTFDDI 152 Ignavibacteria ...
WP_057327993  77 KraNAYLKDKFGTPYEdaps---insLHTSMFANSYNTYMKKYsfkllnnpvaktiligvfdlntkelldCSVGYTYQDI 153 Parabacteroides...
WP_023983497  78 RkaNSYLRDKYGMPYEdntd---lkkLHTSMFASKYNSFGNVFsfrlindrnrkavkigiydldtkrlidDTVGYRYDCL 154 Prevotella
Feature 1                                                                     
WP_101885168 308 RkaLLLKHHETFWVka-qsETRGGIEFFRYDKVLHTKNPNAs-lLAPLFEANKITVDLAAH 366 [Ruminococcus] gnavus
WP_028284024 154 SkaLQKKLQALFYVna-etRKVNGIEEFHYTQADIYLNPSLa-nLLKLIDDGKLMIDIRIG 212 Olleya marilimosa
WP_065232890 153 Qk-ALTKLQNLAFVsa-dtKKDNGIEKFHFNKATIFSEFRGlefFLNMLEEGLIMYDVRIG 211 Gallibacterium anatis
WP_102550815 156 EqaIVAKITRLAYVsaetrRNAMGQEEFWFNKAHIFSGLKPfhtFLELLMEGVIMFDIRIG 216 Vibrio splendidus
WP_048836969 155 Dn-ALRKIKNLAYVsa-qtEKRNFEEFFHFTNAILFSEMKGldhFLQEIINGNIMYDVRIG 213 Acetobacter orleanensis
RKW17556     156 Qk-ASKKLDKLFLVfa-dtKKIDNRPHCHFIEGRIYYGFNFe-kFLTELELGSIMFDIRIG 213 Capnocytophaga sp.
WP_121698552 150 NkiLHKKLIDLFYVsa-erKYVDDKEFFHFNQATIYSKPSLe-rFLSLVDKGLIMYDIRIG 208 bacterium J10(2018)
OGU14251     153 Ie-NTKKLDKLLVVta-ktKINRGNQYFYYQNATLYFGFKLe-kFLNLFKRGRIKCRIRIG 210 Ignavibacteria bacterium GWA2_35_8
WP_057327993 154 QkaLTKKLKNLLYVta-qtKKEGGKELFYFNKADIYTEPSFe-rFISLLTDGKIMYDIRIG 212 Parabacteroides distasonis
WP_023983497 155 DkiLNRKLKNLFYVsa-erQTENGDEYFFFNKAEIYSHPTLe-kFLTLIDDGLIMFDIRIG 213 Prevotella

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