Conserved Protein Domain Family
PDDEXK_nuclease
?
cd22345: PDDEXK_nuclease 
uncharacterized PDDEXK nuclease may function as a restriction endonuclease
This family belongs to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
?
Statistics
?
PSSM-Id: 411749
Aligned: 65 rows
Threshold Bit Score: 158.141
Created: 2-Jul-2020
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Download Cn3D
Conserved Features/SitesClick to see Conserved Features Help
 
putative active
Feature 1: putative active site [active site], 3 residue positions
Conserved feature residue pattern:[D] [EDQNH] [KH]Click to see conserved feature residue pattern help
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                              #         
PKO61947      34 LLKRKNPYLFKAKAVqs----aPDLVKRLLDAYLSSKEETIFGdFLESLAIHVCGQAygg--kksNAEGIDLEFd----- 102 Betaproteobacte...
RJQ42878     124 DNFDINPLLAKALTLdt----pRKVIAFNVYQTVTRSVVTSWGnAVESLAKYSGCKDndvaiegqTGTNFDLIKt----- 194 Gaiellales bact...
RAM48159      40 KKLNPNPFLIRALNLdt----pNEVVRLNVYMAATRSIVTSMGfFIEDLLLTSSDTVek----apKKSGWDLIKtt---- 107 Hapalosiphonace...
PWH14121      32 EDLHINPFLIRILAGemgwddaRPIVTWLVSQRLERGTVTAFGlALQEAAKVFSEGS--------GVEGADIMKt----- 98  Ardenticatenia ...
TMK73195      75 ADLTFNVVLLRANATmlelcdaETLLRYRLAQHVERGSVTAFGtTLQTISKDIAGHAt-------GVAGADIMLv----- 142 Actinobacteria ...
RLG28864      36 INPFLIRILSHELGLdn----sEAIVRWLISQRLERGTVTSFGiTLQNAAKVFSEGT--------GVEGADILKt----- 98  Methanosarcinal...
TET90693      30 ENLDLNPFLLRLLGLnt----pREIAEFMVSQRTERGVVTSYGiRIQTIAKVFATGT--------GAEGADIMKe----- 92  Methanomassilii...
WP_099629362  67 DDLTPNPLLMRLVGTaaelnsaEALVEYMINARLERSTSTGFGmTIQKVATAFCETT--------GVGGADISImkndes 138 Sporosarcina sp...
OGW14851      30 KNLNFNPFLLRILNLds----pEKIAEFMINERLERSVVTSFGsRIQKIAKLIGGKGt-------GVEGGDIFIe----- 93  Nitrospirae bac...
WP_115792950 217 EELSFNPFLLRLLGLkt----pNEIAEFMVAERVERSLVTSYGtHIQRIAQIVAGRGt-------GVEGADVCKe----- 280 Ammonifex thiop...

Feature 1                # #                                                                     
PKO61947     103 rDSRRYIVSIKSGPNwg---nsQQIKRMIANFNqarkiagvkvsveAVNGCCYGKEanph-----------kgsYIKRCG 168 Betaproteobacte...
RJQ42878     195 iGGTDYYIQVKSGPNtm----nVGMVTSLNNAIarieqq--rpnaqGILGMTYGTRdrisnqit---anlndadTKMKIG 265 Gaiellales bact...
RAM48159     108 sDGEKFWLQIKSGPNnm---dkDQVVYWSEKIQeklk-----egykAYIGFTYGKItsktvtigllkqilpdweIQTLIG 179 Hapalosiphonace...
PWH14121      99 rSGCHYYIQVKSGPNtipkdmgIRISQLLRSAQrrnr------gsiALFGMCYGNKhqvssivr--kyveqeggVEWLAG 170 Ardenticatenia ...
TMK73195     143 rNNRRYYIQVKSGPHtanrdiaQNIGALLNSARardp------davCMFGVCYARPdqisaivk---gqlqragVGLRVG 213 Actinobacteria ...
RLG28864      99 kEGRHHHIQVKSGPNtipkdlgVRIAQLLRSAQrrnr------gsvALYGMCYGSKaqvssivr--ryvqeeggVDWISG 170 Methanosarcinal...
TET90693      93 kNGKRHYIQMKAGPNtpnkdlvAMINRLLRGAVrrnr------gsvPLLGMTYGKRkrvssi------iqryseVDWLIG 160 Methanomassilii...
WP_099629362 139 gNAIRWYIQMKSGPNtvnkdicIQISSELQSAVrrap------gsaGMLGITYGKFdrvsgi------tqkylsFDFKAG 206 Sporosarcina sp...
OGW14851      94 rTGKRYYIQMKAGPNtpnkdlvRMINQLLLSATrrna------gsiALLGMTYGKRekvsni------irgysqVDWKIG 161 Nitrospirae bac...
WP_115792950 281 eGGRRYYIQVKAGPYtvnkdisKQVSDLLTSATrrns------gsaALLGMTYGSKekvssi------vrrysrVDWLVG 348 Ammonifex thiop...

Feature 1                                                                                  
PKO61947     169 QDFWELVSGVddFYQQIVEPLGFDAkrrteefd-------ekyaavinQFSAAFICDYCep----dGVINWNKL 231 Betaproteobacteria ba...
RJQ42878     266 REFWDFISERedYHKTLFELLEASSa---------------------gILSESFIDLIEski--veLEEQWEAR 316 Gaiellales bacterium
RAM48159     180 KDLWNFLSEDpdYSSKLFEVLRESAqqv-----------------lhqKSLSEEIDSCAdrvtdegSIPNVQKN 236 Hapalosiphonaceae cya...
PWH14121     171 REFWEFISGDqdCIDEIYKIAGEVGeefrdakght---lseiledkiqDLLEQFRSLYGs-----nGDEMWHNL 236 Ardenticatenia bacterium
TMK73195     214 REFWEFISGDaeCLNELLGLAGEAAgeappgeasfaerveqkldslvaEFSGRYGRTLDdq----aWAFFLADN 283 Actinobacteria bacterium
RLG28864     171 KEFWEFISDDpqCLDEIYEIAAEVGrtfkdpkges---lseviekkivELNKEFEKKYGr-----sGKTMWEKL 236 Methanosarcinales arc...
TET90693     161 REFWTFISDDdeFAKELFKLIVDVAddvadahkekt--ysqrfqekvdEVAEEIKKKYGd-----gGEEMWQKL 227 Methanomassiliicoccal...
WP_099629362 207 RDFWEFISNDsdCYKKLWYLTNDIAdnfedkgglt---lkeliemkknELTSQFIEKYGe-----yGEEMWNNF 272 Sporosarcina sp. P21c
OGW14851     162 REFWEFIGYRg-IAQEIYEIIGEVNkefkeegktf----sqlydekldELQEAIRKKYGe------EEKLWERL 224 Nitrospirae bacterium...
WP_115792950 349 REFWGFISGDpdYASKLFKLAAEVAaevqrekg-------pfpirekvREIAGRIREEYg-----kGRQMWEKL 410 Ammonifex thiophilus

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap