4XQK


Conserved Protein Domain Family
LlaBIII_nuclease-like
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cd22333: LlaBIII_nuclease-like 
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nuclease domain of type ISB restriction-modification enzyme LlaBIII and similar nuclease domains
This N-terminal nuclease domain belongs to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411737
Aligned: 63 rows
Threshold Bit Score: 183.892
Created: 25-Jun-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 4 residue positions
Conserved feature residue pattern:[EH] [D] [EDQNH] [KH]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                #                                       #              # 
4XQK_A         15 FDDLINQINTVsndvQRERGTLFEKLTLAYLKNEPTYKalYQNVWLLSEVPESygipKKDTGVDLVAEQkn-gDLVAIQA 93   Lactococcus l...
ABK77641       12 FDDVLDYIDKTsk-sTTVKGAKFEKLTREFLLKDRQFAkrFKEVHMWNKWPDRk--dDRLTGIDLMAVEhn-gEWCAIQC 87   Cenarchaeum s...
WP_084449849    5 LEDLLDKIWFGaq-nTVEKGSSFEHLIASYLRTAPEFAdrFEDVYLWQDWPERg--gQADHGIDIVAKDihtgGWCAVQA 81   Janibacter in...
WP_101630541   10 FGALFDRLYFGgl-dEQDKGSKFERLMRAYFLTDPLYAkdFAKVWLWEEYPDRn--gRADIGVDLVAERrd-gTRVAIQT 85   Pseudoglutami...
SMX95010       39 FGNLLDTLYYGsl-dERDKGTKFERLIRSYLMTDPAYAsqFDEVWEWSDYPGKa--gRTDDGVDLVARDaitgDLTAIQC 115  Brevibacteriu...
WP_102735908    5 FRQILASIREAsi-tEKDKGTRFELLVKRYLETDPVYRdrFSQVWMWMDWPYRn--gKIDQGIDLVAREavsgEYCAIQC 81   Akkermansia m...
WP_081582486   26 FRQLLEEFEGAak-sQAAKGRRFEEFCEAYFQTDPVWAerFDAVWSWMDWPGRa--gAADTGIDLVARErgtgDLVAIQC 102  Candidatus Mi...
RJN32549       17 LGHLLETYYREsn-dYRDRGDKFERLVRSYLTTDPAWAfqFSDVWLWQDYPDRg--tRTDTGVDLVAKDkftgELTAIQC 93   Nesterenkonia...
WP_096162814   10 FGRLLDSLYYGal-dERDKGDKFERLMRSYLMTDPAWTsqFSHVWLWSDYPDRn--gRPDTGIDLVAEEvt-gARVAVQC 85   Brevibacteriu...
KHE75603        6 FGELLDKLYYGal-dTRDRGDKFERLMRSYLLTDRAYS--FSKVWLWNEYPERg--nRSDIGVDLVGVRadtgEKVAIQC 80   Kocuria marina

Feature 1         #                                                                               
4XQK_A         94 KFYTNk----VGKSEINSFVAELGKS--------YYQRGLIVSTmd-dWNSNARETidq-----neKGIEIIGl----SD 151  Lactococcus l...
ABK77641       88 KFYDKdksstVDDSDVSKFLSKATSLekk---hkRTVNTLFAYTth-rITREAESKlkyhkcylmgRDVFRSSs----ID 159  Cenarchaeum s...
WP_084449849   82 KFYDPqs--hINKTDIDTFLSAASNK--------AFTSKLFVSTtt-sWGPTAKHVld-------aAEVTRIGl----SD 139  Janibacter in...
WP_101630541   86 KFYDPah--lIAKADIDSFIAASATR--------EFGERMLVSTslkgFGRNALTTiea-----ldRPFTHLGv----TQ 146  Pseudoglutami...
SMX95010      116 KFIDPqt--tVGKGQVDSFISASSTG--------EFSRRIFVSTtt-kMNATIESYmqr-----ldPPLTHLNv----FH 175  Brevibacteriu...
WP_102735908   82 KCYDEnh--lLALPDVGTFFASLHMQwptdlgrlPFASGMIVATtd-kWNLPLSETida-----qsIPCSRISl----SD 149  Akkermansia m...
WP_081582486  103 KFYAPta--sLSWPNVATFVGMLGRP--------EFTSGMIVSTag-aESPKVEVNldsh--akdtTMWRVADfeesaLD 169  Candidatus Mi...
RJN32549       94 KFLDPen--tVSKGDIDSFISASPKP--------EFSTRLLAHTa--eIGPTAQKTlqs-----qdPPVRVLDp----HQ 152  Nesterenkonia...
WP_096162814   86 KFYDPeh--vVGKKDIDSFIAASSTQ--------EFSRRLLVSTslkeWGTNAEAQiqe-----lsPPLTRIGl----AD 146  Brevibacteriu...
KHE75603       81 KFKDPdk--vIPKGDVDSFISASATA--------EFGERLMVSTsrkeLGGNARKTien-----ldKPWSTVGl----DQ 141  Kocuria marina

Feature 1                      
4XQK_A        152 LRNSQIDWSQFNF 164  Lactococcus lactis subsp. cremoris
ABK77641      160 WSMYPKWHVKPVK 172  Cenarchaeum symbiosum A
WP_084449849  140 LLESKVDWESIDW 152  Janibacter indicus
WP_101630541  147 LEQAPIDWSQFSL 159  Pseudoglutamicibacter albus
SMX95010      176 LANAPIDWAQFSL 188  Brevibacterium sp. Mu109
WP_102735908  150 LENSPIDWAACAK 162  Akkermansia muciniphila
WP_081582486  170 WNSFRIEKPAELA 182  Candidatus Microthrix parvicella
RJN32549      153 MDRADIRWAEFQV 165  Nesterenkonia sp. M8
WP_096162814  147 LADAPIDWSQFSL 159  Brevibacterium aurantiacum
KHE75603      142 LANAPIDWSQFNL 154  Kocuria marina

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