4XJX


Conserved Protein Domain Family
HsdR_N
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cd22332: HsdR_N 
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N-terminal domain of HsdR motor subunit of type I restriction-modification enzyme EcoR124I and similar systems
The N-terminal endonuclease-like domain of HsdR motor subunit of type I restriction-modification enzyme EcoR124I belongs to a wider superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411736
Aligned: 232 rows
Threshold Bit Score: 65.7525
Created: 19-Feb-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: ATP binding site [chemical binding site], 2 residue positions
Conserved feature residue pattern:[KR] [FYRK]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
4XJX_A         32 SESDLERELIQDLRNQg-----------------YEFISvk----------------------------sQSAMLANVRE 66   Escherichia coli
WP_090009892    9 SEKTFQENFVKKLENYkw--------------kaPDFLNgnik------------------------kvtVNTLIDNWRR 50   Clostridium s...
KWZ80745       19 AEKTFQENFVKELQKYkw--------------eaPEFLNgnkq------------------------kvtVADLVSHWRS 60   Bacillus coag...
KES17173        9 SEKVFQEKFVRELEKNkw--------------haPDYLDgskq------------------------kvtVNDLINHWRQ 50   Gilliamella a...
WP_100139171    9 AEKIFQENFVKELEKYkwqapd-------fldgnRRKVT-------------------------------VNDLITHWRG 50   Snodgrassella...
WP_127135589    9 SERVFQENFVKRMEQYkw--------------eaPEELNgnkr------------------------rvtVDDLINNWRQ 50   Veillonella s...
EDS74750        7 LEALIEQKLIDQLVYGes---------------qWTYRKdl---------------------------ktEEDLWKNFKY 44   [Clostridium]...
VEU71532        6 SEKEFEQAIVDRLTSPkngwq--------gfrdeSGYKNgysvi---------------------lenvtEEILVKNWKD 56   Mycoplasma ov...
WP_027120993    7 NERSFADAFIDYLIEHgwsgfaetafqntndiktYNQTHkvvl-----------------------knvtEKDLIQNWQS 63   Mycoplasma le...
AEC45618        8 NEAKFEEKLISLLKHYg-----------------WENRDitlkqisdpfnnselndvlkkysdnvlkrkdEQSLIENWKE 70   Mycoplasma hy...

Feature 1                                                                                         
4XJX_A         67 QLQNLNg-----vVFNDSEWRRFTEQYLDNps----------------------------dGILDKTRKIHIDYicdfif 113  Escherichia coli
WP_090009892   51 ELNRINadqlegvELTDNEFKQVILKVNKIsnsye---------------------aakilSMEDSVGKIDGIYrednpk 109  Clostridium s...
KWZ80745       61 ELNRINadqlegvELTDNEFKQVMAKVNQIsnsyeaa------------------kilaieGSKGKIDGIYRDDnpkitr 122  Bacillus coag...
KES17173       51 ELNRLNadqlegiELSDNEFKQVLAKVQQInnsyeaa-----------------kilameeSKGKIDGIYRDDHpniirk 113  Gilliamella a...
WP_100139171   51 ELNRLNadqlegvELTDNEFSQVMAKVNQLdnsyqaa------------------kllameESKGKIDGIYRDDnplitr 112  Snodgrassella...
WP_127135589   51 ELNRLNadklegvPLTDNEFKQVMTRVNQIsnsfeaa------------------kllsaeAGKGKIDGIIRDAsdrpgt 112  Veillonella s...
EDS74750       45 ILEQNNkdrlngeGLSDAEFDQVKNQLQFSsfykagewlvg----------engkvmvhvqRNTEKLHLVVMNHehia-- 112  [Clostridium]...
VEU71532       57 ILFHNNkdvlnnvSLSNEEMEQVIEKIDNCp------------------------------NFVETNILLTNEYisikrs 106  Mycoplasma ov...
WP_027120993   64 ILFHNNkdvlnhlPLTDTEMEQIITKINQMssis-----------------------lineTLIGGYIEIQRDNpqdver 120  Mycoplasma le...
AEC45618       71 IIYFRNrgelksiPLSDSEMEQILDKVNKRntvglknqfiingevsitrdagtpetnpdygKTKYLNIFSKTDVnq---- 146  Mycoplasma hy...

Feature 1                                                                                         
4XJX_A        114 dderle---------niylidkknlmrNKVQIIQQFeqag-------shanRYDVTILVNGLPLVQIHLKkrgVAIREAF 177  Escherichia coli
WP_090009892  110 itrkqit-------ltifkkaevrggdSSYQIAREVvtd---------kdnRFDIVLLINGLPLINIEQKrtdKSLDEAY 173  Clostridium s...
KWZ80745      123 kqitlt----------ifkkaevrggdSSYRIAREVqtp---------nhnRFDIVLLINGLPLINIEQKrtdKTLDEAF 183  Bacillus coag...
KES17173      114 qitlt-----------ifkkaevrggdSSYHIAREVqtp---------ngnRFDIVLLINGLPLINIEQKrsdKNLDEAF 173  Gilliamella a...
WP_100139171  113 kqitlt----------ifkkaevrggdSSYRIAREVqtp---------ngnRFDLVLLINGLPLINIEQKrtdKNLDEAF 173  Snodgrassella...
WP_127135589  113 hkitlt----------ifkkeevsggdSSYKIAREVwght--------edhRFDIVLLINGLPLINIEQKrsdQSIEEAF 174  Veillonella s...
EDS74750      113 ------------------------ggsSVYEVINQYraldtdgsniperdrRFDVTLMINGLPMIHIELKnkqHSYMDGF 168  [Clostridium]...
VEU71532      107 npaldpekigqevqlkifskkdigignNIYQIARQVtfktt-----kndekRADLMLLFNGMPLIHIELKnqsEKIQSAI 181  Mycoplasma ov...
WP_027120993  121 ygkkvll--------nifnrhdvgagkSVYQIANEVelpnd-----vlkkrRADIMLLINGIPLIHIELKnsnHAASEAI 187  Mycoplasma le...
AEC45618      147 -------------------------gkTIYQIAQQVvdkr--------ankRFDIVLLINGIPVIQIELKgknNYAIDAL 193  Mycoplasma hy...

Feature 1                                                      #    #                             
4XJX_A        178 NQIHRYSKEsfnseNSLFKYLQLFVISngtDTRYFANTtk---rdKNSFDFTMNWAks-------dnTLIKDLKDFTATC 247  Escherichia coli
WP_090009892  174 NQFIRYYKDge-ycNNFMAFSQMMVITteiETRYFATPks---ikDFNRVFTFHWAdk-------nnKPINDWNKVIEHF 242  Clostridium s...
KWZ80745      184 GQFKRYYRDge-ysHNFMAFSQMMVITseiDTRYFATPkt---ieDFNPSFVFHWAdk-------dnNVINDWKKVIEQF 252  Bacillus coag...
KES17173      174 EQFKRYYRDge-ycNNFMAFSQMMVIPseiETRYFATPkt---itDFNPKFVFHWAde-------fnKPINHWQKVAEQF 242  Gilliamella a...
WP_100139171  174 EQFKRYYREge-ysHNFMAFSQMMVISseiETRYFATPks---isDFNPSFVFHWAnk-------fnKPINHWQQVIEHF 242  Snodgrassella...
WP_127135589  175 YQFQRYYAKne-fvNNFMAFSQMMIVMsevNTQYFATPks---vdAFNLSFLFNWSydgksaygkcnEKMTSWEDIVDNF 250  Veillonella s...
EDS74750      169 WQIKKYIGEgk--fTGIFSAVQMFVISngvDTKYFSAAsd----tELNPKFISGWLds-------dnNPVCDYLDFARCV 235  [Clostridium]...
VEU71532      182 TQIKNYAKSgf--yKRIFKLVQIVVAMkpnEMLYLPNTnd---ieNINDKNFLKWTdk-------nnRAINDYLELIDKF 249  Mycoplasma ov...
WP_027120993  188 QQISTYHKNnc--yKGIFAMVQMLVALkpeKMLYMPNTknnakikESSFVEWFDFQn----------QQIKDWRKIVNNF 255  Mycoplasma le...
AEC45618      194 GQIRSYHKAgv-ykQGIFSLIQMFVAMd--ENEMFYTSnknnaddIVNKDFIFKWTde-------knEKITYWKDIVQSF 263  Mycoplasma hy...

Feature 1                     
4XJX_A        248 FqKHTLLNVLVN 259  Escherichia coli
WP_090009892  243 LmIPMAHQMVGD 254  Clostridium sp. DSM 8431
KWZ80745      253 LmIPMAHQMVGD 264  Bacillus coagulans
KES17173      243 LvIPMAHQMVGD 254  Gilliamella apicola SCGC AB-598-I20
WP_100139171  243 LmIPMAHQMVGD 254  Snodgrassella alvi
WP_127135589  251 LmIPMAHQMVGD 262  Veillonella sp. 3913
EDS74750      236 LrIPEAHEMIAR 247  [Clostridium] spiroforme DSM 1552
VEU71532      250 FsIPMAHKMIGD 261  Mycoplasma ovipneumoniae
WP_027120993  256 FcIPTVHRIIAD 267  Mycoplasma leonicaptivi
AEC45618      264 LnIPTSHNLVGI 275  Mycoplasma hyorhinis MCLD

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