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Restriction endonuclease HinP1I and similar endonucleases HinP1I is a type II restriction endonuclease that recognizes and cleaves a palindromic tetranucleotide sequence (G|CGC) in double-stranded DNA, producing 2 nt 5' overhanging ends, it belongs to the PDDEXK superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",