4RI9


Conserved Protein Domain Family
FAN1-like
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cd22326: FAN1-like 
repair nuclease FAN1
This model characterizes a set of nucleases that resemble Holliday-junction resolving enzymes. They belong to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411730
Aligned: 204 rows
Threshold Bit Score: 280.51
Created: 30-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
active siteDNA binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 5 residue positions
Conserved feature residue pattern:E D E K DClick to see conserved feature residue pattern help
Evidence:
  • Structure:4RI9: Homo sapiens FAN1 nuclease active site binds barium ion; contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
4RI9_A         17 PYYLRSFLVVLKTVLENEDdm----------lLFDEQEKGIVTKFYQls-----aTGQKLYVRLFQRKL---------SW 72   human
PWN52977      607 RELSTHFNSPPTEAPKIEDarieae--mrrarKVEKENAALALPHLSggs--kssQGSERSGPLSERNQnql---ntiNP 679  Violaceomyces...
KAE8266727    932 AHTTRELVIEALMSVKGQSt------------LAGPDKRWLSSGPSRspra-pssSSGKREGHLRQLTLn-------fDW 991  Tilletia walkeri
PPQ74783        7 PQAKKSDIIATLLSTAASQs-----------iLSFAPEVGGKSKGKAk------dNGIRQTVLPFSSCKrpv---nqsQR 66   Gymnopilus di...
CDW88137      512 ASSLLSFMKLSNEISKKLSk------------GDNQLKERILDAFYKan-----dNSRTYYLEEKSRSLfyrc--lrlFF 572  Stylonychia l...
KIK55162      250 QVNILTMLGKRKTPSDSGPaasssvtqegrlkRMASEKLGPCIQVNQdl----hqLLRKIHIIFYRSTSipktlfldsYL 325  Gymnopus luxu...
SPO40666      687 AAQANRLREELAEVLRGGCi------------QVVPEVRSLVDRVALvyyrgnllGSAALTAAILSRSRrrn---ypiYG 751  Anthracocysti...
KDQ33018      220 PGHDYSYFCQNEKVMTLLEml---------ncLKVEQLKAVAKEMKVkvg---klTKAEIIALLINRSSkqstipfesSP 287  Pleurotus ost...
XP_007395389  346 PLLTPSILARAKKWSYAHQageqah--ipinpSIPSSNSSTLPSVSTsts--tlgSSSACPSTSPSPPLg-------pSW 414  Phanerochaete...
THH16142      124 DHNSASLVELLECLRQTELreva-----kdfkIKTQQNRNLLISQILt------kASKQTTIETFFRPIckh---kgsRP 189  Bondarzewia m...

Feature 1                                                                                         
4RI9_A         73 IKMTKLEYEE---------IALDLTPVIEELTNAGFlqte---------selqELSEVLELL----------SAPELKSL 124  human
PWN52977      680 VLTSQSTSREnals-rfamTEADMTGGVEEAISQLSleelkllakrmgstkgtSRATIIDSLlatksqgtlfGGSQTSPK 758  Violaceomyces...
KAE8266727    992 SGNKTAQSGQ---------LHSSVQSIVGEVVQVPAevrc----------lidRLALVYYRGnvyn---svgSVLKDSIL 1049 Tilletia walkeri
PPQ74783       67 LKQMAMKLLGkc-----irVNKDILRLVKRLHIIGY-----------------RVTEHPTALllp----ellSRFKKRSY 120  Gymnopilus di...
CDW88137      573 FYQKKDAYETl--------LGHDYGFYRYEKFQNYLsdkdr-------npdnhNLKPIFQNRddf-----itFDESSQII 632  Stylonychia l...
KIK55162      326 THFNKREYPP---------YTWSRSIIWQTIEDYQLy---------------eEALDLQELId--------sILDETFVQ 373  Gymnopus luxu...
SPO40666      752 FRRSGFLFPSrdhl-iafeRALEIEARMEHLIQFGKse--------------rDHREALELFe--------sVYPEWQAC 808  Anthracocysti...
KDQ33018      288 VKKPNNSSHLrqst--lgfIITSKHPKPPPLRQNKLpfkpikppsqelvlrglALKQLTKCVr---------LNPDIFDL 356  Pleurotus ost...
XP_007395389  415 ARTQYKLWPVrdal-lryeRALELEARVDEILGTTSs---------------sGARRVVPPS----------IARKGKER 468  Phanerochaete...
THH16142      190 IESGQLHSSEtpqerrlreVIMKILRKCVRINSSVFslfrrv-----nlvyfrCTQHTPNLL----------TASILAFA 254  Bondarzewia m...

Feature 1                                                                                         
4RI9_A        125 AKTFHLANPNGQKQQL--------VDAFLKLAKQRs----------VIGAVILKRAKALAg----------QSVRICk-- 174  human
PWN52977      759 KPRNKAASPKGKGQLSlnfsptgkVGSQTERLKQEmaslp-ggqcvRLVPEVRSLMDRLAmvyyrgemfggAALTTAvls 837  Violaceomyces...
KAE8266727   1050 ERCKKRKFPEVEVQRSndi---fkSRDHLKRYERAcarey-riamlLDGPYEVNRTATNSael-----yigQTAYNAnge 1120 Tilletia walkeri
PPQ74783      121 TKVDHTRSNNIWTSREe-------VLAYEKALHLEt----------LLDEVIEGPKDKDKvpq-----trnQSRPPAkep 178  Gymnopilus di...
CDW88137      633 GATFDFLSINLKRRDLe-------CKLATKIIKRTl---------rILGVEYRKDNREFLlfdnlralhqdSEVGTKvsd 696  Stylonychia l...
KIK55162      374 PKEFTPEKTSGLKTRFrt-----pVTPVRDLATRQ-----------STAPPSVRKATPVKee--------eGDVKLTad- 428  Gymnopus luxu...
SPO40666      809 VDECVRAHPDGVDKLVyhrm-rfhPGWVLSRVVYKgaaclarfklhDRERDVLTRLLDQRvfrrgrrgdwyDRLALItal 887  Anthracocysti...
KDQ33018      357 LMRINIIAFRSTELPKsial-palLTAFKKRTYTRyafkr-ttgvwADRDDFLDYYKALQihari-eslidQQVPLPssp 433  Pleurotus ost...
XP_007395389  469 AHTGSVLSAVGRTTPAg-------VTVSVSPEKGRl---------sVTSAASTSIADEDVfpain--eevnDNARVRgar 530  Phanerochaete...
THH16142      255 RKRFYPAYEHTRTSDIwa-----tRDALLAYERALey-------aaKLDALLEGHTSSIArars----tfsQTPALTits 318  Bondarzewia m...

Feature 1                                                                                         
4RI9_A        175 -------GPRAVFSRILLLFSLTDs----------mEDEDAACGGQGQLSTVLLVNLGRMEFPSYTINRKTHIFQ----- 232  human
PWN52977      838 rs-krrnYPSYTFSRSPFLFPSRDhllaf---eraiGTELKMEQLLTFGNSEEDLRQAKEHFESVYDEWKEAVKEcsea- 912  Violaceomyces...
KAE8266727   1121 al-pppkSPEALAAGVALFEEILQe----------wKDAVAECEKDCPDGGDRITYHRMRFHPGWPLTRVMYKAGtc--- 1186 Tilletia walkeri
PPQ74783      179 i---tsaGGKHLQTPLKMPATISNlr---------tPISPAVKGEDDLDQKVFNPPEDDLHDADIDVKKEVQVKRhidkw 246  Gymnopilus di...
CDW88137      697 dkhqfidRYRSEWSYLRILDALFPile------kdkQYQISAITLIFLLQNKIFYTQRGKWWHRLAVNLKHMKNKndalk 770  Stylonychia l...
KIK55162      429 -----etGAGIEYEIVDLAPTLGNdf--------kfNHGDEEGGAKRASPEKLRQAARIVDIYHKTLRRKWDLCLsvalv 495  Gymnopus luxu...
SPO40666      888 ysddarrGKKEALRISIRGIQDPDth---------lIYHDTLQRRIGRLESQLRVPRSEQHDFSYAKLKRTTEVVfegvr 958  Anthracocysti...
KDQ33018      434 s---tnkPPPATPNPAKALATPAKs----------pAKSPVASSSRKKLDDEIDSDYEEEILDSSRQARGKQVKElfvq- 499  Pleurotus ost...
XP_007395389  531 e---vkkIFEEVWPEWLQIPEVKDeleranreleggDEVEAGDEVEAKMDEQADGEEQDAEGPAVKIEEAWDAFAr---- 603  Phanerochaete...
THH16142      319 n---snaEEGSPMKRTGGMHQGSEmgfa-----dggKDRLSPREQAAKEVVKLVFDDGLYSEWQTLIAVKGEEGArs--- 387  Bondarzewia m...

Feature 1                                                                                         
4RI9_A        233 -----DRDDLIRYAAATHMLSDISSAMAng----------nWEEAKELAQCAKRDWNRLKNh---------pSLRCHEDL 288  human
PWN52977      913 --hpdGIDRKVYHRMRFHPGWILSRVVYkgagclarfkqhdREKEVLTALLDQKVFRRGKRgdwyd-rlaliTAHYSEDK 989  Violaceomyces...
KAE8266727   1187 ---fsHLKQHHREKEILRLLLDQKVFCRgk----------rGDWYDRLALLEERYCEQKTKggrl---alqiAIRGVEDP 1250 Tilletia walkeri
PPQ74783      247 -lysmCKESVTRYTSMGRVIAPGLERFCd------------AYVLFRMLGKAVRVLGSLKEyq--------qELEILEFM 305  Gymnopilus di...
CDW88137      771 tcdlaLRDEFVKGDKKNMILKIRLNLFVeinrqq--gklllKNSKAKAKLKGKKDKLQIKKkkss----ktdNIHMMEQL 844  Stylonychia l...
KIK55162      496 -kfekERDASLERFEQGYILARLLGKVAeayal----lhefEEELKILESLIEQRFWRAAKrgkw---yerrALVKDHHL 567  Gymnopus luxu...
SPO40666      959 ldvmlDQDDPGRDGGGDSPGARMSSFLG-------------RQPARSSSPSPSSAKTMRRSa----------SERSLGGS 1015 Anthracocysti...
KDQ33018      500 -eiypKWRVLLTLRNAKDLVEPKDDDEPprigl---erfesGYVYTRMVSKATESFGPLKDyk--------lEYRIIEEL 567  Pleurotus ost...
XP_007395389  604 -----DRLVGLGPPEKSNNNKDEDDVIKeri-------eleSANAEPEKWVSRFHYGHILTrivckgvhalsILKDHEGE 671  Phanerochaete...
THH16142      388 ----nGRDRFHHGYILTRLVAKGFEALHvlk-------eyeRELEVLQALLSQRRWRRGRRg----------SWYDQRAL 446  Bondarzewia m...

Feature 1                                                                                         
4RI9_A        289 Pl------FLRCFT----------VGWIYTRILSRFVEILQRLHmy----------eEAVRELESLLSQRiyc------- 335  human
PWN52977      990 Tqgk--keALKIAVrgiq---dpdTHLIYHDTLQRRIARLESQL-------------RVPKSQQHDFSYSklkrt----- 1046 Violaceomyces...
KAE8266727   1251 Dt-----hFVYLGPlq------krIARLQVAKLTQLPFREQRKFtifnkntvevikiKGFRLDKMLVKSEssssvqtnss 1319 Tilletia walkeri
PPQ74783      306 L-------SQRTWRrg-------kRGEWYRRIAVIYVHLIRRADtk---------ekRFDLQKAYLLLLRnav------- 355  Gymnopilus di...
CDW88137      845 Nk-----sFAQSQG----------IIRDMKRKLNRITMLNSFLDddnpg---gqggiSNVHILDDYSDEEdndkqvg--k 904  Stylonychia l...
KIK55162      568 Pk------ALKLQAe--------qNGWTKEHLALRKKEVWEQTRqn---------lyEALEDEDTHRVYRk--------- 615  Gymnopus luxu...
SPO40666     1016 P-------LKRQQSdeks---pspSGFQVRKPLFKRVKVETFAPtakq-----epapEVLPPIKDEAGQGgr-------- 1072 Anthracocysti...
KDQ33018      568 Lnq---kvWLRGKRakw----yerRAILISRYMWDIFDDIVKEDglsrt---regvvEALNDEDTVLVYRp--------- 628  Pleurotus ost...
XP_007395389  672 LkilgmllSQRAFRrg------rrGRWHERRALILMVHCEKDEEttrra---whavfEALKDEDTHVGESli-------- 734  Phanerochaete...
THH16142      447 I-------LMEKFDkddaeamyyaMDAVVEALEDPDVHLMYRPKl-----------qRRLQRLEKCLRIP---------- 498  Bondarzewia m...

Feature 1                                                                                         
4RI9_A        336 ---pdSRGRWWDRLALNLHQHlkr-------lePTIKCITEGLADpev----------rtgHRLSLYQRAVRLRESp--- 392  human
PWN52977     1047 -tetyIYGTRLDSMAPSKEIPfflt----gspdKKIKVQADGTWTgfsygss---tsvngfQNRKPLLKQIKVEKSra-- 1116 Violaceomyces...
KAE8266727   1320 gdnqqKPKQAWAQLFTKKSSPaksap---gsrmLKGKNAIRGAPSsgpspspprmspandiDTTGFVKRPVLQKEVlier 1396 Tilletia walkeri
PPQ74783      356 --ldnEVGIVFLPDLINRLMKl----------eKTLKLPVEQQTTc---------------EGVLLKPKTIEINARki-- 406  Gymnopilus di...
CDW88137      905 krkkkSKKQLYSDEDEDDEKYstdgdvqnetsdIDEETHTNNIMIfgndksssnicsqtsdLQITEIRSLDTSKELnlsl 984  Stylonychia l...
KIK55162      616 -----SLVGRLDKLEKRLNIAg-----------EDRHQYTEQLRKa--------------yEVVVFAYRAERSFSKp--- 662  Gymnopus luxu...
SPO40666     1073 ----aAPGEGDVGAGYSAPSSs-----------PSSPSANDHVAGasa-----------aaTTPTRPTAAVKREESsdsl 1126 Anthracocysti...
KDQ33018      629 -----SLFRRLERLEKQLHIPe----------aERSKCEGQLSKPkvveleal-rvrtrngNKFLFDANGQHIPHTedkd 692  Pleurotus ost...
XP_007395389  735 ---isCLGETVLIKIVKVHRPalrr----rlfkLQKRLRQLGVSDinfvei----ddpaqrKPVEVYIEGKRINTLlyaa 803  Phanerochaete...
THH16142      499 -----LPERHTCEGVLQKHTEifv-------egERVRNRTTGMHLda-------------tGSIAFAAPEMPGKQSqls- 552  Bondarzewia m...

Feature 1                                                                                         
4RI9_A        393 ------sCKKFKHLFQQLpem----------avQDVKHVTITGRLCPq----------rGMCKSVFVMEagea------- 439  human
PWN52977     1117 -----qpIETFAEILEPMgsci--------kqeIDRDPDSLPDFIDPvesra---adehRNVEPKMVRKdvkasmr---- 1176 Violaceomyces...
KAE8266727   1397 f-gtspgPSRLRSPQMNPassvdaivvedddenDLSEVYEVIGRQIKn-----------DMHTAWRGLD----------- 1453 Tilletia walkeri
PPQ74783      407 -----stPLRFDSLGRLIeek---------entPDLLAYMIPTKAFPkleep---vlkkNTGKSCWQGK----------- 458  Gymnopilus di...
CDW88137      985 n-pdvliEKEKKSTYDQLqrsce-----skinkEYFKEVFLNARRNFn----------gEHLKSVYLDKk---------- 1038 Stylonychia l...
KIK55162      663 ------nEEPYKWKGKQK---------------EDITAFLIRPRMPAnsedep-edssaGLPRFPSSTGksvwk------ 714  Gymnopus luxu...
SPO40666     1127 tddlaldGIDAPALLQEDp-------------tLFSLGLNSAAELTPvetr----ketrSSMRSVWRGLd---------- 1179 Anthracocysti...
KDQ33018      693 kensvipATPAKRTYHQMtlt---------dmpQSARSRGLGALITPs-----------PSCSQTSPSKtknpvakwvgk 752  Pleurotus ost...
XP_007395389  804 g-dpiasAKVAKSRGSGVnkrr-------kverEDKKQMKLPFMFAAv----------aPVEKLVPVLDakpksstg--k 863  Phanerochaete...
THH16142      553 -----fvVTKSPHMQRKGraat-------pakeKVPVEVKLMLCLCRsfadffplggiqQKGKSIWVGKd---------- 610  Bondarzewia m...

Feature 1                      #                                                                  
4RI9_A        440 ---adptTVLCSVEELALAHYRrsg--fdqGIHGEGstfstLYGLLLWDIIFMDgiPDVFrnacQAFPLDLCTDSFFTSR 514  human
PWN52977     1177 svwrgldNEPCHVEELCLQHFAeqg---frGYHCEGgvltmLFALLMWDVLFLPv-EGAFetpyQMAPLDLGTDAFCIAR 1252 Violaceomyces...
KAE8266727   1454 -------KQPCRVEHLVLQHFEkdg---fkGVHDEGsvlttLFVLAMWDVIYMSv-EGAFetryQSEPLDMRSDAFAIVR 1522 Tilletia walkeri
PPQ74783      459 -------DGIVNVETIVLEHYEalg---ftGFHSETrllttIFALLFWDIIFAKv-PGAFetpfQFAPLDMFEDTFYHAR 527  Gymnopilus di...
CDW88137     1039 ------sNKFFNVENLALHYYGqkq--kwnGAHVENslmkyMYGIMMWDEIFNDdiPYVFqttyQFQPLDFDYPEFYTHR 1110 Stylonychia l...
KIK55162      715 ---tidgADTCNVEQRALQYYAseegggyqGLHSETcilttVFGLLFWDILFANv-PGAFetkfQIAPLDLMEDSFHDSR 790  Gymnopus luxu...
SPO40666     1180 -------GRPCHVEQLCLQHYAqqg---frGSHCEGkvltmIFALVMWDVLFRSdvEGAFetpfQAAPLDLGSDAFAVVR 1249 Anthracocysti...
KDQ33018      753 svwvgrgGDEVNVETRALQYYErqg---fkGFHSETsilttLFALLFWDIIFWDv-PGAFetpyQTEPLDLRDEIFYYAR 828  Pleurotus ost...
XP_007395389  864 tvwrgrdREEVSVEMFALQHYEaqg---ykGLHSEGrvvttLFGLLFWDIIFAPv-SGAFetpyQSAPLDIAEDSFYLAR 939  Phanerochaete...
THH16142      611 -------REQVNVETLALEDYQnrg---ykGYHSEGrivrtLFGLLFWDVLFAPi-PGAFetpyQSAPLDIADDTFFFTR 679  Bondarzewia m...

Feature 1                                                                                         
4RI9_A        515 rpalEARLQLIHd--aPEESLRAWVAATWHEQEgr--vASLVSWDRFt-sLQQAQDLVSCLgGPVLSGVCRHLAADf--R 587  human
PWN52977     1253 aseiRDRLWLIE----ETGGLDLIKATDERERPkk-twAVGCRWDEYg--AEDLLEIAECMgGRSLSVICQMLCEEw--E 1323 Violaceomyces...
KAE8266727   1523 rdqiTQRLSAIA----EIGGLEFIMAADERERPrq-twASGCNWDYS---REMLLEVTECLgGRPLSTICQILCEEr--Q 1592 Tilletia walkeri
PPQ74783      528 kdliDARLKEIQegdaGWQKILQRHDDAYREKRt---wCIGIHWDLCs--KEELFDIFKCIgKDSLAFICKLFCQDyrgR 602  Gymnopilus di...
CDW88137     1111 kkliDDKLQRIIn--mPRMEIKKYLTSEYEKHKny--hNPIVNWDNIkltKERMASIAYCMgGPLIAMFFEKLAQDf-kN 1185 Stylonychia l...
KIK55162      791 kdsiNARLEELR----NGKALEILNRHDTQYRAnk-twCVGVNWDVCd--KEQLAQIVECMsGETLAVICDLFCHDy-aA 862  Gymnopus luxu...
SPO40666     1250 s--rEIRERLDEi---ERTGGLHLIARADDEQRprrtwAVGCRWDLFg--REELLEVAQCLgGRAIAVVCQMFCEEw--E 1320 Anthracocysti...
KDQ33018      829 kdivDVRLKEIRg--gWAKDIIEKHDKMHREKKt---wCVGMSWDLCe--CSDLIEIAECLgGTALAGICRLFCEDy-sG 900  Pleurotus ost...
XP_007395389  940 rtlaDARLKDIE----TGKGLEVLLRTWDTHMKkk-tfCIGVQWELLq--KEAFVEIMECFkPICLSVICRTLLEDy-aN 1011 Phanerochaete...
THH16142      680 qeliKARLSEIEe--gKAREILEAVDDQHREKKt---wCVGVQWDIFe--RQDLIEIIDCFeGRSLAIICRLFCEEy-aR 751  Bondarzewia m...

Feature 1                #              # #   #                                        
4RI9_A        588 HCRGglPDLVVWNSqsRHFKLVEVKGPNDRLsHKQMIWLAELQKLgAEVEVCHVva----vgAKSQSLS 652  human
PWN52977     1324 HCTGgmPDLCIWRYkdRTVRFVEVKGPGDRLsETQKVWIDILLRAgVDVQVGLV--------VEGKKGG 1384 Violaceomyces palustris
KAE8266727   1593 HCQSgmPDLCVWNMktKEVRFVEVKGPGDELrSKQLVWLEYLYRAgAKVQLASVsdikdlpaAKREPRS 1661 Tilletia walkeri
PPQ74783      603 QSGG--PDLFVWKAqeGLCKFVEVKGPGDRPsEGQKYWFDSLRRAnVEVEICRVvd----ecAKTEPPV 665  Gymnopilus dilepis
CDW88137     1186 WGYGm-PDLVLWREdkAAIKFVEVKSENDNVsEQQKCWIYNITECgIDVEVCWIt-------DKVEGVD 1246 Stylonychia lemnae
KIK55162      863 RASGv-PDLIVWNHeeRKCKFVEVKGPGDRArDNQTLWFDTLLGAgLEVDLCRIqe----dnTKNRNKE 926  Gymnopus luxurians FD-31...
SPO40666     1321 HCTGgmPDLVIWRMrdRCVRFVEVKGPGDRLsETQKVWIDVLLRAgVDVQVGLVv------eAAGDGGG 1383 Anthracocystis flocculosa
KDQ33018      901 RSSGv-PDLIVWNPttKECKLVEVKGPGDTErENQKLWMDALLNVgVGVELCRVyesgkppnGKDRSKA 968  Pleurotus ostreatus PC15
XP_007395389 1012 RTGGl-PDLFLWHPteKLCKFVEVKGPGDNLqENQKLWIDVLLQAkITVEVCHVae-----rGKSKLKG 1074 Phanerochaete carnosa HH...
THH16142      752 RCSGl-PDLLIWNHerRECKFVEVKGPGDSLqENQKLWIDVLLRAnVPVEVCRVv-------ERGQTPT 812  Bondarzewia mesenterica

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