1KNV,1CFR


Conserved Protein Domain Family
Bse634I-like
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cd22314: Bse634I-like 
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Restriction endonuclease Bse634I and similar endonucleases
Bacillus stearothermophilus restriction endonuclease Bse634I recognizes the nucleotide sequence R|CCGGY (R = A or G, Y = T or C, with | designating the cleavage site) and is an isoschisomer of Citrobacter freundii restriction endonuclease Cfr10I; it is active as a homotetramer and belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411718
Aligned: 26 rows
Threshold Bit Score: 255.26
Created: 10-Jan-2019
Updated: 30-Sep-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitetetramer
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1KNV_A         9 NCVEEYKeng------ktKIRIKPFNALIELyhhq-------------tptgSIKENLDKLENYVKDVVKAkgl-aiPTS 68  Geobacillus ste...
KNX32997       7 NCVEVKKe---------gKITIKPLTALAECfedt-------------lpsgDISEILDNLKSYVKQVCKAkay-inPST 63  Bacillus amylol...
WP_103376747   7 EAFILNSat--------gKGQIVPSHALDDLygas-------------lpqlPIVATLEQLTKHISDVANAkgl-alPSR 64  Sulfobacillus s...
OAB35907       2 NLYESKSvekie--ggpsNLRIKPIYALEEVfnnt-------------lptgPIKIILDNLEQHIRNAAKAkdl-dqPSL 65  Paenibacillus g...
KKW38318      11 LLLIVYSvhmda-efvdaKGGVKKEAAIGARftde-------------fpegNIEELLQSIQTTVISYAKKnkl-kiPAQ 75  Candidatus Peri...
RNC62889      10 PCVELKKdq--------sNVVIHGNKVIACVysss-------------lpqgDLDTIMEELQDRVKTVHHQlgytysGSH 68  Candidatus Dich...
WP_084664987   5 NCTTPRClsvekgkdgkqRVKLSSIESSKCLlkylsqkp------lselvgkVTSDLLDELQNGIKKASQKhyg-iePRD 77  Thermanaeromona...
BBD63449       4 NFLFLNTd---------gNISVKADMAFIKLypll-------------pketLINEIHEKIYDLVVAKSKEefnglqPTP 61  Nostoc sp. HK-01
WP_004843302  20 TIINTRDqkn-----nnvTSGIPTTETLADVygtglpsstmeisdfvhslhqQALQNFNDANVYLASIGSSdi--slPSG 92  [Ruminococcus] ...
OBQ24936       5 TAWFTEKsn--------gKVSINGKDIYRNLspeivi---------kladnlSVSEILEWIENEIINAFKEkys-ksPEV 66  Aphanizomenon f...

Feature 1                   #                                                                    
1KNV_A        69 GAFSNTRGTWFEVMI----AIQSWNYRVKRELn-----------dYLIIKMPNVKTFDFRKIFd------NETREKLHQL 127 Geobacillus ste...
KNX32997      64 NALSNVNGKWFEVIV----AIYAWNYLIENKIk-----------dISIIKLPNKQTFNFQRIFn------EKSRTLLNDL 122 Bacillus amylol...
WP_103376747  65 EALSNARGTWFETLV----VASAWNYIINLGIt-----------dTLVVQLPNVQRFDFRNLFd------QSSQSMLDDL 123 Sulfobacillus s...
OAB35907      66 AAFSNVRGLWFEIII----SVYAWNYRINNGLs-----------dCFIIKMPNMKTYDFRRIFd------NLTLKMLDQL 124 Paenibacillus g...
KKW38318      76 AAFNNARGDWLELIL----AAHFWNAVIDRNId------------MLVLRLPNVAKMEFIKIFd------EEAQERIQSG 133 Candidatus Peri...
RNC62889      69 NAFNNIRGAWTRHIF----SYIGWNMFCNNSNvg----------nSCIVPLPSISVLKFTDLFd------TDASEALKSG 128 Candidatus Dich...
WP_084664987  78 QSFNNVRGAWFEKVV----SFWLWSRWYEYCKnig-------gipYFVLKLPDAAKFNFVKIFc------SEEEEKVIGS 140 Thermanaeromona...
BBD63449      62 GSLNNCKGRWNEMSF----LLTAHNSIIKNTNd------------IYLVKMPNESSLKFWQIYt------HESRAVYEKL 119 Nostoc sp. HK-01
WP_004843302  93 SAFNNCNGKWTEYAY----AAFAWNSLAKINTtnkttaqngthsvYVYIKLPNRNSENNDWTQlllpnitQALSNYPQTQ 168 [Ruminococcus] ...
OBQ24936      67 GALNNAKGGWNEYIAtsllSEIIFDINTKTSKyiaif---pipnsQFKIKGSNESYSNFLNLFa------PEDFCNINNY 137 Aphanizomenon f...

Feature 1                              ##                                                        
1KNV_A       128 EKSLLth-----kQQVRLITSNPDLLIIRqkdliksey-nlpinkltHENIDVALTLFKDIEgkckw------------d 189 Geobacillus ste...
KNX32997     123 EKSLTla-----nPQVKMITSNPDILIIRqkdlkktfh-nekiknmsVHNMKIIDNSYKDLEgrcew------------s 184 Bacillus amylol...
WP_103376747 124 ERSLRrh-----eVDVEMVTSNPDLIVIKskdmlsrla-prkianlsLANQHYLSGFYENLRtkcpw------------d 185 Sulfobacillus s...
OAB35907     125 EGSLKnn-----dSKIRLIPSNPDMILVHqkglisna--ddlitnlsEKNVEKLTRLYHEINgrcew------------s 185 Paenibacillus g...
KKW38318     134 LMRTLe------eHDARLDMSNPDLIGVRidrsslppefhkrldrlgAADAHMLFDAYKHLIgkcpy------------n 195 Candidatus Peri...
RNC62889     129 LLRRLs------qQGVELTMSNPDFICVSditpedmaefetpitnlsIETQIKLSNAYTVIKnccsy------------s 190 Candidatus Dich...
WP_084664987 141 LKKHLd------nHGVALETSNPDFVVVTlkagehksc-pvkhkdfsLENLGRLEDLYRNFEylenlyrgfr--nkckyt 211 Thermanaeromona...
BBD63449     120 VSKLKn-------QGFFIRCSNPDFVLIKrrvven------fipneeEDLLSNLKDLYKNVKnkcep------------s 174 Nostoc sp. HK-01
WP_004843302 169 SAKIVspansnygRRFELISSNPDAVILKydsstirtl-wqntgitnFDPYSDIPNLSTDITchldslfnyfrntvlpss 247 [Ruminococcus] ...
OBQ24936     138 LSKIKp-------FKEQIFMPSPDYIIIDlesslys----kdvnlllQEQMRDPDSFVVYNFfkgklh----------ie 196 Aphanizomenon f...

Feature 1              # #             #                                                         
1KNV_A       190 slvAGVGLKTSlrpDRRLQLVHEGNILKSLFAHLKMrywn-----------pkaEFKYYGASSEp--VSKADDDALQTAA 256 Geobacillus ste...
KNX32997     185 sliGGIGLKTSlrpDRRSQLVHEGNILKSLFAHLKMrnwn-----------kdvYFKYYAASMSk--VSGKDQDALETAA 251 Bacillus amylol...
WP_103376747 186 sivAGIGLKTSvrpDRRLQLVHEGNILKSTFAHLKMrhwn----------rdfrFLYVVASSEK---FNDADKKALKTAA 252 Sulfobacillus s...
OAB35907     186 sifAGIGLTTSmrpDRRLQLVYEGNILKSIFAHLSTrhwn-----------nkvSFQYYGASSVk--HSNADDEAFQTAA 252 Paenibacillus g...
KKW38318     196 silFGISIKTSlrgDRRYQIVHEGSIVKAFIAHLQTrywd-----------tsfETKFYGAVTDn--VSDNDHEIFRTAA 262 Candidatus Peri...
RNC62889     191 slkFGIAMKTSlrsDRRYQIAYEGSILKALIAHLQVrywd----------tdfqTYYYAVVANK---VSNDDRAVLSAPA 257 Candidatus Dich...
WP_084664987 212 dviCAIGVKDSlrpDRRLQLVYEGNIFKAVMLHFKTrfwd----------ysyeIPPFYAIVNGkkaPGKKDARALITAT 281 Thermanaeromona...
BBD63449     175 dviSFISLKTSnrpDRRYQILYEANITKYASQYIHNaeh-------------rlRFDVIGRSNEs-dAQVFKAPLLSSIP 240 Nostoc sp. HK-01
WP_004843302 248 nlqCFLSIKNSirpDRRYQWVHEGDHVKTILQWIQVysamgmapldtaltyndlNGKFFAISLSn--VSNADTEALNTGL 325 [Ruminococcus] ...
OBQ24936     197 dikAAVSLKTSnrpDRRYQPLFEAAMIKAMGYVLKQ------------------NWKYYMVASD---LSTADKTIFNSAI 255 Aphanizomenon f...

Feature 1                                                    
1KNV_A       257 THTIVNVNs----TPERAVDDIFSLTSf----EDIDKMLDQIIK 292 Geobacillus stearothermophilus
KNX32997     252 THTIVNVNs----TPERAVDHLFHISNt----EQIPKMFDQILN 287 Bacillus amyloliquefaciens
WP_103376747 253 THTIVNVDa----TPERSVDELYWLTEf----EDVERMLGDVIT 288 Sulfobacillus sp. hq2
OAB35907     253 THTIVNVNs----VPERAVDGIFSLQNt----DDINKMLDEITR 288 Paenibacillus glacialis
KKW38318     263 THSIVNVFs----PSVRAVDKVYHVPTt----NDVNDMIKKIIN 298 Candidatus Peribacteria bacterium GW2011_GWB1_54_5
RNC62889     258 THSIVDVHt----PPVKAIDDIFEVKStddlkQGIQIMIDRSFP 297 Candidatus Dichloromethanomonas elyunquensis
WP_084664987 282 TSTLVDIRl----RPERAVDETFYAGRl----GDIDQVFSKIKE 317 Thermanaeromonas toyohensis
BBD63449     241 IFRIENLEeelelLKSLAIDSDTNISTk----IELDKYWEIFSS 280 Nostoc sp. HK-01
WP_004843302 326 VGSIVSPMl----GPVWAVDKLISCTNf----SQIDSQMQLMLN 361 [Ruminococcus] gnavus
OBQ24936     256 APHGIALE-----ENFHLVDATYLYARk---aDLLPLVIAAIEK 291 Aphanizomenon flos-aquae LD13

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