5XAU


Conserved Protein Domain Family
cc_LAMB1_C

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cd22300: cc_LAMB1_C 
C-terminal coiled-coil domain found in laminin subunit beta-1 (LAMB1)
LAMB1 is also called laminin B1 chain, laminin-1 subunit beta, laminin-10 subunit beta, laminin-12 subunit beta, laminin-2 subunit beta, laminin-6 subunit beta, or laminin-8 subunit beta. It is a glycoprotein that is involved in the pathogenesis of neurodevelopmental disorders. It also plays a crucial role in both lung morphogenesis and physiological function. Mutations in LAMB1 are associated with Cobblestone brain malformation (COB) with variable muscular or ocular abnormalities. LAMB1 is a component of laminin, a complex glycoprotein consisting of three different polypeptide chains (alpha, beta, gamma). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. This model corresponds to the C-terminal coiled-coil domain of LAMB1, which is involved in the integrin binding activity.
Statistics
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PSSM-Id: 411971
Aligned: 8 rows
Threshold Bit Score: 95.2342
Created: 4-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
trimer
Conserved site includes 40 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Structure:5XAU: Homo sapiens LAMB1 in complex with LAMC1 and LAMA5; contacts at 4A
    View structure with Cn3D
  • Comment:laminin is a complex glycoprotein consisting of three different polypeptide chains (alpha, beta, gamma)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             ##  ## ##  #      ## ##  #  ##  ## ### ##  #  ## ### ## ### ### #####
5XAU_B          2 DARRKAEMLQNEAKTLLAQANSKLQLLKDLERKYEDNQRYLEDKAQELARLEGEVRSLLKDISQKVAVYSTCL 74   human
NP_775382    1712 EAKKRAEKLQEEARNLLLQASEKLQLLKNLEKNYDQNQKLLEDKANELVDLEKAVKELLQEISHKVTVYSTCL 1784 zebrafish
P07942       1714 DARRKAEMLQNEAKTLLAQANSKLQLLKDLERKYEDNQRYLEDKAQELARLEGEVRSLLKDISQKVAVYSTCL 1786 human
XP_415943    1713 DARRKAGLLQEEAKALLAQANSKLQLLKELENTYENNQKVLEDKAKQLVELEETVRSLLQTISQKVAVYSTCL 1785 chicken
XP_007909798  953 EARKRAEKLQNEANELLSHANSKLQLLKELEAKYEENQKALEEKAEMLMGLEKEVHSLLQTISHRVAIYSTCL 1025 elephant shark
XP_014339631  355 DAKKRAEMLQNEAKALLAQANNKLQLLEGLEKAYEENQKTLEEKARELVELEEAVRSLLQAISQKVAVYSTCL 427  coelacanth
XP_018108130 1713 EARKKAQELQKEAKGLLEQANKKLDTIKDLEKTYEGNERILEEKAKQLVQLEETVRSILQAISQKAAVYSTCL 1785 African clawed frog
NP_001264059 1695 DARQKAEQLQQEAKDLLIDATNKLQRLRELERSFAANQHILMGKSQELEGLENEARDVLQELSQKINIYSTCA 1767 zebrafish

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