2N11


Conserved Protein Domain Family
MYO6_MIU_linker

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cd22294: MYO6_MIU_linker 
MIU-linker domain found in unconventional myosin-VI
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins function in intracellular movements. Myosin-VI, also called unconventional myosin-6 (MYO6), is a reverse-direction motor protein that moves towards the minus-end of actin filaments. It is required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. It appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. It modulates RNA polymerase II-dependent transcription. As part of the DISP complex, Myosin-VI may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Myosin-VI is encoded by the MYO6 gene, the human homologue of the gene responsible for deafness in Snell's waltzer mice. It is mutated in autosomal dominant nonsyndromic hearing loss. This model corresponds to a conserved region of myosin-VI, which consist of three helices: MIU (Motif Interacting with Ubiquitin), a common linker helix (linker-alpha1) and an isoform-specific helix (linker-alpha2).
Links
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Statistics
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PSSM-Id: 412090
Aligned: 9 rows
Threshold Bit Score: 82.6446
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
MIU motif
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:MIU motif
Evidence:
  • Comment:Motif Interacting with Ubiquitin(MIU)
  • Comment:involved in myosin VI binding to K11-linked diubiquitin

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ##########################                                                   
2N11_A          2 QQAVLEQERRDRELALRIAQSEAELIsDEAQADLALRRSLdsypvs-------kndgtrPKMTPEQMAKEMSEFLSR 71   human
XP_030201982  709 RQAVQEQERRDRELALRIAQSEAELIpEETQADALLRSNGssgapsspdraaagaggklKGLTMEEMAMEMTELLAR 785  Atlantic cod
XP_007886137  998 KQTVLEQERRDRELAMRIAQSEAELIsEELPMEIATRSVEvksvlpvt----pksggsqSKMTMDEMAKEMSDYLAR 1070 elephant shark
Q9UM54        999 QQAVLEQERRDRELALRIAQSEAELIsDEAQADLALRRSLdsypvs-------kndgtrPKMTPEQMAKEMSEFLSR 1068 human
NP_001004111  998 RQAVLEQERRDRELALRIAQSEAELIpEETPPDAGLRSVAppq--------------klKSLTMEEMAKEMSDLLAR 1060 zebrafish
Q9I8D1        999 HQAILEQERRDRELAMRIAQTGAELStEETKLDVGLCRANgt----------------kLQMTAEQMAKEMSEMLSR 1059 chicken
XP_018120974  998 QQAVLEQERRDRELAMRIAQSEAELI-NEEGPDSALRRAGge----------------kTKLTMEEMAKEMTEILSR 1057 African clawed frog
XP_014347754 1003 RQAVLEQERRDRELAMRIAQSEAELIsEEMQPDLGLRRGAqvqatk--------aaagtKKYDLSKWKYAELRDAIN 1071 coelacanth
XP_002612565 1000 NQAILEQERRDRELAMRLAEDEGQEIvEEPQEAPQLKRSVatk-------------qgsKKYELSKWKYAELRDAIN 1063 Florida lancelet

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