5AJS


Conserved Protein Domain Family
cc_THAP11_C
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cd22291: cc_THAP11_C 
C-terminal coiled-coil domain of THAP domain-containing protein 11
THAP domain-containing protein 11 (THAP11) is a cell cycle and cell growth regulator differentially expressed in cancer cells. It acts as a transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. This model corresponds to the C-terminal coiled-coil domain of THAP11, which is involved in protein dimerization.
Links
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Statistics
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PSSM-Id: 412087
Aligned: 7 rows
Threshold Bit Score: 77.2087
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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homodimer
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:5AJS: Homo sapiens THAP11 forms a homodimer through its coiled-coil domain; contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ###  #  ##  ## ##  ## ##  ## ##  ## ##  ## ##  ##  ##    
5AJS_A         1 SLSSGTTEEELLRKLNEQRDILALMEVKMKEMKGSIRHLRLTEAKLREELREKDR-LLAMAV 61  human
Q96EK4       247 SLSSGTTEEELLRKLNEQRDILALMEVKMKEMKGSIRHLRLTEAKLREELREKDR-LLAMAV 307 human
XP_005992852 193 SLSSRTTSEELLRKLNEQRDIIALMEVKMKEMKATVRQLRITEAKLREEIREKDR-LLSMGV 253 coelacanth
XP_015134639 167 SLSSGTTSEELLRKLNEQRDIIALLEVKMKEMKGSIRRLRLAEAQLREEIREKDR-LLHAAS 227 chicken
Q6IR68       234 SMSSGTTTEELLRKLNEQRDIIALMEVKMKEMKSSIKHLKVTEVKLREELRQKDKdKVSPMI 295 African clawed frog
Q6TGZ4       187 SLTTGTTSTELLRKLNEQRDIIALMEIKMKEMKNTIRQLRVTEARLQDELRQREQeRERLIC 248 zebrafish
XP_007887719 159 SLSSTTTSEELLRKLNEQKDIIALMEVKIKEMKGTIRQLNVGEAKLREELRNKEK-LLSMSV 219 elephant shark

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