4L9U


Conserved Protein Domain Family
cc_RasGRP1_C

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cd22290: cc_RasGRP1_C 
C-terminal coiled-coil domain of RAS guanyl-releasing protein 1 (RasGRP1) and similar proteins
RasGRP1, also called calcium and DAG-regulated guanine nucleotide exchange factor II (CalDAG-GEFII), or Ras guanyl-releasing protein, acts as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor, specifically activating Ras through the exchange of bound GDP for GTP. This model corresponds to the C-terminal coiled-coil domain of RasGRP1, which mediates oligomerization.
Statistics
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PSSM-Id: 412086
Aligned: 8 rows
Threshold Bit Score: 57.4468
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
homodimer
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:4L9U: Homo sapiens C-terminal coiled coil of RasGRP1 forms a homodimer; contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ####  #  ##  ## ##  ## ##  #   #  ## #           
4L9U_A         2 ELRHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQLEkSNHVLAQMEQ 56  human
O95267       739 ELRHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQLEkSNHVLAQMEQ 793 human
XP_025007157 702 REHHSYKPSYQELERERNILKADNEGLKMQLEQAHKTIESLTIQrRNHVIDNLQH 756 chicken
Q6NTL4       733 AELRGGKAGIQELEKEKVFLKEENTALKIQLKDAHRRVETLRAElRKYVLDSDTH 787 African clawed frog
PIO35901     584 EERRASKQTTQELEKEKSLLKEENTNLKTQLKDAQRKMEALRAElRKYVINNETV 638 American bullfrog
XP_030069545 736 KEKEHHCTFTHVESDQESNLRAENEALKIHLKDAQRQIEALKTElRKLQMSDSME 790 Microcaecilia unicolor
XP_028933855 843 PSYRELEQENHALKAENHALKADNEALRFRLRQAQRRMDALSLShGHHGPRPLDP 897 platypus
XP_005993023 687 REEQNCKPTLHQIEKENSNLREENEALQRKLKEAQREIEALRIKlQRFENKEQRD 741 coelacanth

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