6YVH


Conserved Protein Domain Family
CWC27_CTD

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cd22288: CWC27_CTD 
C-terminal domain of spliceosome-associated protein CWC27 and similar proteins
CWC27, also called antigen NY-CO-10, or probable inactive peptidyl-prolyl cis-trans isomerase CWC27, or PPIase CWC27, or serologically defined colon cancer antigen 10, is part of the spliceosome and plays a role in pre-mRNA splicing. It is a probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. This model corresponds to the C-terminal domain of CWC27, which interacts with CWC22 MIF4G domain.
Links
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Statistics
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PSSM-Id: 412084
Aligned: 33 rows
Threshold Bit Score: 56.542
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
CWC27 binding
Conserved site includes 29 residues -Click on image for an interactive view with Cn3D
Feature 1:CWC27 binding site [polypeptide binding site]
Evidence:
  • Comment:biochemical/structural approaches show that the interaction between CWC22 and CWC27 proteins is direct and mediated by the C-terminus of CWC27 and the MIF4G domain of CWC22
  • Comment:evidences strongly suggest that the CWC22/CWC27 heterodimer can be considered as a building block because it exists independently of the spliceosome
  • Structure:6YVH: Homo sapiens CWC22 in complex with CWC27 C-terminal domain; contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            # # ###### ### ###  #     #        ### #### ######  
6YVH_C         2 SMGTSREDQTLALLNQFKSKLTQAIAETPENdi---pETEVEDDEGWMSHVLQFED 54  human
Q6UX04       376 KKGTSREDQTLALLNQFKSKLTQAIAETPENdi---pETEVEDDEGWMSHVLQFED 428 human
XP_424748    381 KKGVSREDQTLALLDRFKSKLTQAIEETPENev---sESEIDTDEGWMSHVLQFED 433 chicken
XP_005997500 376 KKGATREEQTLALLNSFKSKLSKAILETPADee---tEPDVENDEGWMSHVLQFED 428 coelacanth
XP_007890317 373 KKGSTREEQTLALLDQFKSKLTKAIETPAEEi----iEPEGEDDQGWMSHVLQFDD 424 elephant shark
Q6GLX7       380 NKGVSREQQTLALLDRFKSKLTQAITEPPKEee--asDVDEENDKGWLSHVLQFEE 433 African clawed frog
Q7ZW86       371 KKGSGREAQTLALLESFKSKLSSAISETPSApeedveELAEDDDKGWMAHVLHFDE 426 zebrafish
XP_009412212 396 RRNQGREEDTLAKLQRFKKSLSTKLSSPSSNgs---kDNNEEDDSGWMATQLKFIP 448 wild Malaysian banana
XP_015918636 359 KGTSEREQQTLKFLEKFRTTLQSAKTTVTKKde--ikSSDEEDDETWLAHCLRAED 412 common house spider
GBM00232     361 KGTSEREEQTLKFLEKFKSSMEKAKQVHRDEee---vMSDEDDNEAWLAHRLRADD 413 Araneus ventricosus

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