5NTB


Conserved Protein Domain Family
DPBB_SPI-like
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cd22273: DPBB_SPI-like 
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double-psi beta-barrel fold of Streptomyces papain inhibitor and similar proteins
Streptomyces papain inhibitor (SPI) adopts a rigid, thermo-resistant double-psi-beta-barrel (DPBB) fold that is stabilized by two cysteine bridges. SPI serves as a glutamine and lysine donor substrate for microbial transglutaminase (MTG, EC 2.3.2.13) from Streptomycetes, that is used to covalently and specifically link functional amines to glutamine donor sites of therapeutic proteins. SPI is a stress protein produced under hyperthermal stress conditions, and is able to inhibit the cysteine proteases, papain and bromelain, as well as the bovine serine protease trypsin.
Links
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Statistics
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PSSM-Id: 439253
Aligned: 17 rows
Threshold Bit Score: 128.23
Created: 23-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5NTB_A         8 MTGKMTYYTDkgYGACGTpidasSQDLVAIPAAWWttpnpn------------ndplcrGVSVEVSYnGRTIRVPVRDKC 75  Streptomyces mo...
P86242        41 MTGKMTYYTDkgYGACGTpidasSQDLVAIPAAWWttpnpn------------ndplcrGVSVEVSYnGRTIRVPVRDKC 108 Streptomyces mo...
WP_150499426  37 RQGKATFYNDagTGACGKpldaaTQMLVAVSPKWWkaenpn-------------rdplcHAKVRLTFrGKTITVPVRDKC 103 Streptomyces ch...
SFR28711      41 IDGKATYYDDagLGACGQnidasTEVLVAVSPVFWtapnpn------------ndrlcrNVFVEVTHnGKKVRAKVKDKC 108 Lentzea waywaya...
XP_003290516  22 YYGEATYNKGagSGVCGRtfdtnSEVFASLPSSFWstgsn--------------sdplcSSKIRVKYnGKTIDVPVRDKC 87  Dictyostelium p...
SDM89156      29 KSGNATYYNLsgAGACGDhinarTQLLVAVSDSWFgsgdpn-------------ndpicKKKLKVTYgGKSVTVSVKDKC 95  Allokutzneria a...
WP_071900353  26 GNGDLRYYNAagYGACGTqingaKELFAAVPSRYWtasnpn-------------kdplcKQLVLVTYdGKSIKVPVKDKC 92  Cystobacter fer...
ADX36366      27 FTGSFTFYNDkgFGACGQqinaeTEMLVAISHTQWiggnpn------------ndpicrNICLKVDYkGKSITVPIKDKC 94  root-knot nematode
ABV60414      28 KGGEFTYYNAvgDGACGRt---lTGCVAAVAPTLFdpsakwvasdlpdkryvlgdkvcqGMCVKVEYkGKTASFPIEDKC 104 pine wood nematode
ACV31311      33 TNGVFTFNEAtgRSACGLda-gkPKMSASVSGKLFksdgqwknacridqqymlddpickNICVKIDYkGKSLTVPINDKC 111 Globodera rosto...

5NTB_A        76 PSCdRTHIDLSQAAFAKLApld-rgVVNGITWKF 108 Streptomyces mobaraensis
P86242       109 PSCdRTHIDLSQAAFAKLApld-rgVVNGITWKF 141 Streptomyces mobaraensis
WP_150499426 104 MECgSKHIDLSQPAFARLAdps-kgVIHKVKWKF 136 Streptomyces chartreusis
SFR28711     109 MGCgRDHVDLSLPAFRKLAdp--gqGVINVKWKF 140 Lentzea waywayandensis
XP_003290516  88 TRCsTNVLSLSAPAFKDLVgsl-ndGNIGISWEF 120 Dictyostelium purpureum
SDM89156      96 PGCsKAHFDLSEKAFKKLApl--srGNIDIKWEW 127 Allokutzneria albata
WP_071900353  93 PGCsANTLDLSQPAFQQLGnld-lgILKGASWSI 125 Cystobacter ferrugineus
ADX36366      95 PSCdSTHADLSQAAFAQLEnla-vgHAFNALFTY 127 root-knot nematode
ABV60414     105 PGCqENHVDLSENAFKILExnlgvgKAKDATITY 138 pine wood nematode
ACV31311     112 PECpPNNVDLSIDAFTYLEsra-vgKATGATLTY 144 Globodera rostochiensis
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