Conserved Protein Domain Family
Rcc_KIF21B

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cd22262: Rcc_KIF21B 
regulatory coiled-coil domain found in kinesin-like protein KIF21B
KIF21B is a plus-end directed microtubule-dependent motor protein which displays processive activity. It is involved in regulation of microtubule dynamics, synapse function, and neuronal morphology, including dendritic tree branching and spine formation. KIF21B plays a role in learning and memory. It is involved in the delivery of gamma-aminobutyric acid (GABA(A)) receptors to the cell surface. This model corresponds to a conserved region of KIF21B, which shows high sequence similarity to the regulatory coiled-coil domain of KIF21A.
Statistics
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PSSM-Id: 410203
Aligned: 6 rows
Threshold Bit Score: 132.622
Created: 30-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens KIF21A regulatory coiled-coil domain forms a homodimer

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            ##  ## ##  ## ##  ## ##  ## ##  ##  #  ##        ## ##  ## ##  ## ##  ## ##  
O75037        929 QRMTIVNLEADMERLIKKREELFLLQEALRRKRERLQAESPEEEKgl---qELAEEIEVLAANIDYINDGITDCQATIVQ 1005 human
XP_007892461  930 QRMTISNLEADMNRLLGKREELIGLHETLVGKKQRILKENPDDNKmv---qEINEELEALNANIDYINDSISECQATIME 1006 elephant shark
XP_014351922  932 KRMTVINLETDMDRLLKKREELTILQEGLVRKRQKVLSETPGCERvv---qELNEEIDALNANIDYINDNISDCQATIMQ 1008 coelacanth
XP_004934871  931 QRMTIINLEADMERLIKKREELALLQEALLGKRAKLQAESPKEQKgl---qELNEEIEVLGANIDYINDSISDCQATIMQ 1007 chicken
XP_018102044  884 QRLTLLNLESDMERLLRKREELSLLQEALISRTVVPPEDRKEDEKaq---qDVAEELEVLTANIDYVNDCIRECQATIVQ 960  African clawe...
XP_009304054  960 QRMTITNVEADMDRLIKKREELSVQQEALLRKREKLLSESFREEDeerllqEMNEEIEVLNANIDYISDSLSDCQATIVQ 1039 zebrafish
Feature 1         ##   
O75037       1006 LEETK 1010 human
XP_007892461 1007 IEEAK 1011 elephant shark
XP_014351922 1009 IEETK 1013 coelacanth
XP_004934871 1008 IEETK 1012 chicken
XP_018102044  961 MEETK 965  African clawed frog
XP_009304054 1040 IEETK 1044 zebrafish

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