5D5K


Conserved Protein Domain Family
PARP2_NTR
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cd22252: PARP2_NTR 
NTR (N-terminal region) domain of poly [ADP-ribose] polymerase 2 (PARP-2) and similar proteins
PARP-2 is also called ADP-ribosyltransferase diphtheria toxin-like 2 (ARTD2), DNA ADP-ribosyltransferase PARP2, NAD(+) ADP-ribosyltransferase 2 (ADPRT-2), poly[ADP-ribose] synthase 2 (pADPRT-2), or protein poly-ADP-ribosyltransferase PARP2. It is a poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. It mainly mediates glutamate and aspartate ADP-ribosylation of target proteins. PARP-2 can also ADP-ribosylate DNA; it preferentially acts on 5'-terminal phosphates at DNA strand break termini in nicked duplex. This model corresponds to the NTR (N-terminal region) domain of PARP-2, which contains a nucleolar localization sequence (NoLS) and a putative nuclear localization signal (NLS). The NTR domain has a helical SAF-A/B, Acinus, and PIAS (SAP) domain fold and may participate in protein-protein interactions.
Links
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Statistics
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PSSM-Id: 412075
Aligned: 8 rows
Threshold Bit Score: 78.7866
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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importin alpha
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:importin alpha binding site [polypeptide binding site]
Evidence:
  • Structure:5D5K: Homo sapiens PARP-2 in complex with importin alpha-1; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #####       ### #######                                                  
5D5K_B        39 ESKRVNNGNTAPEDSS-PAKKTRRCQRqeskKMPVAGGKaNKDRTEDKQd-------------eSVKALLLKGK 98  human
Q9UGN5        19 ESKRVNNGNTAPEDSS-PAKKTRRCQRqeskKMPVAGGKaNKDRTEDKQdgmpgrswaskrvseSVKALLLKGK 91  human
XP_005341458  17 ETKKINNGNSTTEDSP-LVKKARTCERkgvkKDHAAGEE-AKNRTEDRQe--------------TVKALLLKGK 74  thirteen-lined ground...
XP_008267516  31 ASVAVNETNSVTEDSP-PVKKTRRCQKlemkKEPSAGKKaDKEGTEDKQg-------------eSVKALLIKGK 90  rabbit
XP_012891173   8 SSGLRKQGRTAAKDSP-PAKKTRTCQRkgmkKGLVDGEKnDEDRTKDKQe--------------TVKALLLKGK 66  Ord's kangaroo rat
XP_012589422  20 KDTGRVNGNTAAEEPP-PTKRSRRCGRqvveKEPVAEGT-PDDATEDKE---------------SVKTLLLKGK 76  star-nosed mole
XP_012788447  21 ETDRISNGNTALEDPP-PAKKTRSGQKknlkNETVALGRpDNNRPGEQQe--------------SVKTLLLKGK 79  European shrew
O88554        17 EAKKVDNGNKATEDDSpPGKKMRTCQR----KGPMAGGK-DADRTKDNRd--------------SVKTLLLKGK 71  house mouse

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