Conserved Protein Domain Family
HkD_Daple

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cd22228: HkD_Daple 
Hook domain found in Daple (Dvl-associating protein with a high frequency of leucine residues) and similar proteins
Protein Daple, also called coiled-coil domain-containing protein 88C (CCDC88C), or Hook-related protein 2 (HkRP2), is a novel non-receptor nucleotide exchange factor (GEF) required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling.
Statistics
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PSSM-Id: 411799
Aligned: 4 rows
Threshold Bit Score: 305.695
Created: 21-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative
Feature 1:putative LIC-binding interface [polypeptide binding site]
Evidence:
  • Comment:the conserved Hook domain interacts directly with the dynein light intermediate chain 1 (LIC1)
  • Comment:based on the structure evidence that Homo sapiens Hook 3 (6B9H) interacts with a dynein light intermediate.

cd22228 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd22228 is a member of the superfamily cl41774
Sub-family Hierarchy
cd22211HkD_SFcd22222HkD_Hookcd22225HkD_Hook1cd22226HkD_Hook3cd22227HkD_Hook2cd22223HkD_HkRPcd22228HkD_Daplecd22229HkD_Girdincd22230HkD_Gipiecd22224HkD_NuMA
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
Q9P219         12 FLQSPLVTWVKTFGPFGsgsqdNLTMYMDLVDGIFLNQIMLQIDPrPTNQRINKHVNNDVnLRIQNLTILVRNIKTYYQE 91   human
P85120         12 FLESPLVTWVKTFGPCGnenesKLAMYMELVDGVFLNKIMVQIDPrPSNQRVNKHVNNDVnRRVQNLTILVRHIKAYYQE 91   African clawe...
A0A2R8QCI3     12 FMDSPLVVWVKTFGPLGfssedKLSMFMDLVDGVFLHKIMTHIDPsPMNQRVNKQVNNDVnLRIQNLNTVIRHIKNYYQE 91   zebrafish
XP_025007141   12 FLQSPLVTWVKTFGALGgggedKLGMYMELADGVLLNRIMLQIDPrPTNQRVNKHVNNDVyLRVQNLTILVRNIKTYYQE 91   chicken
Feature 1                                                 #     #  ## #    #  ## ##  ##  # 
Q9P219         92 VLQQLIVMNLPNVLMIGRDPLsGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTH 164  human
P85120         92 VLQQLIVMNLPNVLLISKDPLtDKSMEELKKILLLMLGCAVQCERKEEYIERIKQLDIETQAGIVSHIQEVTH 164  African clawed frog
A0A2R8QCI3     92 HLQQLIVMNLPNVLAIAKDPLsGKSMEEMKRMLLLILGCAVQCDRKEEIIEKIKLLDIETQAAIVTHIQEVTH 164  zebrafish
XP_025007141   92 VLQQLIVMNLPNVLMIGKDPLsGKSMEEIKKLLLLVLGCAVQCERKEEFIERIKQLDIETQAAIVSHIQEVTH 164  chicken

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