5U4U


Conserved Protein Domain Family
pseudoGTPaseD_p190RhoGAP-A

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cd22221: pseudoGTPaseD_p190RhoGAP-A 
pseudoGTPase domain found in p190RhoGAP-A and similar proteins
p190RhoGAP protein A (p190RhoGAP-A), also called Rho GTPase-activating protein 35(RHOGAP35), glucocorticoid receptor DNA-binding factor 1, or glucocorticoid receptor repression factor 1 (GRF-1), or Rho GAP p190A, or p190-A, is a Rho family GTPase-activating protein (GAP) that acts as a key regulator of Rho GTPase signaling and is essential for actin cytoskeletal structure and contractility. It binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This model corresponds to the GTPase-like domain called pseudoGTPase domain that is located at the middle region of p190RhoGAP-A. Rho family GTPase-activating proteins normally have five highly conserved sequence motifs, termed 'G-motifs', required for nucleotide-binding and catalytic activity. PseudoGTPases would consist of a GTPase fold lacking one or more of these G motifs.
Statistics
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PSSM-Id: 412066
Aligned: 7 rows
Threshold Bit Score: 315.651
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5U4U_A          5 NVDRINLVILGRDGLARELANEIRALCTnDDKYVIDGKMYELSLRPIEGNVRlPVNSFQTSTFQPHGCLCLYNSKESLSY 84   African clawe...
Q6NU25        589 NVDRINLVILGRDGLARELANEIRALCTnDDKYVIDGKMYELSLRPIEGNVRlPVNSFQTSTFQPHGCLCLYNSKESLSY 668  African clawe...
XP_001343636  596 KVDRINLVILGKDGLARELANEIRALCTnDERYVLDGRTYELTLRPIEGNVRlPVNSFHTPTFAPHGCLCLYNSKESLSY 675  zebrafish
Q9NRY4        594 NIDRINLVILGKDGLARELANEIRALCTnDDKYVIDGKMYELSLRPIEGNVRlPVNSFQTPTFQPHGCLCLYNSKESLSY 673  human
XP_005996091  592 NVDKINLVILGKDGLARELANEIRALCTnDDKYVLDGKMYELSLRPIEGNVRlPVNSFQTPTFQPHGCLCLYNSKESLSY 671  coelacanth
XP_007909359  593 SADKLNLVLLGKDGLAHELANEIRVLCT-DDKYVLEGKMYELSLRPIEGNVKhRVNAFQTPSFQPHGCLCLYNSKESLYY 671  elephant shark
XP_025000235  594 NVDRINLVILGKDGLARELANEIRALCTnDDKYVIEGKMYELSLRPIEGNVRlPVNAFQTPTFQPHGCLCLYNSKESLSY 673  chicken
5U4U_A         85 VVESIEKSRESSLgrkenhliNLPLTLILVNRRGdt-----ssETAHSLIQHGQQVASKLQCVFLDAAStGLGYGRNINE 159  African clawe...
Q6NU25        669 VVESIEKSRESSLgrkenhliNLPLTLILVNRRGdt-----ssETAHSLIQHGQQVASKLQCVFLDAAStGLGYGRNINE 743  African clawe...
XP_001343636  676 VVDSIEKLRESTIgrretnlvQLPLSLLLVTKRGvgsisdiggETAQTLIQQGQQVAGRFQCSYLEPASpGVGYGRNIND 755  zebrafish
Q9NRY4        674 VVESIEKSRESTLgrrdnhlvHLPLTLILVNKRGdt-----sgETLHSLIQQGQQIASKLQCVFLDPASaGIGYGRNINE 748  human
XP_005996091  672 IVESIEKSRESTLgrkdnhftHLPITLILFNKRGdt-----sgETLQSLTQQGQQIASKLQCDFLDPAStGIGYGRSINE 746  coelacanth
XP_007909359  672 IKESLEKLRESTMdrrdnhlaQLPLTLVLANKREsg------gETLQSLRNHGQQLANKLQCPFIDVTShSVGSGRNFSE 745  elephant shark
XP_025000235  674 VVESIEKSAAGRRenh---paHLPLTLMLVNKRGda-----ggETLHSLVQQGQQIAGKLQCVFLDPAAaGIAYGRSVNE 745  chicken
5U4U_A        160 KQISLILRGLLESKRNL 176  African clawed frog
Q6NU25        744 KQISLILRGLLESKRNL 760  African clawed frog
XP_001343636  756 KHLNQILRGLLEMRRPS 772  zebrafish
Q9NRY4        749 KQISQVLKGLLDSKRNL 765  human
XP_005996091  747 KQVNQVLKTLLDSKRSS 763  coelacanth
XP_007909359  746 LQITQALKGLLDTMKRN 762  elephant shark
XP_025000235  746 KQISQVLKGLLDSKRNL 762  chicken
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