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H1 domain found in potassium channel tetramerization domain-containing protein 12b Potassium channel tetramerization domain-containing protein 12b (KCTD12b) is a BTB/POZ domain-containing protein that is an auxiliary subunit of gamma-aminobutyric acid type B (GABA-B) receptors associated with mood disorders. KCTD12b consists of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits and is responsible for desensitization. This model corresponds to the H1 domain. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",