1IK9,2R9A,3WTF,6HXY,3Q0X


Conserved Protein Domain Family
HD_XRCC4-like_N
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cd22210: HD_XRCC4-like_N 
N-terminal head domain found in the XRCC4 superfamily of proteins
The XRCC4 superfamily includes five families: XRCC4, XLF, PAXX, SAS6 and CCDC61. XRCC4 (X-ray repair cross-complementing protein 4), XLF (XRCC4-like factor) and PAXX (paralog of XRCC4 and XLF) play crucial roles in the non-homologous end-joining (NHEJ) DNA repair pathway. SAS6 (spindle assembly abnormal protein 6) and CCDC61 (coiled-coil domain-containing protein 61) have a centrosomal/centriolar function. Members of this superfamily have an N-terminal globular head domain, a centrally located coiled-coil, and a C-terminal low-complexity region. They form homodimers through two homodimerization domains: an N-terminal globular head domain and a parallel coiled-coil domain. In addition, some members such as XRCC4 and XLF form symmetric heterodimers that interact through their globular head domains at the opposite end of the homodimer interface, and may form XLF-XRCC4 filaments. This model corresponds to the N-terminal head domain of XRCC4 superfamily proteins.
Links
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Statistics
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PSSM-Id: 408999
Aligned: 5 rows
Threshold Bit Score: 104.931
Created: 20-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
homodimer
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Comment:both the head domain and coiled-coil domain are involved in homodimerization
  • Structure:1IK9; Homo sapiens Xrcc4 forms a homodimer, contacts at 4A
  • Structure:6HXY; Homo sapiens CCDC61 forms a homodimer, contacts at 4A
  • Structure:3WTF; Homo sapiens PAXX forms a homodimer, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      # #              ## #                       #   #                              
1IK9_A      4 KISRIHlvs------epsITHFLQVSwekt----lesGFVITLTDG---HSAWTGTVSEsEISQEADDMam----eKGKY 66  human
2R9A_A     12 PWAWLQla---------eNSLLAKVFit-------kqGYALLVSDL---QQVWHEQVDTsVVSQRAKELnkrltapPAAF 72 
3WTF_A      9 PLCTLPpgp-------epPRFVCYCEgeesg-egdrgGFNLYVTDA---AELWSTCFTPdSLAALKARFgl---saAEDI 74  human
6HXY_A     10 VQEEMKfr---------gSEFAVKVEma-------erLLIVEISDVv-tADQWRGEFGPaYIEDLTRKTgnf--kqFPVF 70 
3Q0X_A     27 FWRPVPvhvkqqdredvlEELTFRILtgvakqnhnlrILRIHISSDsdlFFLHTLEVSEeDFQSLKNDQgil--vdFASF 104 Chlamydomonas rein...

Feature 1                                                                                     
1IK9_A     67 VGELRKALLsgagp----advyTFNFSKe----------------------------sAYFFFEKnlkdvsfrlGSFNLE 114 human
2R9A_A     73 LCHLDNLLRpllkda-ahpseaTFSCDCva--------------------------daLILRVRSelsg-lpfyWNFHCX 124
3WTF_A     75 TPRFRAACEq-----------qAVALTLqe--------------------------drASLTLSGgp-----saLAFDLS 112 human
6HXY_A     71 CSMLESAVHkss-------dsvTLDLLTysdlellrnrkagvvgrpraqpqspalsakRYLILIYtvef-drihYPLPLP 142
3Q0X_A    105 PGKIISLLEkcilaqpgdsprfQAVLTIrg--------------------------geSVFKIVEindekqlphITLAFR 158 Chlamydomonas rein...

Feature 1       
1IK9_A    115 KV 116 human
2R9A_A    125 LA 126
3WTF_A    113 KV 114 human
6HXY_A    143 YL 144
3Q0X_A    159 PG 160 Chlamydomonas reinhardtii

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