2E31


Conserved Protein Domain Family
F-box_FBXO2
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cd22167: F-box_FBXO2 
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F-box domain found in F-box only protein 2 (FBXO2) and similar proteins
FBXO2, also called FBX2, is a neuron-specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It binds specifically to proteins attached with N-linked high-mannose type oligosaccharides, and subsequently contributes to ubiquitination of glycoproteins. FBXO2 regulates amyloid precursor protein (APP) levels and processing in the brain, and may play a role in modulating Alzheimer disease (AD) pathogenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.
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Statistics
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PSSM-Id: 438938
Aligned: 7 rows
Threshold Bit Score: 112.143
Created: 12-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Skp1 binding
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:Skp1 binding site [polypeptide binding site]
Evidence:
  • Comment:F-box proteins participate in SCF (Skp1-Cul1-F-box protein) complexes that function as ubiquitin E3 ligases, where the role of the F-box protein is to recruit target substrates.
  • Structure:2E31; Mus musculus FBXO2 in complex with Skp1, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #   #  ##  ###  # ### ##### #                              # #   #   #
2E31_A        51 LAELPEPLLLRVLAELPATELVQACRLVCLRWKELVDGaPLWLLKCQQEGLvpegsaDEERDHWQQFYFLSKR 123 house mouse
Q9UK22        47 LDELPEPLLLRVLAALPAAELVQACRLVCLRWKELVDGaPLWLLKCQQEGLvpeggvEEERDHWQQFYFLSKR 119 human
EMP41523       1 MDSLPEAVLIQILASIPAVELVLACRLVCCQWKNLVDGaALWTLKCQQEGFtga-epKEEAENWQTFYFLKNL 72  Green sea turtle
OCT70384       1 MENFPDDVLIRILSEVSAEELVLVCRLVCSQWKNIIDGfDLWQTKCMQDGFmet-egETEPTNWRTVYFLNKR 72  African clawed frog
XP_006004332   1 MESLPEAVLVKILAYIPVVELIVVCRLVCRQWKETVDGpAVWVLKCQQDGFacd-slEKQPEDWQVFYFLNAK 72  coelacanth
XP_030041838   1 MEVLPEAILTRIMASLPAEELVLVCRLVCRQWKDIVDApAVWILKCQEEGFsvt-eeRTEEDNWQIFFFLSKK 72  Microcaecilia unicolor
XP_006004331   4 IDDLPETVFVQVLSYLPARELVLTCRLVCSLWKSLVDKkILWIRKCQLEGLsrk-hlQKQPKDWKEFYFLCHL 75  coelacanth

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