2OVP,5V4B,5IBK


Conserved Protein Domain Family
F-box_FBXW7
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cd22133: F-box_FBXW7 
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F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins
FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.
Links
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Statistics
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PSSM-Id: 438905
Aligned: 22 rows
Threshold Bit Score: 118.296
Created: 11-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Skp1 binding
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:Skp1 binding site [polypeptide binding site]
Evidence:
  • Structure:2OVP; Homo sapiens FBXW7 in complex with Skp1, contacts at 4A
  • Comment:F-box proteins participate in SCF (Skp1-Cul1-F-box protein) complexes that function as ubiquitin E3 ligases, where the role of the F-box protein is to recruit target substrates.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      ####  ###  #  ### ##  ## ######## ##          
2OVP_B          2 QVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 60   human
Q9VZF4        875 QVRHMMKVIEPQFQRDFISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWK 933  fruit fly
RUS81954      421 QVRHMMQVIEPQFQRDFISLLPKELALYVLSFMEPRDLLRAAQTCRYWRVLAEDNLLWR 479  eastern emerald elysia
XP_013378993  492 QVRHMMAVIEPQFQRDFISLLPKELALYVLSFLDPKDLLRAAQTCRYWRVLAEDNLLWR 550  Lingula anatina
EFX81440       74 QVRHMMAVIEPQFQRDFISLLPKELALYVLSFLTPRDLTRAAQTCRCWRVLAEDNLLWR 132  common water flea
PIK39914      242 QVRHIMSVIEPQFQRDFISLLPKEVALLVLSFLEPRDILKAAQTCQTWRILCEDNLLWR 300  Japanese sea cucumber
XP_003382807  134 QLKNLMEKIQPQFQRDFISLLPRELSLHVLSYMSPRDLLIAAQTCRMWRTLCDDILLWK 192  Amphimedon queenslandica
EEC03413      158 QVRHMMHVIEPQFQRDFISLLPKELALYVLSFLEPRDLLRAAQTCHYWRILAEDNLLWR 216  black-legged tick
CBY18769      225 NIRFMRDVIEPRFQRDFISLLPPELALHVLSKLEPKDLVSATQTCRTWRQLADDNTIWR 283  Oikopleura dioica
XP_012564598  188 IVRHMMAKIEPYFQRDFISLLPKELALYVLSFLEPKHLCKAAMTCRYWRVLAEDHLLWK 246  Hydra vulgaris

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