Conserved Protein Domain Family
F-box_FBXL15
?
cd22126: F-box_FBXL15 
F-box domain found in F-box/LRR-repeat protein 15 (FBXL15) and similar proteins
FBXL15, also called F-box only protein 37 (FBXO37), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Smad ubiquitination regulatory factor 1 (SMURF1), thereby acting as a positive regulator of the BMP signaling pathway. It is required for dorsal/ventral pattern formation and bone mass maintenance. It also mediates ubiquitination of SMURF2 and WWP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.
Links
?
Statistics
?
PSSM-Id: 438898
Aligned: 38 rows
Threshold Bit Score: 42.1022
Created: 12-Jan-2019
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
 
putative Skp1
Feature 1:putative Skp1 binding site [polypeptide binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1           #     #  ##  ##   # ##   ### #             
Q9H469        19 FLDLPweDVLLPHVLNRVpLRQLLRLQRVSRAFRSLVQl--HLAGL 62  human
XP_027215972   6 LTDLPweDVIYCYIFPHLsAADLWRFRGVCKQFEALYCt--YMQAC 49  Pacific white shrimp
NP_001036332  41 LFDVCwdDVLIPQVAVYLsLKDLFNLRCCSRTAQRFVEa--ALEKR 84  fruit fly
RXG72336       8 LLHIPweDIIFDRIFTYLkLRDIIMLRILSTHYKALITe--YLRVV 51  common pillbug
EDV25611       5 VFSLPweDVIFTSILPFLtLMEVCNLRLVCKSFNQLCLe--YFTCC 48  Trichoplax adhaerens
EDO44852       9 LFSLPrlDITFKYILPRLyYDELYKCRRVCKSFKELCDe--YFRTL 52  starlet sea anemone
XP_018903799   5 FISLLqeDIIYPYIFSKLsLKDYFNLRCLSKAYKELVDc--YFQQL 48  Bemisia tabaci
XP_023326260   3 LTDLSleDILIPQIFPLLsYRDWLNIRSTSRALCSIIQv--FLSKN 46  Eurytemora affinis
XP_018321770  17 LFNIPwdDVLVPYIGPTLsVKDCFNLRCVSRSGKSLGEs--ILKKV 60  emerald ash borer
EGD77728      62 LFTLPq-EVIHAYVFPHLeAHDIQHLRRTCRAMRSIVDalrHRRKR 106 Salpingoeca rosetta

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap