Conserved Protein Domain Family
F-box_FBXL6
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cd22119: F-box_FBXL6 
F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins
FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.
Links
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Statistics
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PSSM-Id: 438891
Aligned: 23 rows
Threshold Bit Score: 59.1886
Created: 12-Jan-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative Skp1
Feature 1:putative Skp1 binding site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #   #  ##  ##                   # ##        ### #            
Q8N531        112 GDRIPLEILVQIFGLLVaad-----------gpMPFLGRAAr-----VCRRWQEAASQ-PALWH 158  human
NP_001296447  145 GQSLPLEILVKIFQFAVfqd-----------gaVPLLCRVGr-----VCRLWNGAASS-PILWR 191  zebrafish
KYO46743       47 GERVPLEILERVFRVSVace-----------gaVPFLCRVAr-----VCRLWYRAAAS-PALWQ 93   American alligator
XP_007899405  139 GQQLPAEVLVHIFHYIVsse-----------gaVPFLCRVSr-----VCRLWYGAAAS-PSLWH 185  elephant shark
XP_002596393  224 GQLLPVEVIVNILQFAVadq-----------gaVPLLCRAAk-----VCHFWYEATKH-PSLWR 270  Florida lancelet
XP_013416120  116 GTVIPPEILLRIFHFAVsqn-----------rsLPFLCRAAr-----VCRLWRNTATH-PSLWA 162  Lingula anatina
PIO28664       79 GSIIPVEILHRVFRFLVdse-----------gaVPVLCRLSq-----VCRLWRQVASS-LDLWH 125  American bullfrog
PVD21530      144 CPHLPPELWLKVFQSVVrna-----------gpLPFLCRAAk-----VCRSWHQLCSH-PSLWY 190  Pomacea canaliculata
KAB5595890    257 VSRIPTEILARVFEFGVnangtrieigseafapLPETCRLFlgvvrrVCRMWKEVADStPSLWS 320  Ceratobasidium theobromae
TRY62661     1815 WSELPPKALRLLFRCGVane-----------gaIPFLVRVSr-----VCKSWNKEAMD-PTIWT 1861 Tigriopus californicus

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