Conserved Protein Domain Family
F-box_FBXO41
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cd22109: F-box_FBXO41 
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins
FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.
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Statistics
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PSSM-Id: 438881
Aligned: 20 rows
Threshold Bit Score: 56.9538
Created: 1-Feb-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative Skp1
Feature 1:putative Skp1 binding site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #       #  ##  ##   # ##   ### #                  
Q8TF61        547 SPEILKm---RAALFCIFTYLDTRTLLHAAEVCRDWRFVARHP----AVWTRVL 593  human
OWF51407     2287 RREAVRq--rRTSLYLVFRYLDTKSLGRVAGVCREWKKVSRQS----ALWKRVH 2334 Yesso scallop
EDO42697      607 SVDRLRarkrRVALGLVFRYLDPLELCRLATVCREWRSLSEHP----SLWQRVV 656  starlet sea anemone
XP_002599421  285 QAELVRr--rQDALSLAFSYLDTKSLCVCSMVCREWTLISRQP----ALWRQVH 332  Florida lancelet
XP_022091809  530 KQDPHW----QAVWLCVFTYLDTETLLTCAEVCRGWRTISKHP----SLWQIVR 575  crown-of-thorns starfish
XP_030842210  571 HFEPKKr---RAILFLVFSYLRTSTKLKCASVCREWRDVSHQP----ELWQYVH 617  purple sea urchin
Q9SV01         22 SIESLD----ADILCIIFSFLDLFDLVHCTVVCNSWNAVIKRL----KLLQASC 67   thale cress
Q9SMY8        192 VHIDLT----DDLLHMVFSFLNHVDLCRSAMVCRQWRVASAHE----DFWRVLN 237  thale cress
TMW62571       70 SCESLF----EGFFPIVTAFLDIVSLLSCEQVCRAWHEAVQDG----YVWEQFY 115  Pythium oligandrum
ETO30530        5 RQFSIP----EDIHLFVLTFLELKSLVHCSEVCHSWQKLVKSEkanvILWKRMY 54   Reticulomyxa filosa

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