Conserved Protein Domain Family
F-box_FBXO33
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cd22104: F-box_FBXO33 
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins
FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.
Links
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Statistics
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PSSM-Id: 438876
Aligned: 23 rows
Threshold Bit Score: 65.74
Created: 11-Jan-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative Skp1
Feature 1:putative Skp1 binding site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #    #  ##  ##   # ##   ### #                   
Q7Z6M2        68 AASLPS-ELIVHIFSFLpAPDRLRASASCSHWRECLFYp--aLWPQLRICL 115 human
XP_027232592   5 WNLLPS-VILIEILSYLpLSDKISACSTCKAWRSALFHp--sFWRKIELVF 52  Pacific white shrimp
RWS05479       7 WNNIPT-VVLFKIYSNLsRNERMQASSTCKAWRESLFHp--sIWPSKRIEC 54  Dinothrombium tinctorium
KPM06062      56 WKNLPL-VILYKIFSYLgPEDRLRSSTTCSSWRNVIYHs--tLWPKKHLKV 103 Sarcoptes scabiei
XP_017776891  55 WEMLPA-AVVDNVFKYLkFNDVKSASSACRNWRHGLYHp--rLWQHVRFEI 102 Nicrophorus vespilloides
PAA58337       5 WESAPI-TILENVFKYLgFRDRYHASQVCFQWYDAFYCp--sLWSYLTIDG 52  Macrostomum lignano
Q18223        82 ASRLPL-KVLNQIFQYLpLKDLRSAMLTCHSWNNALSMedsdIWQYLLGKK 131 Caenorhabditis elegans
NP_648285     10 WHRIPS-VALNHIFDYLnPQDRRSAAGVCFSWRHALFQk--rYFRNFRFQL 57  fruit fly
XP_001861605  70 WDNLPMeVVLIHVFTFIrPSDRNSAALTCRRWFEALRHp--qFLNATCFHF 118 southern house mosquito
TMW52104      16 YGNLPM-EIILHIFRFLnHSDLQAAGGTCSRWREALFVg--eFNRNIVVHF 63  grey fleshfly

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