Conserved Protein Domain Family
F-box_FBXO24
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cd22098: F-box_FBXO24 
F-box domain found in F-box only protein 24 (FBXO24) and similar proteins
FBXO24, also called FBX24, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It recognizes deacetylated nucleoside diphosphate kinase A (NDPK-A) to enhance its degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.
Links
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Statistics
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PSSM-Id: 438870
Aligned: 12 rows
Threshold Bit Score: 62.7246
Created: 11-Jan-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative Skp1
Feature 1:putative Skp1 binding site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #   #  ##  ##   # ##     ### #                 
O75426        38 SIQLFPPELVEHIISFLPVRDLVALG--QTCRYFHEVCDGE--GVWRRICR 84  human
GCF55640      32 SIQVFPPELLYYIISFLPVKDVVALG--QTCRYFYEVCDSE--GVWQRICR 78  Paroedura picta
XP_006011903  48 CIQDFPPELMDQIISYLPVKDIVGLG--QVCRYFRDVCNSG--RIWRRICK 94  coelacanth
NP_001121522  52 TFLGLPPEMLDRIVSFLPLRDMVALG--ETCRYLHQLCNSQ--SAWRRICG 98  tropical clawed frog
XP_029437705  30 SIQSFPPELLDHIISYLPVRDVVTLG--ESCRYFHEVCDSE--AIWRRICK 76  two-lined caecilian
XP_009474717 102 PEAEQPPDQLLHIISFLTLPDVLRLG--QTCRYFHEVCDGE--ATWHHLCT 148 crested ibis
TRY63487      20 SLIDLPPEILCHVVSFLPVVSVPALA--QSCRVGQSICDTE--TVWDALTR 66  Tigriopus californicus
KIL70506       4 LILELPDEIVDRIVEHLPVCDIPSLA--LTCHRLHNISISHyySLVSISCL 52  Amanita muscaria Koide BX008
EDV23834       8 NLISLPAEVICRIISHVPVECHPSVS--LTCRYMRECSHVD--RLWLQRCR 54  Trichoplax adhaerens
EKV42734       1 MLGDIPPEIVSEIVSHLPYKDIVALRqvFTCEDFCDATNAH--AVWLNLAK 49  Agaricus bisporus var. bisporus H97
RUS73836      40 HFLDLPVEMLMYIASFLPTSSIGSLA--QTCQHLLDVTNID--AIWQQLCY 86  eastern emerald elysia
KIK57623       5 KLVDLPEEVIIYLLSFLPVNEILSLR--QTCKFLNEITNLS--IVWISAWD 51  Gymnopus luxurians FD-317 M1

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