Conserved Protein Domain Family
F-box_FBXO13

cd22092: F-box_FBXO13

F-box domain found in F-box only protein 13 (FBXO13) and similar proteins

FBXO13, also called FBX13, F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

Links

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Source:	cd09917
Taxonomy:	Eumetazoa
PubMed:	6 links

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures
Superfamily:	cl45894

Statistics

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PSSM-Id:	438864
Aligned:	10 rows
Threshold Bit Score:	74.7636
Created:	11-Jan-2019
Updated:	17-Oct-2022

Structure

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Conserved Features/Sites?
PubMed References ?

putative Skp1

Feature 1:putative Skp1 binding site [polypeptide binding site]

Evidence:

Comment:based on the structure evidences that other F-box superfamily members interact with Skp1
Comment:F-box proteins participate in SCF (Skp1-Cul1-F-box protein) complexes that function as ubiquitin E3 ligases, where the role of the F-box protein is to recruit target substrates.
Citation:PMID 17389369
Citation:PMID 11961546
Citation:PMID 12820959
Citation:PMID 20581844
Citation:PMID 17410169
Citation:PMID 27479325

Scroll to Sequence Alignment Display

Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

Feature 1            #   #  ##  ##   # ##    ### #                
Q9UF56       320 DINQLPPSILLKIFSNLSLDERCLsASLVCKYWRDLCLDFQFWKQLDLS 368 human
B1H1X1       293 HINQLPSSLLLKIFSNLSLNERCIlASLVCKYWRDLCLDSQFWKQLDLS 341 African clawed frog
XP_001335097 220 HINQLPSSILLKVFSHLSVKERCLaASLVCKYWRDLCLDFQFWKQIDLS 268 zebrafish
OPJ86435      59 DINQLPPSILLKIFSNLSLNERCLsASLVCKYWRDLCLDFQFWKQLDLS 107 Patagioenas fasciata monilis
XP_007891328 208 NINQLPSSILLKVFSHLSLKERCLsASLVCKYWRDLGLDFQFWKQLDLS 256 elephant shark
XP_005995766 201 NINQLPSSILLKIFSNLSLKERCLsASLVCKYWRDLSLDFQFWKQLDLS 249 coelacanth
XP_002119406  63 NINQLPYSVLVKIFSYLSVEDRLLdLCFVCKHWHQVCHDQTFWKEIDFS 111 vase tunicate
XP_019622593 261 SINDLPQTVLLKIVSYLSMEERSRhVCRVCKLWNQMCLDSELWRKIDLR 309 Belcher's lancelet
XP_022787497  40 PQWLLPDNIWLRIFSYLSLQQRTQ-ASYVCQRWNNLCKDSTFWREVDFK 87  Stylophora pistillata
XP_031552868  46 GFDHLPDNIILQIVSYLNSQDCVK-ASMLCKKWYNVCQDRSLWNKMDFS 93  Australian red waratah sea anemone

Citing CDD

Jiyao W et al.(2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.

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