3L2O


Conserved Protein Domain Family
F-box_FBXO4
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cd22085: F-box_FBXO4 
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F-box domain found in F-box only protein 4 (FBXO4) and similar proteins
FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.
Links
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Statistics
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PSSM-Id: 438857
Aligned: 9 rows
Threshold Bit Score: 81.3026
Created: 11-Jan-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Skp1 binding
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:Skp1 binding site [polypeptide binding site]
Evidence:
  • Comment:F-box proteins participate in SCF (Skp1-Cul1-F-box protein) complexes that function as ubiquitin E3 ligases, where the role of the F-box protein is to recruit target substrates.
  • Structure:3L2O; Homo sapiens FBXO4 in complex with Skp1, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #### #  ##  ##  ## # # ######## ##   #            
3L2O_B         3 STLTRLPIDVQLYILSFLSPHDLCQLGSTNHYWNETVRDPILWRYFLLRD 52  human
Q9UKT5        57 STLTRLPIDVQLYILSFLSPHDLCQLGSTNHYWNETVRDPILWRYFLLRD 106 human
XP_006007172  50 IGLQNLPIDMQLYIMSFLLPRDLCQLACTSHYWNSAVRDTLLWRYFLLRD 99  coelacanth
NP_001121213  56 SLLCDLPVDMQLYIMTFLTPHDLCSLGMTNHYWDQMTRDRLLWRYFLLRD 105 African clawed frog
KTF94084      41 PSLDNLPVDMQFLIMTFLSPQDLCRLGGTSTYWRSMVRDPVLWKYFLLRD 90  common carp
TFK11669      58 CALQTLPIDVQLYIISFLSPQDLCHLGSTNQYWSLTVRDPLLWRYFLLRD 107 big-headed turtle
WP_010303024  49 DPLSSLPAELQYHILQFLSPEDLCRLSLVSHVWHILTKDENLWRRHSHVL 98  Candidatus Odyssella thessalonicensis
GAO47992     180 PLMNHLPTELTLQILSSLSPLDLFSLSLTSHAYHTLATHNILWEPLCRTL 229 Saitoella complicata NRRL Y-17804
XP_020378172  53 NTLHKLPAEVQMYIMGLLSPRDLCQLGCVSRYWNAMVHDPLLWRYFLLRD 102 whale shark

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