Conserved Protein Domain Family
F-box_FBXO3
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cd22084: F-box_FBXO3 
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins
FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.
Links
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Statistics
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PSSM-Id: 438856
Aligned: 19 rows
Threshold Bit Score: 83.848
Created: 11-Jan-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative Skp1
Feature 1:putative Skp1 binding site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #   #  ##  ##   # ##   ### #                  
Q9UK99        13 LESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCKKYW 61  human
ELU11977       6 LLRLPDDPLLHVLSFVNYRDLINCCFTCQRLRELTQQDALWRTQCKAVW 54  Capitella teleta
XP_013383632   7 LNNIPDDPLNHIFSYLDYKDLVSCCRACHRLHAVAENNVHWKRLCQFYW 55  Lingula anatina
XP_015760120   8 LSSLPVIPLFKIFSFLDKQDVAKCSQVCSRFNQVASTLPSWKKWCEDIW 56  Acropora digitifera
XP_001635571  14 LDNLPTIPLASVLSYLNARDLARCSRVCRRFDEICSSLPSWKAWCENGW 62  starlet sea anemone
XP_013791830   8 VINLPPELLLNIFAFLDYKDLICCSKLNKKFHDLSSHNCLWKPLCKKYW 56  Atlantic horseshoe crab
XP_023242744   2 LNDLPFEILLDIFTYLDYKDLICCGQLNRRLREASNHDSPWRLQCKKYW 50  bark scorpion
XP_014673711   8 LDELPSDVLIYILSHVSFRDIVSCCHQCQRLRSLCSDELLWRGQCKCVW 56  Priapulus caudatus
XP_029649057  12 IFHLPPETLVHIFSYFDFRDLIRCCKVCRRFYDIHFDDLLWKRFCYQNF 60  Octopus sinensis
KFM69163       7 LNDLPSELINQIFSHLDYNDLKNCKCLNKRFYALAKDENHWRELCKLYW 55  Stegodyphus mimosarum

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