3WSO,2E31


Conserved Protein Domain Family
F-box_FBA
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cd22083: F-box_FBA 
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F-box domain found in the F-box associated (FBA) family of F-box proteins
The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.
Links
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Statistics
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PSSM-Id: 438855
Aligned: 10 rows
Threshold Bit Score: 55.0883
Created: 26-Feb-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Skp1 binding
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:Skp1 binding site [polypeptide binding site]
Evidence:
  • Comment:F-box proteins participate in SCF (Skp1-Cul1-F-box protein) complexes that function as ubiquitin E3 ligases, where the role of the F-box protein is to recruit target substrates.
  • Structure:3WSO; Homo sapiens FBXO44 in complex with Skp1, contacts at 4A
  • Structure:2E31; Mus musculus FBXO2 in complex with Skp1, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  ##  #   #  # #  # #  ###### ##    
3WSO_A         6 INELPeNILLELFTHVPARQLLLnCRLVCSlWRDLID 42  human
2E31_A        51 LAELPePLLLRVLAELPATELVQaCRLVCLrWKELVD 87  house mouse
Q96EF6        18 LDALPpELLVQVLSHVPPRSLVTrCRPVCRaWRDIVD 54  human
XP_028648642  48 LSEVSdDILFLILIHVPFCELITnCRLVCKrWKDVVD 84  reedfish
GBM71402      34 NFSIPdDLLIDILSHVPASDLIKnCRLVCKdWKSIID 70  Araneus ventricosus
EGX45563      38 PLLIP-ELLEIILTSIPQLEVLTtCRSICTlWRDIID 73  Arthrobotrys oligospora ATCC 24927
KZS17636      20 NTFIArELVALILTQVDYQSLIAsCRLVCKqWNSIIT 56  Daphnia magna
XP_026442043   4 FKFILyEVISEILTPVPAESALD-CKLVCTsWRNIVS 39  opium poppy
RXM93414       5 FSEVSvFLLEEILVQVPATDLVHrCRLVSSlWRDVVD 41  sterlet
NP_001088554   4 INQLPeDALLYILTLVPATDLIR-YRHVCTvWRNLID 39  African clawed frog

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