Conserved Protein Domain Family
F-box_FBXO1
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cd22082: F-box_FBXO1 
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins
FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.
Links
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Statistics
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PSSM-Id: 438854
Aligned: 23 rows
Threshold Bit Score: 74.9741
Created: 12-Jan-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative Skp1
Feature 1:putative Skp1 binding site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #   #  ##  ##   # ##   ### #                    
P41002        31 TILSLPEDVLFHILKWLSVEDILAVRaVHSQLKDLVDNhaSVWACASFQELW 82  human
XP_006824002  19 NVWCLPEEVLVLLVKGLPAKDLLSMRaVHSKFRNIIDTnpSIWSTVNFRGEW 70  Saccoglossus kowalevskii
XP_013399273  37 TIWSLPEEILLLLLQGLHIKDLLNMAaVHSYFRDLIYShtSLWAGINFDETW 88  Lingula anatina
XP_002595380  32 DIWALPEELQLLMLRYLPAKDLANMRlVHSSFKQLVDNnpTLWVNTNFGGIW 83  Florida lancelet
PIK51629       9 EIEDLPDEMLLHILKFLHLQDLLNAVqVNARFKELIEGtkKLWSDVSLVGRW 60  Japanese sea cucumber
XP_022089434  18 TLSSLPHEVLVQLFKFLPLRDLINTRqVCSKFKWLIDStpHLWTTATLVDEW 69  crown-of-thorns starfish
XP_009065348  52 TLWHLPEEICLHLLKHLHIKDLLNMKlVHSYFNDLISNnnSLWSCVQFHNCW 103 owl limpet
XP_014681886  39 KIWSLPEELHLRLLEGLPLIDLITMRaVHPVFKDLIDSnpKLWSIANVNGHW 90  Priapulus caudatus
XP_030840623  47 MLTDLPDELLIYLLKFLPMCDLQNMYrISKQFKWLLDStpRIWANASVVGRW 98  purple sea urchin
XP_029634078  35 TIWNLPEEILILLLKELHIKELLNMRaVHPYFRNLIDNslSIWSVVNFQDSW 86  Octopus sinensis

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