4Y60


Conserved Protein Domain Family
HMG-box_SoxF_SOX18
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cd22048: HMG-box_SoxF_SOX18 
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high mobility group (HMG)-box found in sex determining region Y (SRY)-box 18 (SOX18) and similar proteins
SOX-18 is a transcription factor involved in the development of cardiovascular and lymphatic vessels during embryonic development. It binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site. SOX-18 belongs to the group F of SRY-related high-mobility group (HMG) box (Sox) transcription factors.
Links
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Statistics
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PSSM-Id: 438851
Aligned: 7 rows
Threshold Bit Score: 140.206
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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DNA binding
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:4Y60; Mus musculus SOX-18 binds DNA, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          # ## ## ##   #  #           ##  ##  #  ##                 #           ####    
4Y60_C         1 GLRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNTAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQ 80  house mouse
P35713        82 ESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQ 161 human
B3DLD3        65 DPRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGQSWKNLSSAEKRPFVEEAERLRVQHLQDHPNYKYRPRRKKQ 144 tropical clawed...
AWP10035      61 EQRIRRPMNAFMVWAKDERKRLAVQNPDLHNAVLSKMLGQSWKSLSAPDKRPFVEEAERLRVQHLQDHPNYKYRPRRKKT 140 turbot
XP_006010839 100 ESKIRRPMNAFMVWAKDERKKLAQQNPDLHNAVLSKMLGQSWKALSALEKRPFVEEAERLRVQHLQDHPNYKYRPRRKKQ 179 coelacanth
XP_007883198  57 ESRIRRPMNAFMVWAKDERKRLALQNPDLHNAVLSKMLGQAWKSLPTDEKRPFVEEAERLRVQHLHDHPNYKYRPRRKKQ 136 elephant shark
NP_989640     97 DSRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGQSWKALSASDKRPFVEEAERLRIQHLQDHPNYKYRPRRKKQ 176 chicken

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