Conserved Protein Domain Family
HMG-box_SoxF_SOX7
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cd22046: HMG-box_SoxF_SOX7 
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 7 (SOX7) and similar proteins
SOX-7 is an endothelial-associated transcription factor that acts as a tumor suppressor in a number of cancer types. It binds the DNA sequence 5'-AACAAT-3'. SOX-7 belongs to the group F of SRY-related high-mobility group (HMG) box (Sox) transcription factors.
Links
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Statistics
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PSSM-Id: 438849
Aligned: 6 rows
Threshold Bit Score: 184.892
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on the structure evidence that Mus musculus SOX-17 binds DNA
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    ## ## ##   #  #          ###  ##  #  #                             #
Q9BT81        34 RPPGDKGSESRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTLSQKRPYVDEAERLRLQHMQDYPNYK 113 human
O42342        31 RSPREKGSETRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALSPAQKRPYVEEAERLRVQHMQDYPNYK 110 African clawed ...
NP_001074219  32 RAPADKVSEPRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTPPQKRPYVEEAERLRVQHMQDYPNYK 111 zebrafish
XP_006003042  31 RSPGEKGSETRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTPSQKRPYVEEAERLRVQHMQDYPNYK 110 coelacanth
TFJ99947      29 RSPGEKGSEPRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKSLSPSQKRPYVEEAERLRVQHMQDYPNYK 108 big-headed turtle
AFK10672      30 ESPARNKTEPRIRRPMNAFMVWAKDERKKLAIQNPDLHNAELSKMLGRSWKALAPAQKRPFVEEAERLRVQHMQDHPNYK 109 elephant shark

Feature 1        # ###   
Q9BT81       114 YRPRRKKQ 121 human
O42342       111 YRPRRKKQ 118 African clawed frog
NP_001074219 112 YRPRRKKQ 119 zebrafish
XP_006003042 111 YRPRRKKQ 118 coelacanth
TFJ99947     109 YRPRRKKQ 116 big-headed turtle
AFK10672     110 YRPRRKKQ 117 elephant shark

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