3U2B


Conserved Protein Domain Family
HMG-box_SoxC_SOX4
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cd22036: HMG-box_SoxC_SOX4 
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high mobility group (HMG)-box found in sex determining region Y (SRY)-box 4 (SOX4) and similar proteins
SOX-4 is a transcriptional activator that promotes neuronal differentiation both in the adult and embryonic neural progenitors. It binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. SOX-4 is abnormally expressed in various cancers. SOX-4 belongs to group C SRY-related high-mobility group (HMG) box (Sox) transcription factors.
Links
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Statistics
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PSSM-Id: 438845
Aligned: 9 rows
Threshold Bit Score: 131.404
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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DNA binding
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:3U2B; Mus musculus SOX-4 binds DNA, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # ## ## ##   #  #   #      ###  ##  #  ##                 #           # ###   
3U2B_C         1 GHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIQEAERLRLKHMADYPDYKYRPRKKVK 79  house mouse
XP_006013083  56 GHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYKYRPRKKVK 134 coelacanth
NP_998287     62 GHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYKYRPRKKVK 140 zebrafish
XP_007901360  56 GHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDCDKIPFIREAERLRLKHMADYPDYKYRPRKKAK 134 elephant shark
Q06945        57 GHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYKYRPRKKVK 135 human
AAP79094      57 GHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYKYRPRKKVK 135 chicken
NP_001079998  58 GHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKQLKDSDKIPFIREAERLRLKHMADYPDYKYRPRKKVK 136 African clawed frog
OWK59182      57 GHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYKYRPRKKVK 135 Bengalese finch
KAA0710655    57 GHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYKYRPRKKVK 135 Triplophysa tibe...

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