Conserved Protein Domain Family
HMG-box_KMT2D
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cd22027: HMG-box_KMT2D 
high mobility group (HMG)-box found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
KMT2D, also called ALL1-related protein (ALR), is encoded by the gene that was named myeloid/lymphoid or mixed-lineage leukemia 4 (MLL4), a fourth human homolog of Drosophila trithorax, located on chromosome 12. KMT2D enzymatically generates trimethylated histone H3 Lys 4 (H3K4me3). It plays an essential role in differentiating the human pluripotent embryonal carcinoma cell line NTERA-2 clone D1 (NT2/D1) stem cells by activating differentiation-specific genes, such as HOXA1-3 and NESTIN. It is also a part of activating signal cointegrator-2 (ASC-2)-containing complex (ASCOM) that contains the transcriptional coactivator nuclear receptor coactivator 6 (NCOA6), KMT2C and KMT2D. The ASCOM complex is critical for nuclear receptor (NR) activation of bile acid transporter genes and is down regulated in cholestasis.
Links
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Statistics
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PSSM-Id: 438836
Aligned: 7 rows
Threshold Bit Score: 190.682
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                             # #####  ##      #         ##  #  ##      #   #  #   #  #   
O14686       1995 GLSYNQRSLQRWEKDEELGQLSTISPVLYANINFPNLKQDYPDWSSRCKQIMKLWRKVPAaDKAPYLQKAKDNRAAHRIN 2074 human
OWK50299     2162 GLSYNQRSLQRWEKDEELGELSTISPVLYANMNFPNLKQDYPDWSSRCKQIMKLWRKVPAtDKAPYLQKAKDNRAAHRIN 2241 Bengalese finch
XP_014348614 1449 GLSYNQRSLQRWEKDEELGELSTISPVLYSNINFPNLKQDYPDWSSRCKQIMKMWRKVAAaDKAPYLQKAKDNRAAQRIN 1528 coelacanth
PIO39592      107 GLSYNQRSLQRWEKDEELGEMSTISPVLYANKNFPNLKKDYPDWSSRCKQIMKLWRKVPAqDKAPYLQKAKDNRAAHRIN 186  American bull...
XP_007907786 1643 GLSYNQRSILRWEKDEALGELSTISPVLYANINFPNLKQDYPDWANRCKQITKIWRKVPAtDKAPYLQKAKDNRAAQRIN 1722 elephant shark
KPP74821     1374 GLSYNQRSLQRWEKDEELGELSTISPVLYANINFPNLKQDYPEWSNRCKQIMKIWRKVSAaDKVPYLQKAKDNRAAQRIN 1453 Asian bonytongue
OCT95633     1433 GLSYNQRSLQRWEKDEELGELSTISPVLYANKNFPNLRLEYPDWTSRCKQIMKLWRKVPAsDKAPYLQKAKDNRAAHRIS 1512 African clawe...

Feature 1             
O14686       2075 KVQK 2078 human
OWK50299     2242 KVQK 2245 Bengalese finch
XP_014348614 1529 KVQK 1532 coelacanth
PIO39592      187 KVQK 190  American bullfrog
XP_007907786 1723 KAQK 1726 elephant shark
KPP74821     1454 KAQK 1457 Asian bonytongue
OCT95633     1513 KVQR 1516 African clawed frog

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