5JGH


Conserved Protein Domain Family
HMG-box_ABF2_IXR1-like_rpt2
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cd22012: HMG-box_ABF2_IXR1-like_rpt2 
Click on image for an interactive view with Cn3D
second high mobility group (HMG)-box found in Saccharomyces cerevisiae mitochondrial ARS-binding factor 2 (ABF2), intrastrand cross-link recognition protein (Ixr1) and similar proteins
ABF2 is a close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria. It specifically binds to the autonomously replicating sequence 1 (ARS1). It might play a positive role in gene expression and replication. Ixr1, also called structure-specific recognition protein (SSRP), is a homolog of the yeast mitochondrial regulator ABF2. It binds to platinated DNA and confers sensitivity to the anticancer drug cisplatin. Both ABF2 and Ixr1 contain two HMG-box domains. This model corresponds to the second one.
Links
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Statistics
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PSSM-Id: 438828
Aligned: 20 rows
Threshold Bit Score: 64.6143
Created: 24-Jun-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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DNA binding
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:5JGH; Saccharomyces cerevisiae Abf2p binds DNA, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ##   ###   #              ##  ### ## ##          #  #   #     
5JGH_A        95 PPKKPAGPFIKYANEVRSQVFAQHPdksQLDLMKIIGDKWQSLDQsIKDKYIQEYKKAIQEYNA 158 Saccharomyces cerevisiae S288C
XP_001647361 125 PPKRPGGPFIQYANEVRSSVDEKYSelsLVERTKKIGEGWRSLSEyERQQYTDKYEALMNEWKL 188 Vanderwaltozyma polyspora DSM 7...
XP_003671555 126 PPKKPTPAYITFAQDIRESIVNEDPtltFNEVSKITSEKWQQLDQtEKDKYLNDYKENLKKWES 189 Naumovozyma dairenensis CBS 421
XP_022463923 139 PPKKPAAPFFLFTKDVRSSVVDAHPdatFGEISTLVSQKWNSMEEsKKEEYHDLYKKQLKEWED 202 Kazachstania naganishii CBS 8797
PFH47571     111 PPSSPGGPYLQFAKEYHAKYPIKSLp-eAAEAMKKCGAAWNALDKsEKEKYYEQYRKAFEEYAV 173 Amanita thiersii Skay4041
EPR78763      10 GPTKPLSGYFKFCAEQRKKLSDEIKnlsVGDQAKKFSVLWSEVDDsDKERLNKEYLEKMKIYNE 73  Spraguea lophii 42_110
XP_012278210  58 PPKKPANSYLLFIQDHKDKYYKSSEgmkYTDFVKKVAQEWAQIDEaEKKNMQKEYEKRMNDYIN 121 Orussus abietinus
KOC65926       7 KPKRPEASFFLYIKYVKPKLTVENPhikYSDVIKRASKEWAELDPvEKQRYQMQYSKNYEIYIQ 70  Habropoda laboriosa
TBU03535      11 APKRPGSAYLIYCTKQRELMASELEnvpVKDQLKRFGEMWASLDPkEKEIYNAEYEKRSKEFKE 74  Hamiltosporidium tvaerminnensis
TIA90942     108 APKRPASAYLLFQNDERSKKDPNQS---QTDFMSQVGKNWNSLKPeEKQKYQERYQNSIEIFER 168 Wallemia hederae

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