Conserved Protein Domain Family
HMG-box_UBF1_rpt2

?
cd21999: HMG-box_UBF1_rpt2 
second high mobility group (HMG)-box found in upstream-binding factor 1 (UBF1) and similar proteins
UBF1, also called UBTF, nucleolar transcription factor 1, or auto-antigen NOR-90, is a nucleolar transcription factor that recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. UBF1 contains six HMG-box domains. This model corresponds to the second one.
Statistics
?
PSSM-Id: 438815
Aligned: 28 rows
Threshold Bit Score: 68.8195
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
 
putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1         ## #####  ##      #               ##  #  ##      #   #  #   #  #              
P17480       196 PEKPKTPQQLWYTHEKKVYLKvrpd----attKEVKDSLGKQWSQLSDKKRLKWIHKALEQRKEYEEIMRDYIQKHPEL 270  human
AAH55140     198 PEKPKTPQQLWYNHEKKTYMKihpe----vsqKELKEALRRQWSQLSDKKRLKWISKALELQKHYEDTMRAYIEAHPDA 272  zebrafish
XP_007908939 197 PEKPKTPQQLWYNHEKKAFLKlhpe----vslKELKDALRKQWSQLSDKKRLKWISKALELQKDYEATLKVYIEAHPDS 271  elephant shark
XP_015792052 246 PVRPKTPFQIFCRKKTAEKIDskevedgefskKDNLEQMRKAWHDLSDKKRLKWIKKSLADEKRYIEELSEFKKANPDY 324  two-spotted spi...
RWS29705     213 PAKAKTPFDFFKLKKLKNAEEgt--------sKQLYIQLRKEWQELSSKKKCKFIEKSLKDERRYKAECEEYKKDHPTF 283  Leptotrombidium...
ROT76263     475 VSAPRLPFEIYYSIESDKIGSk---------nKQLKAELRTKYNALKKKTKLKYIEESFKEFHKYKQEVAEYLKINPSY 544  Pacific white s...
XP_019628383 326 PTKPKTPVQMFIQEKVDDYMKahpn----gnkREATDALRKQWNALTDGKRIKWINKALGVQKKYTAEMEQYMKDHPDF 400  Belcher's lancelet
XP_022091128 213 PPKLLNPYQLWANKRFEALQRedhe----vtrGQLDAQLREEWKSMPDKKRVKWINKALEEQIKYGKDIEEYLEQNPNF 287  crown-of-thorns...
PIK39428     227 SPICPTPYRWWLAKQLMDRPEvp--------rSEVESELRAKWKALSDKRRLKWIHMSLQKKDEYEQAIQEYSKTHPNF 297  Japanese sea cu...
XP_002738418 254 VKKSMTPYQIFQNKRVESAINsnpk----mskKEIEDLLKGQWKSMTDKKKMVFIRGAIEEFKQYEKAVVEYQRTHPDY 328  Saccoglossus ko...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap