2CTO


Conserved Protein Domain Family
HMG-box_MAEL
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cd21992: HMG-box_MAEL 
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high mobility group (HMG)-box found in protein maelstrom (MAEL) and similar proteins
MAEL is an RNA-binding protein that has evolved from an ancient nuclease active in protists. It plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.
Links
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Statistics
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PSSM-Id: 438808
Aligned: 37 rows
Threshold Bit Score: 69.9561
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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putative DNA
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ## #####  ##      #               ##  #  ##      #   #  #   #  #
2CTO_A        12 KASRNAYYFFVQEKIPELRRRGlpva---rvaDAIPYCSSDWALLReeEKEKYAEMAREWRAAQ 72  human
XP_029835521   3 PKKKGPFFFLMREIQNTLKQENkpc----smeDARVEASLVWENMTadERAVYENMARDYRERG 62  black-legged tick
XP_022912783   5 KAPKNAFYFFFTELKAKQKTPCsn-------eKAVELASPLWNQMSpeERKPYEEKAKITKKNL 61  Onthophagus taurus
XP_019878625   6 NKKKNAFFYFMQEIKQKSGFNNl---------EAQEVAGEKWTRMTrdERRPYEIMASERRNNP 60  small hive beetle
ERL85441     217 SSKPNAYIVFAQDLMNRQGGRKyns-----lkEACDVAGPIWARMSreEKEPYEVRANIMRGDT 275 mountain pine beetle
XP_025425751   5 KKTYNAFSVFMMETQQRLAKTGkkm----smaDMPNYCKKEWEEMSddMKDKYKTMSKNMKNGS 64  yellow sugarcane aphid
KMQ94720       4 VKGRNAFFFFMREWRKRAEAQGrtfpnglkdvQADPDCNEEWQSLSkqEKGPYEAMAKQDKVDA 67  Lasius niger
XP_014230690   4 NNKKNAFFYFVLEMLKKSGSKMdik-----daCKDPEISDKWKHMSehEKAKYKAMEKTAKPNQ 62  Trichogramma pretiosum
XP_002427229   6 KSPKNAFSFFLDDYVQNQRDKGnhi----thkQGAEECASLWKNLSleEKERYKNLASEYKINK 65  human body louse
XP_026806579   2 ATKKNAFYIFLTDYRNEEINKGnkps---sfqQLSNKLAPIWNSMTdeEKNKYKVLARKNNSNQ 62  corn leaf aphid

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